Ubiquitous mitochondrial creatine kinase is overexpressed in the conditioned medium and the extract of LNCaP lineaged androgen independent cell lines and facilitates prostate cancer progression

The Prostate ◽  
2009 ◽  
Vol 69 (11) ◽  
pp. 1176-1187 ◽  
Author(s):  
Bo Pang ◽  
Hui Zhang ◽  
Jian Wang ◽  
Wen-Zheng Chen ◽  
Shan-Hu Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Creatine Kinase ◽  
Conditioned Medium ◽  
Cell Lines ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Mitochondrial Creatine Kinase ◽  
Androgen Independent

scholarly journals The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression

2016 ◽  
Vol 7 (1) ◽  
pp. 50-59 ◽  
Author(s):  
Rie Amamoto ◽  
Takeshi Uchiumi ◽  
Mikako Yagi ◽  
Keisuke Monji ◽  
YooHyun Song ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Creatine Kinase ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Mitochondrial Creatine Kinase

463: Telomerase Inhibition Prevents Androgen Independent Osseous Prostate Cancer Progression

2005 ◽  
Vol 173 (4S) ◽  
pp. 126-127
Author(s):  
Yingming Li ◽  
Melissa Thompson ◽  
Zhu Chen ◽  
Bahaa S. Malaeb ◽  
David Corey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Telomerase Inhibition ◽  
Androgen Independent

scholarly journals Modeling human prostate cancer progression in vitro

2018 ◽  
Vol 40 (7) ◽  
pp. 893-902 ◽  
Author(s):  
Teresa T Liu ◽  
Jonathan A Ewald ◽  
Emily A Ricke ◽  
Robert Bell ◽  
Colin Collins ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Progression ◽  
Human Prostate ◽  
Molecular Characteristics ◽  
Prostate Cancer Progression ◽  
Altered Gene Expression ◽  
Unique Model ◽  
Altered Gene

Abstract Detailed mechanisms involved in prostate cancer (CaP) development and progression are not well understood. Current experimental models used to study CaP are not well suited to address this issue. Previously, we have described the hormonal progression of non-tumorigenic human prostate epithelial cells (BPH1) into malignant cells via tissue recombination. Here, we describe a method to derive human cell lines from distinct stages of CaP that parallel cellular, genetic and epigenetic changes found in patients with cancers. This BPH1-derived Cancer Progression (BCaP) model represents different stages of cancer. Using diverse analytical strategies, we show that the BCaP model reproduces molecular characteristics of CaP in human patients. Furthermore, we demonstrate that BCaP cells have altered gene expression of shared pathways with human and transgenic mouse CaP data, as well as, increasing genomic instability with TMPRSS2–ERG fusion in advanced tumor cells. Together, these cell lines represent a unique model of human CaP progression providing a novel tool that will allow the discovery and experimental validation of mechanisms regulating human CaP development and progression. This BPH1-derived Cancer Progression (BCaP) model represents different stages of cancer. The BCaP model reproduces molecular characteristics of prostate cancer. The cells have altered gene expression with TMPRSS2-ERG fusion representing a unique model for prostate cancer progression.

SELDI protein profiling of dunning R-3327 derived cell lines: Identification of molecular markers of prostate cancer progression

The Prostate ◽  
2007 ◽  
Vol 67 (14) ◽  
pp. 1565-1575 ◽  
Author(s):  
Gunjan Malik ◽  
Elizabeth Rojahn ◽  
Michael D. Ward ◽  
Mathew B. Gretzer ◽  
Alan W. Partin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Markers ◽  
Cell Lines ◽  
Cancer Progression ◽  
Protein Profiling ◽  
Prostate Cancer Progression
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