TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer

The Prostate ◽  
2014 ◽  
Vol 74 (12) ◽  
pp. 1161-1170 ◽  
Author(s):  
Isabel Drake ◽  
Peter Wallström ◽  
George Hindy ◽  
Ulrika Ericson ◽  
Bo Gullberg ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Type 2 Diabetes ◽  
Lifestyle Factors ◽  
Diabetes Risk ◽  
Risk Variant

scholarly journals No Association of Type 2 Diabetes Risk Variants and Prostate Cancer Risk: the Multiethnic Cohort and PAGE: Table 1.

2011 ◽  
Vol 20 (9) ◽  
pp. 1979-1981 ◽  
Author(s):  
Kevin M. Waters ◽  
Lynne R. Wilkens ◽  
Kristine R. Monroe ◽  
Daniel O. Stram ◽  
Laurence N. Kolonel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Type 2 Diabetes ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Diabetes Risk ◽  
Risk Variants ◽  
Multiethnic Cohort ◽  
Page Table

scholarly journals The ATP-Sensitive K+ Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity

Diabetes ◽  
2011 ◽  
Vol 61 (1) ◽  
pp. 241-249 ◽  
Author(s):  
M. Fatehi ◽  
M. Raja ◽  
C. Carter ◽  
D. Soliman ◽  
A. Holt ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Risk ◽  
K Channel ◽  
Risk Variant ◽  
Mgatpase Activity

scholarly journals A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

2018 ◽  
Vol 102 (4) ◽  
pp. 620-635 ◽  
Author(s):  
Ina Kycia ◽  
Brooke N. Wolford ◽  
Jeroen R. Huyghe ◽  
Christian Fuchsberger ◽  
Swarooparani Vadlamudi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Common Type ◽  
Diabetes Risk ◽  
Risk Variant ◽  
Evolutionarily Conserved

scholarly journals Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans

Metabolism ◽  
2015 ◽  
Vol 64 (12) ◽  
pp. 1650-1657 ◽  
Author(s):  
Marta Garaulet ◽  
Purificación Gómez-Abellán ◽  
Patricia Rubio-Sastre ◽  
Juan A. Madrid ◽  
Richa Saxena ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Deleterious Effect ◽  
Common Type ◽  
Diabetes Risk ◽  
Risk Variant

scholarly journals Genetic risk, adherence to a healthy lifestyle, and type 2 diabetes risk among 550,000 Chinese adults: results from 2 independent Asian cohorts

2020 ◽  
Vol 111 (3) ◽  
pp. 698-707 ◽  
Author(s):  
Haoxin Li ◽  
Chiea-Chuen Khor ◽  
Junning Fan ◽  
Jun Lv ◽  
Canqing Yu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Risk ◽  
Lower Risk ◽  
Healthy Lifestyle ◽  
Genetic Risk Score ◽  
Lifestyle Factors ◽  
Diabetes Risk ◽  
Unhealthy Lifestyle ◽  
High Genetic Risk

ABSTRACT Background Whether genetic susceptibility to type 2 diabetes is modified by a healthy lifestyle among Chinese remains unknown. Objectives The aim of the study was to determine whether genetic risk and adherence to a healthy lifestyle contribute independently to the risk of developing type 2 diabetes. Methods We defined a lifestyle score using BMI, alcohol intake, smoking, physical activities, and diets in 461,030 participants from the China Kadoorie Biobank and 38,434 participants from the Singapore Chinese Health Study. A genetic risk score was constructed based on type 2 diabetes loci among 100,175 and 16,172 participants in each cohort, respectively. A Cox proportional-hazards model was used to estimate the interaction between genetic and lifestyle factors on the risk of type 2 diabetes. Results In 2 independent Asian cohorts, we consistently found a healthy lifestyle (the bottom quintile of lifestyle score) was associated with a substantially lower risk of type 2 diabetes than an unhealthy lifestyle (the top quintile of lifestyle score) regardless of genetic risk. In those at a high genetic risk, the risk of type 2 diabetes was 57% lower among participants with a healthy lifestyle than among those with an unhealthy lifestyle in the pooled cohorts. Among participants at high genetic risk, the standardized 10-y incidence of type 2 diabetes was 7.11% in those with an unhealthy lifestyle vs. 2.45% in those with a healthy lifestyle. Conclusions In 2 independent cohorts involving 558,302 Chinese participants, we did not observe an interaction between genetics and lifestyle with type 2 diabetes risk, but our findings provide replicable evidence to show lifestyle factors and genetic factors were independently associated with the risk of type 2 diabetes. Within any genetic risk category, a healthy lifestyle was associated with a significantly lower risk of type 2 diabetes among the Chinese population.

Smoking Tied to Greater Type 2 Diabetes Risk

2008 ◽  
Vol 38 (1) ◽  
pp. 14-15
Author(s):  
MARY ANN MOON
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Risk

Hormonal factors and type 2 diabetes risk in women: a 22 year follow-up study on more than 83 000 women from the E3N cohort study

2019 ◽  
Author(s):  
Sopio Tatulashvili ◽  
Gaelle Gusto ◽  
Beverley Balkau ◽  
Emmanuel Cosson ◽  
Fabrice Bonnet ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Diabetes Risk ◽  
Hormonal Factors ◽  
Follow Up Study

1532-P: Greater Type 2 Diabetes Risk among College Students in Egypt Is Alarming

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1532-P
Author(s):  
ELSAYED MOHAMED EID ◽  
SHAHEEN TOMAH ◽  
AHMED H. ELDIB ◽  
MEGAHED MOH ABOUELMAGD ◽  
EMAN M. FAHMY ◽  
...  
Keyword(s):  
College Students ◽  
Type 2 Diabetes ◽  
Diabetes Risk
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