Expression of mTOR signaling pathway markers in prostate cancer progression

The Prostate ◽  
2006 ◽  
Vol 66 (11) ◽  
pp. 1203-1212 ◽  
Author(s):  
Celeste L. Kremer ◽  
Rob R. Klein ◽  
Jenny Mendelson ◽  
Walden Browne ◽  
Linda K. Samadzedeh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Mtor Signaling ◽  
Prostate Cancer Progression ◽  
Mtor Signaling Pathway

scholarly journals SU6668 modulates prostate cancer progression by downregulating MTDH/AKT signaling pathway

2017 ◽  
Vol 50 (5) ◽  
pp. 1601-1611 ◽  
Author(s):  
Benjiang Qian ◽  
Yi Yao ◽  
Changming Liu ◽  
Jiabing Zhang ◽  
Huihong Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Akt Signaling ◽  
Prostate Cancer Progression ◽  
Akt Signaling Pathway

scholarly journals Inhibition of Prostate Cancer DU-145 Cells Proliferation by Anthopleura anjunae Oligopeptide (YVPGP) via PI3K/AKT/mTOR Signaling Pathway

Marine Drugs ◽  
2018 ◽  
Vol 16 (9) ◽  
pp. 325 ◽  
Author(s):  
Xiaojuan Li ◽  
Yunping Tang ◽  
Fangmiao Yu ◽  
Yu Sun ◽  
Fangfang Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Caspase 3 ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Nude Mouse Model ◽  
Dose Dependent

We investigated the antitumor mechanism of Anthopleura anjunae oligopeptide (AAP-H, YVPGP) in prostate cancer DU-145 cells in vitro and in vivo. Results indicated that AAP-H was nontoxic and exhibited antitumor activities. Cell cycle analysis indicated that AAP-H may arrest DU-145 cells in the S phase. The role of the phosphatidylinositol 3-kinase/protein kinase B/mammalian rapamycin target protein (PI3K/AKT/mTOR) signaling pathway in the antitumor mechanism of APP-H was investigated. Results showed that AAP-H treatment led to dose-dependent reduction in the levels of p-AKT (Ser473), p-PI3K (p85), and p-mTOR (Ser2448), whereas t-AKT and t-PI3K levels remained unaltered compared to the untreated DU-145 cells. Inhibition of PI3K/AKT/mTOR signaling pathway in the DU-145 cells by employing inhibitor LY294002 (10 μM) or rapamycin (20 nM) effectively attenuated AAP-H-induced phosphorylation of AKT and mTOR. At the same time, inhibitor addition further elevated AAP-H-induced cleaved-caspase-3 levels. Furthermore, the effect of AAP-H on tumor growth and the role of the PI3K/AKT/mTOR signaling pathway in nude mouse model were also investigated. Immunohistochemical analysis showed that activated AKT, PI3K, and mTOR levels were reduced in DU-145 xenografts. Western blotting showed that AAP-H treatment resulted in dose-dependent reduction in p-AKT (Ser473), p-PI3K (p85), and p-mTOR (Ser2448) levels, whereas t-AKT and t-PI3K levels remained unaltered. Similarly, Bcl-xL levels decreased, whereas that of Bax increased after AAP-H treatment. AAP-H also increased initiator (caspase 8 and 9) and executor caspase (caspase 3 and 7) levels. