Signal transduction in the photoactive yellow protein. II. Proton transfer initiates conformational changes

2002 ◽  
Vol 48 (2) ◽  
pp. 212-219 ◽  
Author(s):  
Gerrit Groenhof ◽  
Marc F. Lensink ◽  
Herman J. C. Berendsen ◽  
Alan E. Mark
Keyword(s):  
Signal Transduction ◽  
Proton Transfer ◽  
Conformational Changes ◽  
Photoactive Yellow Protein

scholarly journals Subpicosecond Excited-State Proton Transfer Preceding Isomerization During the Photorecovery of Photoactive Yellow Protein

2010 ◽  
Vol 1 (19) ◽  
pp. 2793-2799 ◽  
Author(s):  
Elizabeth C. Carroll ◽  
Sang-Hun Song ◽  
Masato Kumauchi ◽  
Ivo H. M. van Stokkum ◽  
Askat Jailaubekov ◽  
...  
Keyword(s):  
Excited State ◽  
Proton Transfer ◽  
Photoactive Yellow Protein ◽  
Excited State Proton Transfer

scholarly journals Oxidation Impacts the Intracellular Signaling Machinery in Hematological Disorders

Antioxidants ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 353
Author(s):  
Elena Tibaldi ◽  
Enrica Federti ◽  
Alessandro Matte ◽  
Iana Iatcenko ◽  
Anand B. Wilson ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Conformational Changes ◽  
Intracellular Signaling ◽  
Signal Transduction Pathways ◽  
Functional Connection ◽  
Intracellular Signaling Pathway ◽  
Hematological Disorders ◽  
Dynamic Coordination ◽  
Transduction Mechanisms

The dynamic coordination between kinases and phosphatases is crucial for cell homeostasis, in response to different stresses. The functional connection between oxidation and the intracellular signaling machinery still remains to be investigated. In the last decade, several studies have highlighted the role of reactive oxygen species (ROS) as modulators directly targeting kinases, phosphatases, and downstream modulators, or indirectly acting on cysteine residues on kinases/phosphatases resulting in protein conformational changes with modulation of intracellular signaling pathway(s). Translational studies have revealed the important link between oxidation and signal transduction pathways in hematological disorders. The intricate nature of intracellular signal transduction mechanisms, based on the generation of complex networks of different types of signaling proteins, revealed the novel and important role of phosphatases together with kinases in disease mechanisms. Thus, therapeutic approaches to abnormal signal transduction pathways should consider either inhibition of overactivated/accumulated kinases or homeostatic signaling resetting through the activation of phosphatases. This review discusses the progress in the knowledge of the interplay between oxidation and cell signaling, involving phosphatase/kinase systems in models of globally distributed hematological disorders.

scholarly journals Exploring Electron/Proton Transfer and Conformational Changes in the Nitrogenase MoFe Protein and FeMo-cofactor Through Cryoreduction/EPR Measurements

2016 ◽  
Vol 56 (9-10) ◽  
pp. 841-851 ◽  
Author(s):  
Roman Davydov ◽  
Nimesh Khadka ◽  
Zhi-Yong Yang ◽  
Andrew J. Fielding ◽  
Dmitriy Lukoyanov ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Conformational Changes ◽  
Mofe Protein ◽  
Femo Cofactor ◽  
Epr Measurements ◽  
Electron Proton Transfer

Proton Transfer-Induced Conformational Changes and Melting In Designed Peptides in the Gas Phase

2006 ◽  
Vol 128 (22) ◽  
pp. 7193-7197 ◽  
Author(s):  
Motoya Kohtani ◽  
Thaddeus C. Jones ◽  
Rajagopalan Sudha ◽  
Martin F. Jarrold
Keyword(s):  
Proton Transfer ◽  
Gas Phase ◽  
Conformational Changes
Sign in / Sign up

Export Citation Format

Share Document