The use of steroid-containing silastic implants in male nude mice: Plasma hormone levels and the effect of implantation on the weights of the ventral prostate and seminal vesicles

The Prostate ◽  
1984 ◽  
Vol 5 (6) ◽  
pp. 639-647 ◽  
Author(s):  
G. J. Van Steenbrugge ◽  
M. Groen ◽  
F. H. De Jong ◽  
F. H. Schroeder
Keyword(s):  
Nude Mice ◽  
Seminal Vesicles ◽  
Ventral Prostate ◽  
Hormone Levels ◽  
Plasma Hormone

METABOLISM AND MODE OF ACTION OF ANDROGENS IN TARGET TISSUES OF MALE RATS

1972 ◽  
Vol 69 (1) ◽  
pp. 165-173 ◽  
Author(s):  
H. Schmidt ◽  
I. Noack ◽  
K. D. Voigt
Keyword(s):  
Cell Proliferation ◽  
Cell Metabolism ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Nucleic Acid Content ◽  
The Difference ◽  
Independent Effects ◽  
Sites Of Action ◽  
Peripheral Metabolism

ABSTRACT The effect of testosterone and 5α-dihydrotestosterone on protein and nucleic acid content as well as on the activities of some enzymes has been studied in the ventral prostate and the seminal vesicles of immature castrated rats. Both androgens were given intraperitoneally in doses of 1 mg daily for one or three days the rats were sacrificed one day after the last injection. In the prostate it was found that 5α-dihydrotestosterone had a greater effect on DNA increase, i. e. cell proliferation than testosterone, whereas cell metabolism was stimulated by the two androgens to nearly the same extent. In the seminal vesicles a single dose led to the same results as had been obtained in the prostate, i. e. a greater cell proliferative action of 5α-dihydrotestosterone and an equal stimulation of cell metabolism by testosterone and 5α-dihydrotestosterone was also observed. When three doses of the two androgens were given, cell proliferation as well as cell metabolism in the seminal vesicles were significantly more increased after 5α-dihydrotestosterone than after testosterone. The difference of action after systemic administration of the two androgens is explained by their different accumulation and by their different peripheral metabolism in the target tissues. From the partly independent effects of various androgens on cell proliferation and cell metabolism the conclusion may be drawn that there exist at least two intracellular sites of action.

Seminal Plasma Transferrin Concentration: Relationship with Seminal Parameters and Plasma Hormone Levels

1992 ◽  
Vol 49 (3) ◽  
pp. 158-162 ◽  
Author(s):  
H. Fuse ◽  
S. Satomi ◽  
M. Okumura ◽  
T. Katayama
Keyword(s):  
Seminal Plasma ◽  
Hormone Levels ◽  
Seminal Parameters ◽  
Plasma Hormone

24-Hour Mean Plasma Hormone Levels in Men with Coronary Heart Disease.

1981 ◽  
Author(s):  
Barnett Zumoff ◽  
David K. Fukushima ◽  
Robert S. Rosenfeld ◽  
Raymond G. Tropler ◽  
James Hickman
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Hormone Levels ◽  
Plasma Hormone

Lipolytic responsiveness to epinephrine in nondiabetic and diabetic humans

1997 ◽  
Vol 272 (6) ◽  
pp. E1130-E1135 ◽  
Author(s):  
G. D. Divertie ◽  
M. D. Jensen ◽  
P. E. Cryer ◽  
J. M. Miles
Keyword(s):  
Adipose Tissue ◽  
Insulin Dependent Diabetes ◽  
Response Curves ◽  
Epinephrine Infusion ◽  
Hormone Levels ◽  
Control Subjects ◽  
Insulin Dependent ◽  
Adipose Tissue Lipolysis ◽  
Plasma Hormone ◽  
Beta Hydroxybutyrate

To determine whether the sensitivity of adipose tissue lipolysis to catecholamines is increased in poorly controlled insulin-dependent diabetes, the lipolytic response to epinephrine was measured in seven nondiabetic volunteers and seven poorly controlled diabetic subjects with use of [1-(14)C]palmitate as a tracer. Subjects received sequential 1-h infusions of epinephrine, which produced epinephrine concentrations of approximately 1,000, approximately 1,750, approximately 3,500, and approximately 6,000 pmol/l. A pancreatic clamp was used to maintain constant plasma hormone levels. Concentration-response curves were constructed for each subject from the integrated lipolytic response during each epinephrine infusion. There was no difference in maximal lipolytic response (117 +/- 19 vs. 152 +/- 11 mumol.kg-1.h-1) or in maximally effective (3,171 +/- 267 vs. 3,357 +/- 349 pmol/l) or half-maximally effective (1,081 +/- 109 vs. 1,015 +/- 120 pmol/l) epinephrine concentrations between nondiabetic and diabetic subjects, respectively (all P = NS). In control subjects, maximum beta-hydroxybutyrate concentrations were achieved at lower epinephrine concentrations than those required for a maximum lipolytic effect. Thus, under pancreatic clamp conditions, the lipolytic response to epinephrine in nondiabetic and diabetic subjects was similar.

Influence of thymectomy on growth of secondary reproductive structures in rats

1964 ◽  
Vol 206 (1) ◽  
pp. 193-197 ◽  
Author(s):  
Constance R. Martin
Keyword(s):  
Sexual Development ◽  
Seminal Vesicles ◽  
Thymus Gland ◽  
Ventral Prostate ◽  
Sham Operation ◽  
Rapid Phase ◽  
Reproductive Structures ◽  
Response To Stress ◽  
Long Evans

Ventral prostate glands and seminal vesicles of Long-Evans rats, thymectomized at 6–6 1/2 weeks of age and autopsied 3 weeks later, were significantly heavier than those of sham-operated rats. Values for thymectomized rats were as great as or greater than those for unoperated controls. The influence of thymectomy and sham operation was less pronounced when surgery was performed on rats which had not yet entered or had completed the most rapid phase of sexual development. A possible role of the thymus gland in the response to stress is discussed.

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