scholarly journals Implications and considerations of thermal effects when applying irreversible electroporation tissue ablation therapy

The Prostate ◽  
2015 ◽  
Vol 75 (10) ◽  
pp. 1114-1118 ◽  
Author(s):  
Rafael V. Davalos ◽  
Suyashree Bhonsle ◽  
Robert E. Neal
Keyword(s):  
Thermal Effects ◽  
Irreversible Electroporation ◽  
Tissue Ablation ◽  
Ablation Therapy

A Study of the Immunological Response to Tumor Ablation with Irreversible Electroporation

2007 ◽  
Vol 6 (4) ◽  
pp. 301-305 ◽  
Author(s):  
B. Al-Sakere ◽  
C. Bernat ◽  
F. André ◽  
E. Connault ◽  
P. Opolon ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Cells ◽  
Thermal Effects ◽  
Immune Cell ◽  
Irreversible Electroporation ◽  
Immunological Response ◽  
Tissue Ablation ◽  
Cell Recruitment ◽  
Electrical Fields ◽  
Immune Cell Recruitment

Immune cell recruitment during the treatment of sarcoma tumors in mice with irreversible electroporation was studied by immunohistochemistry. Irreversible electroporation is a non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale defects in the membrane. Employing irreversible electroporation parameters known to completely ablate the tumors without thermal effects we did not find infiltration of immune cells probably because of the destruction of infiltration routes. We confirm here that immune response is not instrumental in irreversible electroporation efficacy, and we propose that irreversible electroporation may be, therefore, a treatment modality of interest to immunodepressed cancer patients.

Safety and efficacy of magnetic anchoring electrode-assisted irreversible electroporation for gastric tissue ablation

2019 ◽  
Vol 34 (2) ◽  
pp. 580-589 ◽  
Author(s):  
Fenggang Ren ◽  
Qingshan Li ◽  
Liangshuo Hu ◽  
Xiaopeng Yan ◽  
Zhongyang Gao ◽  
...  
Keyword(s):  
Irreversible Electroporation ◽  
Tissue Ablation ◽  
Gastric Tissue ◽  
Safety And Efficacy

Irreversible electroporation (IRE): a novel method for renal tissue ablation

2010 ◽  
Vol 107 (12) ◽  
pp. 1982-1987 ◽  
Author(s):  
Chad R. Tracy ◽  
Wareef Kabbani ◽  
Jeffrey A. Cadeddu
Keyword(s):  
Irreversible Electroporation ◽  
Renal Tissue ◽  
Tissue Ablation ◽  
Novel Method

scholarly journals Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablation

2016 ◽  
Author(s):  
Nina Klein ◽  
Enric Guenther ◽  
Paul Mikus ◽  
Michael K Stehling ◽  
Boris Rubinsky
Keyword(s):  
Electric Fields ◽  
Exponential Decay ◽  
Irreversible Electroporation ◽  
Tissue Ablation ◽  
Electrical Currents ◽  
New Device ◽  
Reversible Electroporation ◽  
Electrolytic Ablation ◽  
Synergistic Combination ◽  
Single Exponential

Background: Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study we explore the attributes of a new tissue ablation technology that simultaneously delivers a synergistic combination of electroporation and electrolysis (E2). Method: A new device that delivers a controlled dose of electroporation field and electrolysis currents in the form of a single exponential decay waveform (EDW), was applied to the pig liver and the effect of various parameters on the extent of tissue ablation was examined with histology. Results: Histological analysis shows that E2 delivered as EDW can produce tissue ablation in volumes of clinical significance, using electrical and temporal parameters which, if used in electroporation or electrolysis separately, cannot ablate the tissue Discussion: The E2 combination has advantages over the three basic technologies of non-thermal ablation: electrolytic ablation, electrochemical ablation (reversible electroporation with injection of drugs) and irreversible electroporation. E2 ablates clinically relevant volumes of tissue in a shorter period of time than electrolysis and electroporation, without the need to inject drugs as in reversible electroporation or use paralyzing anesthesia as in irreversible electroporation.

