Extracorporeal shock wave therapy decreases COX‐2 by inhibiting TLR4‐NFκB pathway in a prostatitis rat model

The Prostate ◽  
2019 ◽  
Author(s):  
Seung Hwan Jeon ◽  
Guan Qun Zhu ◽  
Eun Bi Kwon ◽  
Kyu Won Lee ◽  
Hyuk Jin Cho ◽  
...  
Keyword(s):  
Shock Wave ◽  
Rat Model ◽  
Extracorporeal Shock Wave Therapy ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave ◽  
Cox 2 ◽  
Nfκb Pathway

scholarly journals Low-Energy Extracorporeal Shock Wave Therapy Ameliorates Kidney Function in Diabetic Nephropathy

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Chang-Chun Hsiao ◽  
Wei-Han Huang ◽  
Kuang-Hung Cheng ◽  
Chien-Te Lee
Keyword(s):  
Oxidative Stress ◽  
Shock Wave ◽  
Diabetic Nephropathy ◽  
Rat Model ◽  
Renal Fibrosis ◽  
Tissue Repair ◽  
Extracorporeal Shock Wave Therapy ◽  
Low Energy ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave

Background. Diabetic nephropathy is the most common cause of end-stage renal disease. Traditional therapy for diabetic nephropathy has focused on supportive treatment, and there is no significant effective therapy. We investigated the effect of low-energy extracorporeal shock wave therapy on a diabetic nephropathy rat model. Methods. Streptozotocin-induced diabetic nephropathy rats were treated with six sessions of low-energy extracorporeal shock wave therapy (weekly for six consecutive weeks) or left untreated. We assessed urinary creatinine and albumin, glomerular volume, renal fibrosis, podocyte number, renal inflammation, oxidative stress, and tissue repair markers (SDF-1 and VEGF) six weeks after the completion of treatment. Results. The six-week low-energy extracorporeal shock wave therapy regimen decreased urinary albumin excretion as well as reduced glomerular hypertrophy and renal fibrosis in the rat model of diabetic nephropathy. Moreover, low-energy extracorporeal shock wave therapy increased podocyte number in diabetic nephropathy rats. This was likely primarily attributed to the fact that low-energy extracorporeal shock wave therapy reduced renal inflammation and oxidative stress as well as increased tissue repair potency and cell proliferation. Conclusions. Low-energy extracorporeal shock wave therapy preserved kidney function in diabetic nephropathy. Low-energy extracorporeal shock wave therapy may serve as a novel noninvasive and effective treatment of diabetic nephropathy.

scholarly journals Two methods of extracorporeal shock-wave therapy in a rat model of secondary lymphedema: a pilot study

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110244
Author(s):  
Hee Kyung Cho ◽  
Woo Jung Sung ◽  
Youn Ju Lee ◽  
Sang Gyu Kwak ◽  
Kang Lip Kim
Keyword(s):  
Shock Wave ◽  
Rat Model ◽  
Growth Factor Receptor ◽  
Extracorporeal Shock Wave Therapy ◽  
Control Group ◽  
Axillary Lymph ◽  
Sprague Dawley ◽  
Shock Wave Therapy ◽  
Secondary Lymphedema ◽  
Extracorporeal Shock Wave

Objectives To compare the effectiveness of two methods of extracorporeal shock-wave therapy (ESWT) in a rat model of forelimb lymphedema, induced by axillary lymph node dissection. Methods Sprague–Dawley rats were randomly allocated to a group that received 500 ESWT shocks only in the lymphedematous forelimb (Forelimb/ESWT) and a group that received 300 ESWT shocks in the axilla and 200 shocks in the lymphedematous forelimb (Axilla+Forelimb/ESWT). The circumferences of each limb were then measured. Immunohistochemistry for a pan-endothelial marker (cluster of differentiation [CD]31) and lymphatic vessel endothelial hyaluronan receptor-1, and western blot analysis for vascular endothelial growth factor receptor-3 (VEGFR3) and VEGF-C were performed. Results The circumferences of the limbs showed significant effects of group and time following surgery. The circumferences at the carpal joint and 2.5 cm above were smallest in the naïve limbs, larger in the Axilla+Forelimb/ESWT group, and the largest in the control group. VEGFR3 tended to be expressed at a higher level in the Axilla+Forelimb/ESWT group (1.96-fold) than in the Forelimb/ESWT group (1.20-fold) versus the opposite non-edematous forelimbs, although this difference was not statistically significant. Conclusions These data suggest that ESWT protocols have differential effects on angiogenesis and lymphangiogenesis in lymphedematous limbs.

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