Modulating tumor reactive stroma by extracorporeal shock waves to control prostate cancer progression

The Prostate ◽  
2020 ◽  
Vol 80 (13) ◽  
pp. 1087-1096
Author(s):  
Letizia Rinella ◽  
Benedetta Pizzo ◽  
Roberto Frairia ◽  
Luisa Delsedime ◽  
Giorgio Calleris ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Shock Waves ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Reactive Stroma ◽  
Extracorporeal Shock Waves

REACTIVE STROMA IN PROSTATE CANCER PROGRESSION

2001 ◽  
Vol 166 (6) ◽  
pp. 2472-2483 ◽  
Author(s):  
JENNIFER A. TUXHORN ◽  
GUSTAVO E. AYALA ◽  
DAVID R. ROWLEY
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Reactive Stroma

scholarly journals The reactive stroma microenvironment and prostate cancer progression

2012 ◽  
Vol 19 (6) ◽  
pp. R187-R204 ◽  
Author(s):  
David A Barron ◽  
David R Rowley
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Progression ◽  
Wound Repair ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Tissue Growth ◽  
Prostate Cancer Progression ◽  
Prostate Tumorigenesis ◽  
Reactive Stroma

Reactive stroma initiates during early prostate cancer development and coevolves with prostate cancer progression. Previous studies have defined the key markers of reactive stroma and have established that reactive stroma biology influences prostate tumorigenesis and progression. The stem/progenitor cells of origin and the mechanisms that regulate their recruitment and activation to myofibroblasts or carcinoma-associated fibroblasts are essentially unknown. Key regulatory factors have been identified, including transforming growth factor β, interleukin-8, fibroblast growth factors, connective tissue growth factor, wingless homologs-Wnts, and stromal cell-derived factor-1, among others. The biology of reactive stroma in cancer is similar to the more predictable biology of the stroma compartment during wound repair at sites where the epithelial barrier function is breached and a stromal response is generated. The coevolution of reactive stroma and the biology of how reactive stroma–carcinoma interactions regulate cancer progression and metastasis are targets for new therapeutic approaches. Such approaches are strategically designed to inhibit cancer progression by uncoupling the reactive stroma niche.

scholarly journals Stromal Reactivity Differentially Drives Tumor Cell Evolution and Prostate Cancer Progression

2017 ◽  
Author(s):  
Ziv Frankenstein ◽  
David Basanta ◽  
Omar E. Franco ◽  
Yan Gao ◽  
Rodrigo A. Javier ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Evolutionary Dynamics ◽  
Multiscale Model ◽  
Cell Behavior ◽  
Tumor Evolution ◽  
Tumor Aggressiveness ◽  
Prostate Cancer Progression ◽  
Reactive Stroma ◽  
Clinical Biomarkers

AbstractWe implemented a hybrid multiscale model of carcinogenesis that merges data from biology and pathology on the microenvironmental regulation of prostate cancer (PCa) cell behavior. It recapitulates the biology of stromal influence in prostate cancer progression. Our data indicate that the interactions between the tumor cells and reactive stroma shape the evolutionary dynamics of PCa cells and explain overall tumor aggressiveness. We show that the degree of stromal reactivity, when coupled with the current clinical biomarkers, significantly improves PCa prognostication, both for death and recurrence, that may alter treatment decisions. We also show that stromal reactivity correlates directly with tumor growth but inversely modulates tumor evolution. This suggests that the aggressive stromal independent PCa may be an inevitable evolutionary result of poor stromal reactivity. It also suggests that purely tumor centric metrics of aggressiveness may be misleading in terms on clinical outcome.

REACTIVE STROMA IN PROSTATE CANCER PROGRESSION

2001 ◽  
pp. 2472-2483 ◽  
Author(s):  
JENNIFER A. TUXHORN ◽  
GUSTAVO E. AYALA ◽  
DAVID R. ROWLEY
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Reactive Stroma

463: Telomerase Inhibition Prevents Androgen Independent Osseous Prostate Cancer Progression

2005 ◽  
Vol 173 (4S) ◽  
pp. 126-127
Author(s):  
Yingming Li ◽  
Melissa Thompson ◽  
Zhu Chen ◽  
Bahaa S. Malaeb ◽  
David Corey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Telomerase Inhibition ◽  
Androgen Independent
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