NK cell activity in treated prostate cancer patients as a probe for circulating tumor cells: Hormone regulatory effects in vivo

The Prostate ◽  
1992 ◽  
Vol 21 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Maja KašCtelan ◽  
Marko Tarle ◽  
Ivo Kraljić
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Regulatory Effects

1046 A new medical device for in vivo isolation of circulating tumor cells in prostate cancer patients

2013 ◽  
Vol 12 (1) ◽  
pp. e1046-e1047
Author(s):  
G. Theil ◽  
M.R. Hoda ◽  
K. Fischer ◽  
K. Haubold ◽  
T. Krahn ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Medical Device ◽  
Circulating Tumor Cells

Clinical validation of a medical device for in vivo isolation of circulating tumor cells in prostate cancer patients: One-year follow-up.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e16027-e16027 ◽  
Author(s):  
Gerit Theil ◽  
Kersten Fischer ◽  
Thomas Krahn ◽  
Andre Schumann ◽  
Kathrin Haubold ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Medical Device ◽  
Circulating Tumor Cells ◽  
Clinical Validation ◽  
One Year

Analysis of the Effect of Psychological Nursing Intervention on Perioperative Mood and NK Cell Activity in Breast Cancer Patients

2021 ◽  
Vol 7 (5) ◽  
pp. 3301-3314
Author(s):  
Jihong Yuan ◽  
Linghong Yuan ◽  
Yi Hu ◽  
Jingjing Gong ◽  
Yang Tong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Nk Cell ◽  
Psychological Intervention ◽  
Cell Activity ◽  
Nursing Intervention ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Nk Cell Activity ◽  
Intervention Measures

Breast cancer (Breast Cancer, BC) is one of the most common malignant tumors in women in the world. It is the first malignant tumor that causes the death of women in developing countries. It seriously threatens the lives and health of women and causes damage to the family, economy and society. Through psychological nursing intervention, it has a positive effect on the perioperative mood and NK cell activity of breast cancer patients. The purpose of this article is to explore the effects of psychological intervention on the perioperative mood and NK cell activity of breast cancer patients. This article is based on the concept and theory of psychological nursing intervention for female breast cancer patients, and establishes personalized intervention measures in conjunction with clinical practice to intervene the emotions of breast cancer patients during the perioperative period. This article analyzes the nature, intensity, and causes of negative psychology of the subject through in-depth understanding of the subject’s psychological emotions, coping ability, personality characteristics, past emotional experience, and social support, and discovers the different emotional characteristics of the patient, and formulates the personality psychological intervention measures to stimulate positive and optimistic attitudes and ease the degree of negative psychology. This article analyzes the psychological characteristics of several breast cancer patients. Take corresponding psychological intervention measures. Cope with a series of bad psychology caused by image damage caused by total mastectomy. The results and data in this article show that the incidence of anxiety and depression in the control group is higher than that of the psychological intervention group at 7 days after the operation, with P values of 0.0059 and 0. 0215.Psychological intervention reduces the incidence of negative emotions and reduces the negativeness of patients. The intensity of emotion has played a good clinical effect.

scholarly journals Circulating Tumor Cells as a Marker of Disseminated Disease in Patients with Newly Diagnosed High-Risk Prostate Cancer

Cancers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 160 ◽  
Author(s):  
Wojciech A. Cieślikowski ◽  
Joanna Budna-Tukan ◽  
Monika Świerczewska ◽  
Agnieszka Ida ◽  
Michał Hrab ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Metastatic Disease ◽  
Newly Diagnosed ◽  
High Risk Prostate Cancer ◽  
Intergroup Comparison ◽  
Risk Prostate Cancer

The aim of this study was to investigate whether the enumeration of circulating tumor cells (CTCs) in blood can differentiate between true localized and metastatic prostate cancer. A cross-sectional study of 104 prostate cancer patients with newly diagnosed high-risk prostate cancer was conducted. In total, 19 patients presented metastatic disease and 85 were diagnosed with localized disease. Analyses included intergroup comparison of CTC counts, determined using the CellSearch® system, EPISPOT assay and GILUPI CellCollector®, and ROC analysis verifying the accuracy of CTC count as a maker of disseminated prostate cancer. The vast majority (94.7%) of patients with advanced-stage cancer tested positively for CTCs in at least one of the assays. However, significantly higher CTC counts were determined with the CellSearch® system compared to EPISPOT assay and GILUPI CellCollector®. Identification of ≥4 CTCs with the CellSearch® system was the most accurate predictor of metastatic disease (sensitivity 0.500; specificity 0.900; AUC (95% CI) 0.760 (0.613–0.908). Furthermore, we tried to create a model to enhance the specificity and sensitivity of metastatic prediction with CTC counts by incorporating patient’s clinical data, including PSA serum levels, Gleason score and clinical stage. The composite biomarker panel achieved the following performance: sensitivity, 0.611; specificity, 0.971; AUC (95% CI), 0.901 (0.810–0.993). Thus, although the sensitivity of CTC detection needs to be further increased, our findings suggest that high CTC counts might contribute to the identification of high-risk prostate cancer patients with occult metastases at the time of diagnosis.

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