Generation of blood group specificity: New insights from structural studies on the complexes of A- and B-reactive saccharides with basic winged bean agglutinin

2007 ◽  
Vol 68 (3) ◽  
pp. 762-769 ◽  
Author(s):  
Kiran A. Kulkarni ◽  
Samiksha Katiyar ◽  
Avadhesha Surolia ◽  
Mamannamana Vijayan ◽  
Kaza Suguna
Keyword(s):  
Blood Group ◽  
Winged Bean ◽  
Structural Studies ◽  
Group Specificity

An IgA High-Titer Cold Agglutinin with an Unusual Blood Group Specificity within the Pr Complex

Vox Sanguinis ◽  
1973 ◽  
Vol 25 (1) ◽  
pp. 32-38 ◽  
Author(s):  
G. Garratty ◽  
L.D. Petz ◽  
I. Brodsky ◽  
H.H. Fudenberg
Keyword(s):  
Blood Group ◽  
High Titer ◽  
Cold Agglutinin ◽  
Group Specificity

Immunosorbent method for the detection of A,B,O blood group specificity on CEA preparations

1978 ◽  
Vol 85 (4) ◽  
pp. 1453-1459 ◽  
Author(s):  
Richard Magous ◽  
Christian Lecou ◽  
Jean-Pierre Bali
Keyword(s):  
Blood Group ◽  
Group Specificity

A New Source of Antibody-Like Substances Having Anti-Blood Group Specificity

Vox Sanguinis ◽  
1968 ◽  
Vol 14 (5) ◽  
pp. 321-333
Author(s):  
O. Prokop ◽  
G. Uhlenbruck ◽  
W. Köhler
Keyword(s):  
Blood Group ◽  
Group Specificity

scholarly journals Studies on the Specificity of Autoantibodies in Acquired Hemolytic Anemia

Blood ◽  
1956 ◽  
Vol 11 (8) ◽  
pp. 700-707 ◽  
Author(s):  
LEONARD V. CROWLEY ◽  
BERTHA A. BOURONCLE
Keyword(s):  
Blood Group ◽  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Significant Proportion ◽  
Group Specificity ◽  
Practical Management ◽  
Survival Studies

Abstract A significant proportion of patients with autoimmune hemolytic anemia form autoantibodies of blood group specificity, rather than nonspecific autoantibodies. Ashby survival studies suggest that in such cases properly selected blood, lacking the antigens against which autoantibody has been formed, can be transfused successfully. These concepts are important not only for a better understanding of the nature of autoantibodies, but also can be applied to the practical management of patients with autoimmune hemolytic anemia.

Structural studies of the M blood group determinant

1983 ◽  
Vol 5 (5) ◽  
pp. 314-317 ◽  
Author(s):  
Ron L. Batstone-Cunningham ◽  
Robert E. Hardy ◽  
Kilian Dill
Keyword(s):  
Blood Group ◽  
Structural Studies

Prognostic value of the combination of blood group specificity and interleukin 28B gene polymorphism for estimation of efficiency of therapy with the use of pegylated interferon a-2 and ribavarin in patients with chronic genotype 1 hepatitis C

2016 ◽  
Vol 94 (3) ◽  
pp. 224-230
Author(s):  
P. P. Ogurtsov ◽  
Elena I. Kukhareva
Keyword(s):  
Hepatitis C ◽  
Gene Polymorphism ◽  
Blood Group ◽  
Hepatic Fibrosis ◽  
Pegylated Interferon ◽  
Interleukin 28B ◽  
Blood Group A ◽  
Group Specificity ◽  
Group A ◽  
Group B

Aim. To estimate the prognostic value of the combination of blood group specificity and interleukin 28B gene polymorphism for the achievement of sustained virologic response (SVR) to antiviral therapy (AVT) with the use ofpegylated interferon a-2 and ribavarin in patients with chronic genotype 1 hepatitis C (CHC-1). The secondary aim was to evaluate the influence of these genetic factors on the progress of hepatic fibrosis in case offailure of the above treatment. Materials and methods. A total of 146patients with CHC-1 were examined. We studied the RNA genotype of hepatitis C virus, blood group specificity, IL-28B gene polymorphism, and severity of hepatic fibrosis (puncture biopsies). Dynamics of hepatic fibrosis was followed up in 40 patients who failed to develop the virologic response. 20 control patients did not receive AVT. The multifactor significance criterion was used to identify the initial factor that produced the highest effect on SVR. Results. SVR was observed in 56.8% of the patients. Its efficiency was most significantly influenced by the combination of blood group specificity and interleukin 28B gene polymorphism (p=0.000024). Combination of blood group (0)1 with C/C or T/TIL-28B genotypes, A(II) with C/T or T/T, and B(III) with T/G was associated with SVR in 100, 88.2, and 94.4% cases respectively. It was absent in patients with blood group A(II) in combination with double-nucleotide substitution in rs8099917 of the IL-28B gene (TG and GG genotypes); these patients suffered progressive fibrosis. SVR occurred in 83.8% of the patients with blood group B(III). Conclusion. The knowledge of blood group in patients with CHC-1 and IL-28B gene polymorphism treated with the use of pegylated interferon a-2 and ribavarin allows to predict SVR with a probability of 100% in case of blood group 0(1) and C/C or T/T genotypes, 88.2% in case of blood group A(II) and single-nucleotide C>T substitution in rs8099917 locus of the IL-28B gene, 94.4% in case of blood group B(II) and single-nucleotide T>G substitution in the rs8099917 locus, 83.8% in case of blood group B(III). Treatment ofpatients with these genetic traits with antiviral drugs of direct action has no appreciable advances over treatment with AVT in combination with pegylated interferon a-2 and ribavarin (SVR above or around 85%). Patients with blood group A(II) and single- or double-nucleotide substitution in rs8099917 (TG or GG genotypes) have minimal chances to produce SVR to the above treatment. Simultaneous progression of hepatic fibrosis suggest that such therapy is undesirable in these cases. They should be regarded as main candidates for interferon-free therapy. Combination of blood group specificity and interleukin 28B gene polymorphism is a simple and reliable predictor of SVR and dynamics offibrosis in patients with CHC-1 receiving AVT with pegylated interferon a-2 and ribavirin; also, it may be an instrument of selection of patients for interferon-free therapy.

scholarly journals Effect of sialidase on blood group specificity of hog submaxillary glycoproteins

FEBS Letters ◽  
1970 ◽  
Vol 8 (6) ◽  
pp. 353-358 ◽  
Author(s):  
David Aminoff ◽  
Marianne P. Morrow
Keyword(s):  
Blood Group ◽  
Group Specificity

scholarly journals 500 MHz 1 H n.m.r. of oligosaccharides of N-acetyl-lactosamine-type released from human erythrocyte glycopeptides by endo-β-galactosidase

1988 ◽  
Vol 250 (1) ◽  
pp. 9-13 ◽  
Author(s):  
E F Hounsell ◽  
J Feeney ◽  
P Scudder
Keyword(s):  
Blood Group ◽  
Human Erythrocyte ◽  
Bacteroides Fragilis ◽  
Structural Studies ◽  
Beta Galactosidase

500 MHz 1H n.m.r. spectroscopy has been used in structural studies of three linear and five branched oligosaccharides of N-acetyl-lactosamine-type that were released from desialylated blood group O erythrocyte glycopeptides by treatment with the endo-beta-galactosidase of Bacteroides fragilis followed by reduction. The following oligosaccharide alditols were characterized: (formula; see book)

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