Feasibility Study for Applying Irreversible Electroporation to the Treatment of Breast Cancer

2009 ◽  
Author(s):  
Robert E. Neal ◽  
Ravi Singh ◽  
Suzy Torti ◽  
Rafael V. Davalos
Keyword(s):  
Breast Cancer ◽  
Immune Response ◽  
Extracellular Matrix ◽  
Numerical Modeling ◽  
Cell Membrane ◽  
Irreversible Electroporation ◽  
Short Length ◽  
Tissue Ablation ◽  
Electric Pulses ◽  
A Cell

Non-thermal irreversible electroporation (IRE) is a new, minimally invasive, localized tissue ablation technique [1]. The procedure uses electrodes to deliver short-length, high voltage electric pulses to destabilize a cell membrane, leading to the creation of nanopores. When the pulses are strong enough, the cell cannot repair the damage and dies [2]. It has been shown that substantial volumes of tissue and cutaneous tumors may be ablated in a non-thermal manner using irreversible electroporation [1, 3]. In addition, this procedure may be predicted by numerical modeling, promotes an immune response, leaves the extracellular matrix intact, does not affect nerves, may be monitored in real-time, and preserves tissue vasculature [2–5].

scholarly journals Assessment of Ablation Therapy in Pancreatic Cancer: The Radiologist’s Challenge

2020 ◽  
Vol 10 ◽  
Author(s):  
Vincenza Granata ◽  
Roberta Grassi ◽  
Roberta Fusco ◽  
Sergio Venanzio Setola ◽  
Raffaele Palaia ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Radiofrequency Ablation ◽  
Irreversible Electroporation ◽  
Experimental Studies ◽  
Evaluation Criteria ◽  
Treatment Modalities ◽  
Position Emission Tomography ◽  
Complication Rates ◽  
Ablation Therapy ◽  
Ablative Therapies

This article provides an overview of imaging assessment of ablated pancreatic cancer. Only studies reporting radiological assessment on pancreatic ablated cancer were retained. We found 16 clinical studies that satisfied the inclusion criteria. Radiofrequency ablation and irreversible electroporation have become established treatment modalities because of their efficacy, low complication rates, and availability. Microwave Ablation (MWA) has several advantages over radiofrequency ablation (RFA), which may make it more attractive to treat pancreatic cancer. Electrochemotherapy (ECT) is a very interesting emerging technique, characterized by low complication rate and safety profile. According to the literature, the assessment of the effectiveness of ablative therapies is difficult by means of the Response Evaluation Criteria in Solid Tumors (RECIST) criteria that are not suitable to evaluate the treatment response considering that are related to technique used, the timing of reassessment, and the imaging procedure being used to evaluate the efficacy. RFA causes various appearances on imaging in the ablated zone, correlating to the different effects, such as interstitial edema, hemorrhage, carbonization, necrosis, and fibrosis. Irreversible electroporation (IRE) causes the creation of pores within the cell membrane causing cell death. Experimental studies showed that Diffusion Weigthed Imaging (DWI) extracted parameters could be used to detect therapy effects. No data about functional assessment post MWA is available in literature. Morphologic data extracted by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) do not allow to differentiate partial, complete, or incomplete response after ECT conversely to functional parameters, obtained with Position Emission Tomography (PET), MRI, and CT.

scholarly journals Irreversible Electroporation: Implications for Prostate Ablation

2007 ◽  
Vol 6 (4) ◽  
pp. 295-300 ◽  
Author(s):  
Gary Onik ◽  
Paul Mikus ◽  
Boris Rubinsky
Keyword(s):  
Irreversible Electroporation ◽  
Neurovascular Bundle ◽  
Tissue Ablation ◽  
Pulse Interval ◽  
Short Pulses ◽  
Voltage Range ◽  
Thermal Lesions ◽  
Primary Prostate Cancer ◽  
Adjacent Structures ◽  
Cryo Ablation

Percutaneous prostate cryo-ablation has become an accepted treatment for primary prostate cancer. Thermal tissue ablation based on cold, however, does have some distinct limitations. These include, variable damage at the cryo lesions margin, injury to adjacent structures such as rectum, urethra and NVB (neurovascular bundle), and long procedure time due to the need for multiple freeze thaw cycles, that have limited the acceptance of this modality. Irreversible electroporation IRE, is a new non-thermal ablation modality that uses short pulses of DC electric current to create irreversible pore in the cell membrane, thus, causing cell death. This method theoretically should have significant advantages in ablating prostate tissue. Six males dogs had their prostates treated using IRE. Pulses were applied using a DC generator that delivered pulses in the microsecond range of duration, with a variable pulse interval and voltage range. IRE probes were placed percutaneously or trans-rectally using trans-rectal ultrasound guidance. In one of the dogs, the lesions were made purposely to include the rectum, urethra, and neurovascular bundle (NVB). Subjects were followed for 1 to 14 days before sacrifice. IRE lesions in the prostate had unique characteristics compared to thermal lesions. The margins of the IRE lesions was very distinct with a narrow zone of transition from normal to complete necrosis, there was complete destruction within the IRE lesion, and rapid resolution of the lesions with marked shrinkage within two weeks. Structures such as urethra, vessels, nerves, and rectum were unaffected by the IRE application. IRE lesions have characteristics that are distinctly different than thermal lesions. The differences could be very advantageous in a clinical setting, improving the results and acceptance of prostate ablation.

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