scholarly journals Differential expression of Annexin 2, SPINK1, and Hsp60 predict progression of prostate cancer through bifurcated WHO Gleason score categories in African American men

The Prostate ◽  
2018 ◽  
Vol 78 (11) ◽  
pp. 801-811 ◽  
Author(s):  
Desta A. Beyene ◽  
Tammey J. Naab ◽  
Norma F. Kanarek ◽  
Victor Apprey ◽  
Ashwini Esnakula ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Differential Expression ◽  
Gleason Score ◽  
African American Men ◽  
Annexin 2

Impact of Race on Prostate-Specific Antigen Outcome After Radical Prostatectomy for Clinically Localized Adenocarcinoma of the Prostate

2002 ◽  
Vol 20 (12) ◽  
pp. 2863-2868 ◽  
Author(s):  
Chaundre K. Cross ◽  
Delray Shultz ◽  
S. Bruce Malkowicz ◽  
William C. Huang ◽  
Richard Whittington ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
High Risk ◽  
Gleason Score ◽  
Risk Group ◽  
African American Men ◽  
Specific Antigen ◽  
White Men ◽  
Risk Groups ◽  
T Stage

PURPOSE: To compare prostate-specific antigen (PSA) outcome after radical prostatectomy (RP) for prostate cancer in African-American and white men using previously established risk groups. PATIENTS AND METHODS: Between 1989 and 2000, 2,036 men (n = 162 African-American men, n = 1,874 white men) underwent RP for clinically localized prostate cancer. Using pretreatment PSA, Gleason score, clinical T stage, and percentage of positive biopsy specimens, patients were stratified into low- and high-risk groups. For each risk group, PSA outcome was estimated using the actuarial method of Kaplan and Meier. Comparisons of PSA outcome between African-American and white men were made using the log-rank test. RESULTS: The median age and PSA level for African-American and white men were 60 and 62 years old and 8.8 and 7.0 ng/mL, respectively. African-Americans had a statistically significant increase in PSA (P = .002), Gleason score (P = .003), clinical T stage (P = .004), and percentage of positive biopsy specimens (P = .04) at presentation. However, there was no statistical difference in the distribution of PSA, clinical T stage, or Gleason score between racial groups in the low- and high-risk groups. The 5-year estimate of PSA outcome was 87% in the low-risk group for all patients (P = .70) and 28% versus 32% in African-American and white patients in the high-risk group (P = .28), respectively. Longer follow-up is required to confirm if these results are maintained at 10 years. CONCLUSION: Even though African-American men presented at a younger age and with more advanced disease compared with white men with prostate cancer, PSA outcome after RP when controlled for known clinical predictive factors was not statistically different. This study supports earlier screening in African-American men.

627: Racial Differences in Tumor Volume and Gleason Score in T1c Prostate Cancer: Additional Evidence for Lowering the PSA Threshold for Biopsy in African American Men

2004 ◽  
Vol 171 (4S) ◽  
pp. 167-167
Author(s):  
Ricardo F. Sanchez-Ortiz ◽  
Curtis A. Pettaway ◽  
Richard J. Babaian ◽  
Jose Lloreta ◽  
Dennis Johnston ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Racial Differences ◽  
Gleason Score ◽  
Tumor Volume ◽  
African American Men
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