Association of anti‐inflammatory and antiangiogenic therapies negatively influences prostate cancer progression in TRAMP mice

The Prostate ◽  
2018 ◽  
Vol 79 (5) ◽  
pp. 515-535 ◽  
Author(s):  
Pedro Augusto Marischka Mateus ◽  
Larissa Akemi Kido ◽  
Rafael Sauce Silva ◽  
Valéria Helena Alves Cagnon ◽  
Fabio Montico
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Antiangiogenic Therapies ◽  
Anti Inflammatory ◽  
Tramp Mice

scholarly journals Main Inflammatory Cells and Potentials of Anti-Inflammatory Agents in Prostate Cancer

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1153 ◽  
Author(s):  
Takuji Hayashi ◽  
Kazutoshi Fujita ◽  
Makoto Matsushita ◽  
Norio Nonomura
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Immune Cells ◽  
Acquired Resistance ◽  
Suppressor Cells ◽  
Basic Research ◽  
Inflammatory Cells ◽  
Intercellular Signaling ◽  
Prostate Cancer Progression ◽  
Anti Inflammatory

Prostate cancer is the most common type of cancer and the leading cause of cancer deaths among men in many countries. Preventing progression is a major concern for prostate cancer patients on active surveillance, patients with recurrence after radical therapies, and patients who acquired resistance to systemic therapies. Inflammation, which is induced by various factors such as infection, microbiome, obesity, and a high-fat diet, is the major etiology in the development of prostate cancer. Inflammatory cells play important roles in tumor progression. Various immune cells including tumor-associated neutrophils, tumor-infiltrating macrophages, myeloid-derived suppressor cells, and mast cells promote prostate cancer via various intercellular signaling. Further basic studies examining the relationship between the inflammatory process and prostate cancer progression are warranted. Interventions by medications and diets to control systemic and/or local inflammation might be effective therapies for prostate cancer progression. Epidemiological investigations and basic research using human immune cells or mouse models have revealed that non-steroidal anti-inflammatory drugs, metformin, statins, soy isoflavones, and other diets are potential interventions for preventing progression of prostate cancer by suppressing inflammation. It is essential to evaluate appropriate indications and doses of each drug and diet.

Abstract 4327: Dietary tomato reduces castration-resistant prostate cancer progression in TRAMP mice

2016 ◽  
Author(s):  
Joshua W. Smith ◽  
Joe L. Rowles ◽  
Rita J. Miller ◽  
Steven K. Clinton ◽  
William D. O’Brien ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Tramp Mice

scholarly journals Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway

2013 ◽  
Vol 35 (2) ◽  
pp. 452-460 ◽  
Author(s):  
S. Shukla ◽  
N. Bhaskaran ◽  
M. A. Babcook ◽  
P. Fu ◽  
G. T. MacLennan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Tramp Mice

High animal fat intake enhances prostate cancer progression and reduces glutathione peroxidase 3 expression in early stages of TRAMP mice

The Prostate ◽  
2014 ◽  
Vol 74 (13) ◽  
pp. 1266-1277 ◽  
Author(s):  
Seo-Na Chang ◽  
Juhee Han ◽  
Tamer Said Abdelkader ◽  
Tae-Hyoun Kim ◽  
Ji Min Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Glutathione Peroxidase ◽  
Cancer Progression ◽  
Fat Intake ◽  
Prostate Cancer Progression ◽  
High Animal ◽  
Animal Fat ◽  
Early Stages ◽  
Glutathione Peroxidase 3 ◽  
Tramp Mice

scholarly journals Deregulation of FoxO3a accelerates prostate cancer progression in TRAMP mice

The Prostate ◽  
2013 ◽  
Vol 73 (14) ◽  
pp. 1507-1517 ◽  
Author(s):  
Sanjeev Shukla ◽  
Natarajan Bhaskaran ◽  
Gregory T. MacLennan ◽  
Sanjay Gupta
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Tramp Mice

scholarly journals Icaritin reduces prostate cancer progression via inhibiting high-fat diet-induced serum adipokine in TRAMP mice model

2020 ◽  
Vol 11 (22) ◽  
pp. 6556-6564
Author(s):  
Xiaobo Wu ◽  
Xingbo Long ◽  
Chen Yang ◽  
Huan Chen ◽  
Christina Sharkey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
High Fat Diet ◽  
Prostate Cancer Progression ◽  
Mice Model ◽  
High Fat ◽  
Tramp Mice
Sign in / Sign up

Export Citation Format

Share Document