TM4SF1 , a novel primary androgen receptor target gene over-expressed in human prostate cancer and involved in cell migration

The Prostate ◽  
2011 ◽  
Vol 71 (11) ◽  
pp. 1239-1250 ◽  
Author(s):  
Nathalie Allioli ◽  
Séverine Vincent ◽  
Virginie Vlaeminck-Guillem ◽  
Myriam Decaussin-Petrucci ◽  
Florence Ragage ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Androgen Receptor ◽  
Target Gene ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Androgen Receptor Target Gene

scholarly journals GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Eugine Lee ◽  
John Wongvipat ◽  
Danielle Choi ◽  
Ping Wang ◽  
Young Sun Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Target Gene ◽  
Prostate Cancer Cell ◽  
Human Prostate ◽  
Genomic Alteration ◽  
Human Prostate Cancer ◽  
Genomic Amplification ◽  
Human Prostate Cancer Cell

Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here, we show that the magnitude of AR signaling output, independent of AR genomic alteration or expression level, also contributes to antiandrogen resistance, through upregulation of the coactivator GREB1. We demonstrate 100-fold heterogeneity in AR output within human prostate cancer cell lines and show that cells with high AR output have reduced sensitivity to enzalutamide. Through transcriptomic and shRNA knockdown studies, together with analysis of clinical datasets, we identify GREB1 as a gene responsible for high AR output. We show that GREB1 is an AR target gene that amplifies AR output by enhancing AR DNA binding and promoting EP300 recruitment. GREB1 knockdown in high AR output cells restores enzalutamide sensitivity in vivo. Thus, GREB1 is a candidate driver of enzalutamide resistance through a novel feed forward mechanism.

Anti-androgen receptor activity of apoptotic CK2 inhibitor CX4945 in human prostate cancer LNCap cells

2012 ◽  
Vol 22 (17) ◽  
pp. 5470-5474 ◽  
Author(s):  
Byung Jun Ryu ◽  
Seung-hwa Baek ◽  
Jiyeon Kim ◽  
Su Jung Bae ◽  
Sung-Youn Chang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Activity ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Lncap Cells ◽  
Androgen Receptor Activity ◽  
Ck2 Inhibitor

scholarly journals The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells

The Prostate ◽  
2011 ◽  
Vol 72 (6) ◽  
pp. 612-625 ◽  
Author(s):  
Alexandra M. Fajardo ◽  
Debra A. MacKenzie ◽  
Ming Ji ◽  
Lorraine M. Deck ◽  
David L. Vander Jagt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Curcumin Analog

Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells

2010 ◽  
Vol 297 (2) ◽  
pp. 226-230 ◽  
Author(s):  
Itsuhiro Takizawa ◽  
Tsutomu Nishiyama ◽  
Noboru Hara ◽  
Tatsuhiko Hoshii ◽  
Fumio Ishizaki ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Hydroxysteroid Dehydrogenase ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Agonistic Activity
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