Relaxin becomes upregulated during prostate cancer progression to androgen independence and is negatively regulated by androgens

The Prostate ◽  
2006 ◽  
Vol 66 (16) ◽  
pp. 1698-1709 ◽  
Author(s):  
Vanessa C. Thompson ◽  
Tanis G.W. Morris ◽  
Dawn R. Cochrane ◽  
John Cavanagh ◽  
Latif A. Wafa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Androgen Independence

CSL regulates AKT to mediate androgen independence in prostate cancer progression

The Prostate ◽  
2015 ◽  
Vol 76 (2) ◽  
pp. 140-150 ◽  
Author(s):  
Huiyan Wang ◽  
Lixia Zhang ◽  
Ying Fu ◽  
Fang Fang ◽  
Yong Jiang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Androgen Independence

LuCaP 35: A new model of prostate cancer progression to androgen independence

The Prostate ◽  
2003 ◽  
Vol 55 (4) ◽  
pp. 239-246 ◽  
Author(s):  
Eva Corey ◽  
Janna E. Quinn ◽  
Kent R. Buhler ◽  
Peter S. Nelson ◽  
Jill A. Macoska ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Androgen Independence ◽  
New Model

scholarly journals Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression

Cell Research ◽  
2019 ◽  
Vol 29 (9) ◽  
pp. 773-775 ◽  
Author(s):  
Bohan Xu ◽  
Bing Song ◽  
Xiaodong Lu ◽  
Jung Kim ◽  
Ming Hu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Androgen Independence

Emergence of Androgen Independence at Early Stages of Prostate Cancer Progression in Nkx3.1; Pten Mice

2006 ◽  
Vol 66 (16) ◽  
pp. 7929-7933 ◽  
Author(s):  
Hui Gao ◽  
Xuesong Ouyang ◽  
Whitney A. Banach-Petrosky ◽  
Michael M. Shen ◽  
Cory Abate-Shen
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Androgen Independence ◽  
Early Stages

Signal transduction in prostate cancer progression

2005 ◽  
Vol 108 (4) ◽  
pp. 293-308 ◽  
Author(s):  
Daniel GIOELI
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Late Stage ◽  
The United States ◽  
High Rate ◽  
Prostate Cancer Progression ◽  
Cancer Cell Growth ◽  
Androgen Independence ◽  
Growth Factor Signalling ◽  
Androgen Independent

Prostate cancer is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths in the United States. When prostate cancer initially presents in the clinic, the tumour is dependent on androgen for growth and, therefore, responsive to the surgical or pharmacological ablation of circulating androgens. However, there is a high rate of treatment failure because the disease often recurs as androgen-independent metastases. Surprisingly, this late-stage androgen-independent prostate cancer almost always retains expression of the AR (androgen receptor), despite the near absence of circulating androgens. Although late-stage prostate cancer is androgen-independent, the AR still seems to play a role in cancer cell growth at this stage of disease. Therefore a key to understanding hormone-independent prostate cancer is to determine the mechanism(s) by which the AR can function even in the absence of physiological levels of circulating androgen. This review will focus on the role of growth factor signalling in prostate cancer progression to androgen independence and thus outline potential molecular areas of intervention to treat prostate cancer progression.

463: Telomerase Inhibition Prevents Androgen Independent Osseous Prostate Cancer Progression

2005 ◽  
Vol 173 (4S) ◽  
pp. 126-127
Author(s):  
Yingming Li ◽  
Melissa Thompson ◽  
Zhu Chen ◽  
Bahaa S. Malaeb ◽  
David Corey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Telomerase Inhibition ◽  
Androgen Independent

479: Prostate-Specific Membrane Antigen (PSMA) Expression as a Predictor of Prostate Cancer Progression

2006 ◽  
Vol 175 (4S) ◽  
pp. 155-156
Author(s):  
Matthias D. Hofer ◽  
Sven Perner ◽  
Haojie Li ◽  
Rainer Kuefer ◽  
Richard E. Hautmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Progression ◽  
Specific Membrane ◽  
Psma Expression
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