Chronic Pelvic Pain Development and Prostate Inflammation in Strains of Mice With Different Susceptibility to Experimental Autoimmune Prostatitis

The Prostate ◽  
2016 ◽  
Vol 77 (1) ◽  
pp. 94-104 ◽  
Author(s):  
Maria L. Breser ◽  
Ruben D. Motrich ◽  
Leonardo R. Sanchez ◽  
Virginia E. Rivero
Keyword(s):  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Prostate Inflammation ◽  
Experimental Autoimmune

Effect of tadalafil on chronic pelvic pain and prostatic inflammation in a rat model of experimental autoimmune prostatitis

The Prostate ◽  
2018 ◽  
Vol 78 (10) ◽  
pp. 707-713 ◽  
Author(s):  
Ken Okamoto ◽  
Maki Kurita ◽  
Hiroshi Yamaguchi ◽  
Yuki Numakura ◽  
Michiko Oka
Keyword(s):  
Pelvic Pain ◽  
Rat Model ◽  
Chronic Pelvic Pain ◽  
Prostatic Inflammation ◽  
Experimental Autoimmune

Chronic Prostate Inflammation Predicts Symptom Progression in Patients with Chronic Prostatitis/Chronic Pelvic Pain

2017 ◽  
Vol 198 (1) ◽  
pp. 122-128 ◽  
Author(s):  
J. Curtis Nickel ◽  
Stephen J. Freedland ◽  
Ramiro Castro-Santamaria ◽  
Daniel M. Moreira
Keyword(s):  
Pelvic Pain ◽  
Chronic Prostatitis ◽  
Chronic Pelvic Pain ◽  
Prostate Inflammation ◽  
Symptom Progression

Experimental autoimmune prostatitis induces chronic pelvic pain

2008 ◽  
Vol 294 (4) ◽  
pp. R1268-R1275 ◽  
Author(s):  
Charles N. Rudick ◽  
Anthony J. Schaeffer ◽  
Praveen Thumbikat
Keyword(s):  
Chronic Pain ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Protein Gene Product ◽  
Mouse Prostate ◽  
Inflammatory Infiltrates ◽  
Experimental Autoimmune

Pain is the hallmark of patients with chronic prostatitis (CP) and chronic pelvic pain syndrome (CPPS). Despite numerous hypotheses, the etiology and pathogenesis remain unknown. To better understand CP/CPPS, we used a murine experimental autoimmune prostatitis model to examine the development, localization, and modulation of pelvic pain. Pelvic pain was detected 5 days after antigen instillation and was sustained beyond 30 days, indicating the development of chronic pain. The pain was attenuated by lidocaine treatment into the prostate, but not into the bladder or the colon, suggesting that pain originated from the prostate. Experimental autoimmune prostatitis histopathology was confined to the prostate with focal periglandular inflammatory infiltrates in the ventral, dorsolateral, and anterior lobes of the mouse prostate. Inflammation and pelvic pain were positively correlated and increased with time. Morphologically, the dorsolateral prostate alone showed significantly increased neuronal fiber distribution, as evidenced by increased protein gene product 9.5 expression. Pelvic pain was attenuated by treatment with the neuromodulator gabapentin, suggesting spinal and/or supraspinal contribution to chronic pain. These results provide the basis for identifying mechanisms that regulate pelvic pain and the testing of therapeutic agents that block pain development in CP/CPPS.

scholarly journals Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome

Pain ◽  
2014 ◽  
Vol 155 (7) ◽  
pp. 1328-1338 ◽  
Author(s):  
Kenny Roman ◽  
Joseph D. Done ◽  
Anthony J. Schaeffer ◽  
Stephen F. Murphy ◽  
Praveen Thumbikat
Keyword(s):  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Chronic Pelvic Pain Syndrome ◽  
Pain Syndrome ◽  
Pelvic Pain Syndrome ◽  
Experimental Autoimmune

Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis

The Prostate ◽  
2019 ◽  
Vol 79 (12) ◽  
pp. 1466-1476 ◽  
Author(s):  
Li‐Gang Zhang ◽  
Jing Chen ◽  
Jia‐Lin Meng ◽  
Yong Zhang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Pelvic Pain ◽  
Chronic Pelvic Pain ◽  
Prostatic Inflammation ◽  
Experimental Autoimmune
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