Near‐infrared fluorescence imaging of gastrin releasing peptide receptor targeting in prostate cancer lymph node metastases

The Prostate ◽  
2012 ◽  
Vol 73 (8) ◽  
pp. 842-854 ◽  
Author(s):  
Quan‐Yu Cai ◽  
Ping Yu ◽  
Cynthia Besch‐Williford ◽  
Charles J. Smith ◽  
Gary L. Sieckman ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Fluorescence Imaging ◽  
Lymph Node Metastases ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide ◽  
Node Metastases ◽  
Near Infrared Fluorescence Imaging

Intraoperative identification of sentinel lymph node guided by near-infrared fluorescence imaging for breast cancer patients

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 615-615 ◽  
Author(s):  
N. Tagaya
Keyword(s):  
Lymph Node ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
False Negative ◽  
Breast Cancer Patients ◽  
Navigation Surgery ◽  
Near Infrared Fluorescence ◽  
Vital Dye ◽  
High Detection ◽  
Near Infrared Fluorescence Imaging

615 Background: Recently, radioactive tracer, a vital dye, or a combination of both has been applied intraoperatively to detect sentinel lymph nodes (SLN) for patients with early breast cancers. We present a novel method of SLN identification using near-infrared fluorescence imaging that provides with high detection and low false-negative rates. Materials and Methods: This study enrolled 52 patients with a tumor less than 3 cm in diameter. Their mean age was 54.7 years. Preoperative TNM stage was I in 35 cases, IIa in 12, and IIb in 5, respectively. Initially the combination dye of indocyanine green and indigocarmine was injected subdermally in the areola. Fluorescence imaging (photodynamic eye: Hamamatsu Photonics Co.) was obtained using a charge coupled device camera with a cut filter as the detector, and light emitting diodes at 760 nm as the light source. Subcutaneous lymphatic channels draining from the areola to the axilla or other directions were visible by fluorescence imagings immediately. After incising the axillary skin 1 cm cranial side from the disappeared point of fluorescence image, SLN was then dissected under the guidance of fluorescence. Results: In all but one patient, lymphatic channels and SLN were successfully visualized (identification rate: 98.1%). SLN was observed before skin incision in two patients. The number of fluorescence SLN ranged from 0 to 11 (mean: 4.7) and blue dyed SLN ranged from o to 6 (mean: 2.0). SLN was not identified in one patient in the former and 7 patients in the latter. Twelve patients had lymph node metastases pathologically. All of them were recognized by fluorescence imaging, however, three patients with metastatic LN were not identified by a vital dye. Conclusions: This method is feasible and safe to detect SLN intraoperatively with less invasive, real-time observation and no requirement of training. We are convinced that this method will provide with high detection and low false-negative rates in SLN navigation surgery. No significant financial relationships to disclose.

scholarly journals Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging

2014 ◽  
Vol 110 (7) ◽  
pp. 845-850 ◽  
Author(s):  
B.E. Schaafsma ◽  
F.P.R. Verbeek ◽  
H.W. Elzevier ◽  
Q.R.J.G. Tummers ◽  
J.R. van der Vorst ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Near Infrared Fluorescence ◽  
Lymph Node Mapping ◽  
Near Infrared Fluorescence Imaging

scholarly journals Near-infrared fluorescence imaging of prostate cancer using heptamethine carbocyanine dyes

2014 ◽  
Vol 11 (2) ◽  
pp. 821-828 ◽  
Author(s):  
JIANLIN YUAN ◽  
XIAOMIN YI ◽  
FEI YAN ◽  
FULI WANG ◽  
WEIJUN QIN ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Carbocyanine Dyes ◽  
Near Infrared Fluorescence Imaging
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