Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients

The Prostate ◽  
2016 ◽  
Vol 76 (14) ◽  
pp. 1239-1256 ◽  
Author(s):  
Ahva Shahabi ◽  
Juan Pablo Lewinger ◽  
Jie Ren ◽  
Craig April ◽  
Andy E. Sherrod ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Early Stage ◽  
Gene Expression Signature ◽  
Clinical Recurrence ◽  
Expression Signature ◽  
Novel Gene

scholarly journals Gene expression signature of Gleason score is associated with prostate cancer outcomes in a radical prostatectomy cohort

Oncotarget ◽  
2017 ◽  
Vol 8 (26) ◽  
pp. 43035-43047 ◽  
Author(s):  
Min A. Jhun ◽  
Milan S. Geybels ◽  
Jonathan L. Wright ◽  
Suzanne Kolb ◽  
Craig April ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Gene Expression Signature ◽  
Cancer Outcomes ◽  
Expression Signature

730 THE ATORVASTATIN TARGET SCD1 IDENTIFIED WITHIN THE GENE EXPRESSION SIGNATURE OF HIGH BMI PROSTATE CANCER PATIENTS

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Patrick Parker ◽  
Shashwat Sharad ◽  
Anjali Srivastava ◽  
Suma Ravulapalli ◽  
Yongmei Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Patients ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
High Bmi

Generation of a prognostic cancer stem-like gene expression signature in men undergoing radical prostatectomy for localized prostate cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 4563-4563
Author(s):  
Adrian Stuart Fairey ◽  
Dongyun Yang ◽  
Susan G. Groshen ◽  
David I. Quinn ◽  
Philip Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Wnt Signaling Pathway ◽  
Gene Expression Signature ◽  
Disease Recurrence ◽  
Localized Prostate Cancer ◽  
Mrna Levels ◽  
Expression Signature

4563 Background: Novel biomarkers are needed to predict recurrence after radical prostatectomy for localized prostate cancer. Recent data suggest that cancer stem-like cells (CSC) are present in prostate tumors, and the CSC phenotype has been associated with an aggressive cancer phenotype. We investigated whether tumor mRNA levels of genes typically expressed by CSC are associated with disease recurrence. Methods: Clinically annotated prostatectomy specimens (FFPE) were used for this nested case-control study. Samples represented men who underwent radical prostatectomy and either experienced a recurrence (PSA or clinical; n=152) or no recurrence (controls; n=124) with minimum 5-year follow-up. Men were excluded if they received neoadjuvant hormone therapy. Cases and controls were frequency matched based on D’Amico risk group. Laser capture microdissection with mRNA extraction and quantitative RT-PCR were used to quantify the expression of 12 candidate CSC-associated genes (ALDH1A1, Axin2, Bmi1, CD133, CD44a, CTNNB1/β-catenin, ITGA2/integrin α2, NANOG, Nkx3-1, Notch1, OCT 4, TACSTD2/Trop2). Univariable and multivariable analyses were conducted to measure associations with recurrence. Results: mRNA data were evaluable for 241 of 276 patients. Univariate Wilcoxon analysis showed that 4 genes (Axin2, p<0.001; CD44a, p=0.036; OCT 4, p=0.017; TACSTD2, p=0.008) were expressed at low levels in tumors of patients whose disease recurred. Recursive partitioning analysis identified 3 genes significantly predictive of disease recurrence (Axin2, NANOG, CTNNB1), with cutpoints yielding odds ratios (OR) of 8.5 (Axin2low/NANOGhigh; n=94, 95%CI 3.7-19.2) and 5.1 (Axin2low/NANOGvery high/CTNNB1low; n=26, 95%CI 1.7-14.8). Conclusions: We identified a novel CSC-associated 3 gene expression signature with the potential to predict recurrence after radical prostatectomy. Axin2 is known to interact with CTNNB1/β-catenin in the Wnt signaling pathway, which in turn has been shown to regulate expression of NANOG, a key protein that mediates pluripotency. In vitro experiments and an independent cohort validation study are planned based on these novel findings.

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