scholarly journals Carotenoid intake and adipose tissue carotenoid levels in relation to prostate cancer aggressiveness among African-American and European-American men in the North Carolina-Louisiana prostate cancer project (PCaP)

The Prostate ◽  
2016 ◽  
Vol 76 (12) ◽  
pp. 1053-1066 ◽  
Author(s):  
Samuel O. Antwi ◽  
Susan E. Steck ◽  
L. Joseph Su ◽  
James R. Hebert ◽  
Hongmei Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
North Carolina ◽  
Adipose Tissue ◽  
African American ◽  
European American ◽  
The North ◽  
Cancer Aggressiveness ◽  
Cancer Project

scholarly journals GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP)

The Prostate ◽  
2010 ◽  
Vol 71 (8) ◽  
pp. 881-891 ◽  
Author(s):  
Zongli Xu ◽  
Jeannette T. Bensen ◽  
Gary J. Smith ◽  
James L. Mohler ◽  
Jack A. Taylor
Keyword(s):  
Prostate Cancer ◽  
North Carolina ◽  
African American ◽  
European American ◽  
The North ◽  
Cancer Project

scholarly journals Understanding the Relationship between Environmental Arsenic and Prostate Cancer Aggressiveness among African-American and European-American Men in North Carolina

2020 ◽  
Vol 17 (22) ◽  
pp. 8364
Author(s):  
Humberto Parada ◽  
Tianying Wu ◽  
Rebecca C. Fry ◽  
Laura Farnan ◽  
Gary J. Smith ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
North Carolina ◽  
African American ◽  
African American Men ◽  
European American ◽  
Total Arsenic ◽  
Cross Sectional ◽  
Low Level ◽  
Cancer Aggressiveness ◽  
Arsenical Species

High-level exposure to arsenic, a known carcinogen and endocrine disruptor, is associated with prostate cancer (PCa) mortality. Whether low-level exposure is associated with PCa aggressiveness remains unknown. We examined the association between urinary arsenic and PCa aggressiveness among men in North Carolina. This cross-sectional study included 463 African-American and 491 European-American men with newly diagnosed, histologically confirmed prostate adenocarcinoma. PCa aggressiveness was defined as low aggressive (Gleason score < 7, stage = cT1–cT2, and PSA < 10 ng/mL) versus intermediate/high aggressive (all other cases). Total arsenic and arsenical species (inorganic arsenic (iAsIII + iAsV), arsenobetaine, monomethyl arsenic, and dimethyl arsenic)) and specific gravity were measured in spot urine samples obtained an average of 23.7 weeks after diagnosis. Multivariable logistic regression was used to estimate the covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for PCa aggressiveness in association with arsenic tertiles/quantiles overall and by race. The highest (vs. lowest) tertile of total arsenic was associated with PCa aggressiveness ORs of 1.77 (95% CI = 1.05–2.98) among European-American men, and 0.94 (95% CI = 0.57–1.56) among African-American men (PInteraction = 0.04). In contrast, total arsenic and arsenical species were not associated with PCa aggressiveness in unstratified models. Low-level arsenic exposure may be associated with PCa aggressiveness among European-Americans, but not among African-Americans.

Sign in / Sign up

Export Citation Format

Share Document