scholarly journals Impact of positive surgical margins on secondary treatment, palliative radiotherapy and prostate cancer‐specific mortality. A population‐based study of 13 198 patients

The Prostate ◽  
2019 ◽  
Vol 79 (16) ◽  
pp. 1852-1860 ◽  
Author(s):  
Rune Kvåle ◽  
Tor Å. Myklebust ◽  
Sophie D. Fosså ◽  
Kirsti Aas ◽  
Christian Ekanger ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Palliative Radiotherapy ◽  
Population Based ◽  
Surgical Margins ◽  
Secondary Treatment ◽  
Population Based Study ◽  
Positive Surgical Margins ◽  
Specific Mortality ◽  
Cancer Specific Mortality

scholarly journals Determinants and effects of positive surgical margins after prostatectomy on prostate cancer mortality: a population-based study

BMC Urology ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Valesca P Retèl ◽  
Christine Bouchardy ◽  
Massimo Usel ◽  
Isabelle Neyroud-Caspar ◽  
Franz Schmidlin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Mortality ◽  
Population Based ◽  
Surgical Margins ◽  
Population Based Study ◽  
Positive Surgical Margins ◽  
Prostate Cancer Mortality

470 DO MARGINS MATTER? THE INFLUENCE OF POSITIVE SURGICAL MARGINS ON PROSTATE CANCER-SPECIFIC MORTALITY

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Andrew J. Stephenson ◽  
Scott E. Eggener ◽  
Eric A. Klein ◽  
Adrian V. Hernandez ◽  
Michael W. Kattan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Surgical Margins ◽  
Positive Surgical Margins ◽  
Specific Mortality ◽  
Cancer Specific Mortality

Do Margins Matter? The Influence of Positive Surgical Margins on Prostate Cancer–Specific Mortality

2014 ◽  
Vol 65 (4) ◽  
pp. 675-680 ◽  
Author(s):  
Andrew J. Stephenson ◽  
Scott E. Eggener ◽  
Adrian V. Hernandez ◽  
Eric A. Klein ◽  
Michael W. Kattan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Surgical Margins ◽  
Positive Surgical Margins ◽  
Specific Mortality ◽  
Cancer Specific Mortality

Racial differences in long-term prostate cancer specific mortality following conservative management for low-risk prostate cancer: A population-based study.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 121-121
Author(s):  
Grace L. Lu-Yao ◽  
Nikita Nikita ◽  
Scott W Keith ◽  
Joshua Banks ◽  
Nathan Handley ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Racial Differences ◽  
Population Based ◽  
Low Risk ◽  
Population Based Study ◽  
Specific Mortality ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer ◽  
Cancer Specific Mortality

121 Background: It is uncertain whether the same criteria for active surveillance can be applied universally across races. This population-based study was undertaken to quantify racial differences in long-term risk of prostate cancer-specific mortality (PCSM) among patients with low-risk prostate cancer (PCa) receiving conservative management. Methods: We used the Surveillance, Epidemiology, and End Results (SEER) database to identify patients who had low-risk PCa (T1-T2a & Gleason 6 & PSA ≤ 10 ng/mL & N0 & M0) diagnosed in 2004 – 2015 and did not receive radical prostatectomy or radiation therapy within one year of diagnosis. Kaplan-Meier analysis was used to calculate PCSM. The Clopper-Pearson method was used to calculate associated 95% confidence intervals. Hazard ratio of PCSM among those with a high PSA (PSA 4-10) compared to those with a low PSA (PSA < 4) was calculated using Cox proportional hazards models adjusted for covariates (including age, race, marital status, insurance status, U.S. region, year of diagnosis, and AJCC clinical tumor stage). Results: Among 33,740 patients with low-risk PCa, long-term PCSM varied with race and PSA levels at diagnosis. For instance, 10-year PCSM was 2.62% (95% CI: 1.15%-5.05%) among African Americans with PSA 4-10 and 0.98% (95% CI:0.16%-3.12%) among Caucasian patients with PSA < 4. There was no significant statistical interaction between race and PSA level on PCSM (p = 0.81). After adjusting for potential confounders, men with PSA 4-10 experienced 2-fold higher PCSM relative to those with PSA < 4 (HR = 1.96, p = 0.011) and African Americans men experienced a 43% higher PCSM compared to Caucasians (HR = 1.43, p = 0.03). Conclusions: Among men diagnosed with low-risk PCa, long-term PCSM varies by race and PSA at diagnosis. More refined risk stratification may improve PCa management among low-risk PCa patients. [Table: see text]

Combination statin/metformin and prostate cancer specific mortality: A population-based study.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 5018-5018 ◽  
Author(s):  
Grace L. Lu-Yao ◽  
Yong Lin ◽  
Dirk Moore ◽  
John Graff ◽  
Antoinette Stroup ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Population Based ◽  
Population Based Study ◽  
Specific Mortality ◽  
Cancer Specific Mortality
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