Knockdown of scavenger receptor Class B Type I reduces prostate specific antigen secretion and viability of prostate cancer cells

The Prostate ◽  
2011 ◽  
Vol 72 (9) ◽  
pp. 955-965 ◽  
Author(s):  
Alexis L. Twiddy ◽  
Michael E. Cox ◽  
Kishor M. Wasan
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Specific Antigen ◽  
Scavenger Receptor ◽  
Specific Antigen ◽  
Type I ◽  
Prostate Cancer Cells ◽  
Scavenger Receptor Class ◽  
Class B

scholarly journals Uptake of high-density lipoprotein by scavenger receptor class B type 1 is associated with prostate cancer proliferation and tumor progression in mice

2020 ◽  
Vol 295 (24) ◽  
pp. 8252-8261 ◽  
Author(s):  
C. Alicia Traughber ◽  
Emmanuel Opoku ◽  
Gregory Brubaker ◽  
Jennifer Major ◽  
Hanxu Lu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cell ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Prostate Cancer Cells ◽  
Scavenger Receptor Class ◽  
Class B

High-density lipoprotein (HDL) metabolism is facilitated in part by scavenger receptor class B, type 1 (SR-B1) that mediates HDL uptake into cells. Higher levels of HDL have been associated with protection in other diseases, however, its role in prostate cancer is not definitive. SR-B1 is up-regulated in prostate cancer tissue, suggesting a possible role of this receptor in tumor progression. Here, we report that knockout (KO) of SR-B1 in both human and mouse prostate cancer cell lines through CRISPR/Cas9-mediated genome editing reduces HDL uptake into the prostate cancer cells and reduces their proliferation in response to HDL. In vivo studies using syngeneic SR-B1 WT (SR-B1+/+) and SR-B1 KO (SR-B1−/−) prostate cancer cells in WT and apolipoprotein-AI KO (apoA1-KO) C57BL/6J mice revealed that WT hosts, containing higher levels of total and HDL-cholesterol, grew larger tumors than apoA1-KO hosts with lower levels of total and HDL-cholesterol. Furthermore, SR-B1−/− prostate cancer cells formed smaller tumors in WT hosts than SR-B1+/+ cells in the same host model. Increased tumor volume was overall associated with reduced survival. We conclude that knocking out SR-B1 in prostate cancer tumors reduces HDL-associated increases in prostate cancer cell proliferation and disease progression.

scholarly journals miR-183 in Prostate Cancer Cells Positively Regulates Synthesis and Serum Levels of Prostate-specific Antigen

2015 ◽  
Vol 68 (4) ◽  
pp. 581-588 ◽  
Author(s):  
Olivia Larne ◽  
Päivi Östling ◽  
Benedikta S. Haflidadóttir ◽  
Zandra Hagman ◽  
Anna Aakula ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Serum Levels ◽  
Prostate Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document