scholarly journals IL‐8 protects prostate cancer cells from GSK‐3β‐induced oxidative stress by activating the mTOR signaling pathway

The Prostate ◽  
2021 ◽  
Author(s):  
Yi Sun ◽  
Jian‐Zhong Ai ◽  
Xi Jin ◽  
Liang‐Ren Liu ◽  
Tian‐Hai Lin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Prostate Cancer Cells ◽  
Gsk 3Β

IL‐8 protects prostate cancer cells from GSK‐3β‐induced oxidative stress by activating the mTOR signaling pathway

The Prostate ◽  
2019 ◽  
Vol 79 (10) ◽  
pp. 1180-1190 ◽  
Author(s):  
Yi Sun ◽  
Jian‐Zhong Ai ◽  
Xi Jin ◽  
Liang‐Ren Liu ◽  
Tian‐Hai Lin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Prostate Cancer Cells ◽  
Gsk 3Β

scholarly journals Endothelial Cells Promote Docetaxel Resistance of Prostate Cancer Cells by Inducing ERG Expression and Activating Akt/mTOR Signaling Pathway

2020 ◽  
Vol 10 ◽  
Author(s):  
Wenhao Zhou ◽  
Yiming Su ◽  
Yu Zhang ◽  
Bangmin Han ◽  
Haitao Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Endothelial Cells ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Initial Response ◽  
Mtor Signaling ◽  
Castration Resistant Prostate Cancer ◽  
Mtor Signaling Pathway ◽  
Prostate Cancer Cells ◽  
Docetaxel Resistance

Docetaxel is a first-line chemotherapy for the treatment of patients with castration-resistant prostate cancer (CRPC). Despite the good initial response of docetaxel, drug resistance will inevitably occur. Mechanisms underlying docetaxel resistance are not well elaborated. Endothelial cells (ECs) have been implicated in the progression and metastasis of prostate cancer. However, little attention has been paid to the role of endothelial cells in the development of docetaxel resistance in prostate cancer. Here, we sought to investigate the function and mechanism of endothelial cells involving in the docetaxel resistance of prostate cancer. We found that endothelial cells significantly promoted the proliferation of prostate cancer cells and decreased their sensitivity to docetaxel. Mechanistically, basic fibroblast growth factor (FGF2) secreted by endothelial cells leads to the upregulation of ETS related gene (ERG) expression and activation of the Akt/mTOR signaling pathway in prostate cancer cells to promote docetaxel resistance. In summary, these findings demonstrate a microenvironment-dependent mechanism mediating chemoresistance of prostate cancer and suggest that targeting FGF/FGFR signaling might represent a promising therapeutic strategy to overcome docetaxel resistance.

scholarly journals Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells

2010 ◽  
Vol 31 (8) ◽  
pp. 1424-1433 ◽  
Author(s):  
Y. Suh ◽  
F. Afaq ◽  
N. Khan ◽  
J. J. Johnson ◽  
F. H. Khusro ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Autophagic Cell Death ◽  
Mtor Signaling Pathway ◽  
Prostate Cancer Cells
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