An IL‐2 proaerolysin fusion toxin that selectively eliminates regulatory t cells to enhance antitumor immune response

The Prostate ◽  
2019 ◽  
Vol 79 (10) ◽  
pp. 1071-1078
Author(s):  
Oliver Rogers ◽  
Hung Yen ◽  
Anna Solomon ◽  
Charles Drake ◽  
Samuel Denmeade
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Regulatory T Cells ◽  
Antitumor Immune Response ◽  
Fusion Toxin

scholarly journals IFN-γ Controls the Generation/Activation of CD4+CD25+ Regulatory T Cells in Antitumor Immune Response

2005 ◽  
Vol 175 (7) ◽  
pp. 4433-4440 ◽  
Author(s):  
Hiroyoshi Nishikawa ◽  
Takuma Kato ◽  
Isao Tawara ◽  
Hiroaki Ikeda ◽  
Kagemasa Kuribayashi ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Regulatory T Cells ◽  
Antitumor Immune Response ◽  
Ifn Γ

scholarly journals Characteristics of Regulatory T cells

2016 ◽  
Vol 85 (4) ◽  
pp. 323-326
Author(s):  
Magdalena Frydrychowicz ◽  
Maciej Boruczkowski ◽  
Agata Kolecka-Bednarczyk ◽  
Renata Jenek ◽  
Joanna Rosołowska ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Regulatory T Cells ◽  
Adhesion Molecules ◽  
Chemokine Receptors ◽  
Toll Like Receptors ◽  
Effector Cells

Regulatory T cells (Tregs) is heterogenic subpopulation of T cells that is able to suppress function of effector cells during the immune response. Among them are natural (nTreg) and induced Treg (Tr1, Th3, CD4+CD25-). CD25, CD45Ro, CD152, GITR, LAG-3, several adhesion molecules, chemokine receptors as well as Toll-like receptors are present on the surface of Treg. Mechanism of suppression used by nTreg is not completely understood.

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