Combined maternal and post‐weaning high fat diet inhibits male offspring's prostate cancer tumorigenesis in transgenic adenocarcinoma of mouse prostate model

The Prostate ◽  
2019 ◽  
Vol 79 (5) ◽  
pp. 544-553 ◽  
Author(s):  
Yufei Liu ◽  
Xiaobo Wu ◽  
Haowen Jiang
Keyword(s):  
Prostate Cancer ◽  
High Fat Diet ◽  
High Fat ◽  
Mouse Prostate

scholarly journals Maternal High-Fat Diet Promotes the Development and Progression of Prostate Cancer in Transgenic Adenocarcinoma Mouse Prostate Offspring

2018 ◽  
Vol 47 (5) ◽  
pp. 1862-1870 ◽  
Author(s):  
Tian Yang ◽  
Xiaobo Wu ◽  
Jimeng Hu ◽  
Mengbo Hu ◽  
Hua Xu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mortality Rate ◽  
High Fat Diet ◽  
Formation Rate ◽  
Serum Levels ◽  
Normal Diet ◽  
Tumor Formation ◽  
High Fat ◽  
Mouse Prostate ◽  
The Impact

Background/Aims: We aim to investigate the impact of maternal high fat diet (HFD) on the development and progression of prostate cancer (PCa) in transgenic adenocarcinoma mouse prostate (TRAMP) offspring. Methods: The TRAMP model was used, and divided into maternal HFD group and normal diet (ND) group in the present study. Each group contained 36 TRAMP mice. Serum levels of leptin, adiponectin, interleukin (IL) -1α, IL-1β, IL-6, tumor necrosis factor-α and monocyte chemotactic protein-1 were measured by the 20th, 24th and 28th week old through ProcartaPlex Multiplex Immunoassay. Body fat ratio was measured by MiniQMR. Tumor formation rate was measured through hematoxylin and eosin (H&E) staining, and mortality rate was measured meantime. Western blot was applied to determine the levels of Protein Kinase B (Akt) and Phosphatase and tensin homolog (PTEN). Results: The mortality rate of maternal HFD group was significantly higher than that of ND group (P = 0.046). The tumor formation rate was significantly higher in maternal HFD group than in ND group only in 20th week subgroup (P = 0.040). A significant increase of leptin was seen in maternal HFD 20th and 24th week subgroups (P = 0.001 and < 0.001, respectively) and a decrease of adiponectin was seen in maternal HFD 20th and 28th week subgroups (P =0.006 and < 0.001, respectively). Besides, an activated phos-Akt (P-Akt) and deactivated PTEN were observed in maternal HFD group. Conclusions: Maternal HFD could increase the standard serum leptin level, inhibit the expression of PTEN protein, promote P-Akt protein expression, activate the PI3K/Akt pathway, and ultimately promote the development and progression of PCa in TRAMP offspring.

scholarly journals 3,3′-Diindolylmethane Dose-Dependently Prevents Advanced Prostate Cancer

2019 ◽  
Author(s):  
Yufei Li ◽  
Nathaniel W. Mahloch ◽  
Nicholas J.E. Starkey ◽  
Mónica Peña-Luna ◽  
George E. Rottinghaus ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
High Fat Diet ◽  
Estrogen Receptor Alpha ◽  
Estrogen Receptor Beta ◽  
Control Group ◽  
High Fat ◽  
Mouse Prostate

Abstract3,3′-Diindolylmethane (DIM) is an acid-derived dimer of indole-3-carbinol, found in many cruciferous vegetables, such as broccoli, and has been shown to inhibit prostate cancer (PCa) in several in vitro and in vivo models. We demonstrated that DIM stimulated both estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) transcriptional activities and propose that ERβ plays a role in mediating DIM’s inhibition on cancer cell growth. To further study the effects of DIM on inhibiting advanced PCa development, we tested DIM in TRAMP (TRansgenic Adenocarcinoma of the Mouse Prostate) mice. The control group of mice were fed a high fat diet. Three additional groups of mice were fed the same high fat diet supplemented with 0.04%, 0.2% and 1% DIM. Incidence of advanced PCa, poorly differentiated carcinoma (PDC), in the control group was 60%. 1% DIM dramatically reduced PDC incidence to 24% (p=0.0012), while 0.2% and 0.04% DIM reduced PDC incidence to 38% (p=0.047) and 45% (p=0.14) respectively. Though DIM did affect mice weights, statistical analysis showed a clear negative association between DIM concentration and PDC incidence with p=0.004, while the association between body weight and PDC incidence was not significant (p=0.953). In conclusion, our results show that dietary DIM can inhibit the most aggressive stage of prostate cancer at concentration lower than previously demonstrated, possibly working through an estrogen receptor mediated mechanism.

Will metformin postpone high-fat diet promotion of TRAMP mouse prostate cancer development and progression?

2014 ◽  
Vol 46 (12) ◽  
pp. 2327-2334 ◽  
Author(s):  
Hua Xu ◽  
Meng-bo Hu ◽  
Pei-de Bai ◽  
Wen-hui Zhu ◽  
Qiang Ding ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Fat Diet ◽  
Cancer Development ◽  
High Fat ◽  
Tramp Mouse ◽  
Mouse Prostate ◽  
Prostate Cancer Development

scholarly journals Metformin inhibits prostate cancer growth induced by a high‐fat diet inPten‐deficient model mice

2018 ◽  
Vol 26 (2) ◽  
pp. 307-309 ◽  
Author(s):  
Takuji Hayashi ◽  
Kazutoshi Fujita ◽  
Makoto Matsushita ◽  
Yujiro Hayashi ◽  
Motohide Uemura ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Fat Diet ◽  
Cancer Growth ◽  
High Fat

244 MiR-130a modulates high-fat diet-induced tumour progression through the activation of MET in prostate cancer

2016 ◽  
Vol 15 (3) ◽  
pp. e244
Author(s):  
S. Narita ◽  
Y. Matsuda ◽  
T. Nara ◽  
M. Huang ◽  
T. Yoshioka ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Fat Diet ◽  
Tumour Progression ◽  
High Fat

Abstract 2674: High fat diet accelerates MYC-driven prostate cancer through metabolic and epigenomic rewiring

2016 ◽  
Author(s):  
David P. Labbe’ ◽  
Giorgia Zadra ◽  
Meng Yang ◽  
Charles Y. Lin ◽  
Jaime M. Reyes ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Fat Diet ◽  
High Fat

Abstract B39: PTP1B deficiency potentiate prostate cancer invasiveness by sensitizing Pten-null tumors to high-fat diet

2016 ◽  
Author(s):  
David P. Labbé ◽  
Noriko Uetani ◽  
Valérie Vinette ◽  
Isabelle Aubry ◽  
Eva Migon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Fat Diet ◽  
High Fat ◽  
Cancer Invasiveness
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