2-5A induces a conformational change in the ankyrin-repeat domain of RNase L

2005 ◽  
Vol 60 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Masayuki Nakanishi ◽  
Yoshikuni Goto ◽  
Yukio Kitade
Keyword(s):  
Conformational Change ◽  
Ankyrin Repeat ◽  
Rnase L ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain

Crystallization of the N-Terminal Ankyrin Repeat Domain of the 2-5ADependent Endoribonuclease, RNase L

2005 ◽  
Vol 12 (4) ◽  
pp. 387-389 ◽  
Author(s):  
Nobutada Tanaka ◽  
Masayuki Nakanishi ◽  
Yoshio Kusakabe ◽  
Yoshikuni Goto ◽  
Yukio Kitade ◽  
...  
Keyword(s):  
Ankyrin Repeat ◽  
Rnase L ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain

scholarly journals Crystal structure of the N-terminal ankyrin repeat domain of human RNase L

2005 ◽  
Vol 61 (a1) ◽  
pp. c247-c248
Author(s):  
N. Tanaka ◽  
M. Nakanishi ◽  
Y. Kusakabe ◽  
Y. Goto ◽  
Y. Kitade ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Ankyrin Repeat ◽  
Rnase L ◽  
Human Rnase ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain

Determination of Ankyrin Repeats Domain (ANK) a of RNASE L Gene in Hepatitis C Patients and its effects on Viral Load

2020 ◽  
Author(s):  
Anum Liaquat Ali
Keyword(s):  
Viral Load ◽  
Hepatitis C ◽  
Pcr Amplification ◽  
Ankyrin Repeat ◽  
Hcv Infection ◽  
Rnase L ◽  
Ankyrin Repeats ◽  
Genotype 3 ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain

Background: Hepatitis C virus (HCV) is one of the major global causes of death. Different types of gene are involved as Ankyrin repeat domains of RNASE L gene. It performs a significant role in antiviral response, regulated by interferon, and involved in cleavage of RNA. Therefore, aim of this study was to identify Ankyrin repeat domain expression in Hepatitis C positive patients and correlate it with viral load of Hepatitis C. Methods: In this study, a total of 80 HCV positive patient’s whole blood samples were investigated. RNA was extracted from plasma followed by Real Time PCR for quantization of HCV viral load and genotypic analyses. DNA was also extracted from these samples followed by PCR amplification of Ankyrin repeat domain of RNASE L gene. Data was analyzed using SPSS Results: All of the patients (n=80) included in study had HCV infection. Mean age of patients was 50.86 ±14.84 years. Among them, 48(63.8%) were males and 32 (36.1%) were females. Majority of patients were males and belonged to age group 58-73 years age. All HCV infected individuals 36 (45%) had HCV genotype 3 and had viral loads mean range 837404.21 ±1302. Therefore, Ankyrin repeats domain of RNASE L gene expression was high in HCV patients sample with viral load of 17.00±15.1. Conclusion: Ankyrin repeat domain expression was observed in Hepatitis C patients and its significant correlation with viral load of Hepatitis C. Ankyrin repeat domain of RNASE L gene in conjunction with therapeutic intervention are required for establishing better strategies for controlling HCV infection.

scholarly journals Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor

2007 ◽  
Vol 282 (33) ◽  
pp. 24027-24038 ◽  
Author(s):  
Mathew L. Coleman ◽  
Michael A. McDonough ◽  
Kirsty S. Hewitson ◽  
Charlotte Coles ◽  
Jasmin Mecinović ◽  
...  
Keyword(s):  
Hypoxia Inducible Factor ◽  
Ankyrin Repeat ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain

FIH-Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain-Containing Proteins

2009 ◽  
Vol 1177 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Matthew E. Cockman ◽  
James D. Webb ◽  
Peter J. Ratcliffe
Keyword(s):  
Ankyrin Repeat ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain

scholarly journals Clinical significance of Ankyrin repeat domain 12 expression in colorectal cancer

2013 ◽  
Vol 32 (1) ◽  
pp. 35 ◽  
Author(s):  
Rui Bai ◽  
Dan Li ◽  
Zhong Shi ◽  
Xuefeng Fang ◽  
Weiting Ge ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance ◽  
Ankyrin Repeat ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain

scholarly journals Ankyrin Repeat Domain 1 Overexpression is Associated with Common Resistance to Afatinib and Osimertinib in EGFR-mutant Lung Cancer

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Akiko Takahashi ◽  
Masahiro Seike ◽  
Mika Chiba ◽  
Satoshi Takahashi ◽  
Shinji Nakamichi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Ankyrin Repeat ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain ◽  
Egfr Mutant

scholarly journals Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin

Cell Calcium ◽  
2020 ◽  
Vol 90 ◽  
pp. 102228 ◽  
Author(s):  
Lavanya Moparthi ◽  
Satish Babu Moparthi ◽  
Jérôme Wenger ◽  
Peter M. Zygmunt
Keyword(s):  
Ankyrin Repeat ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain
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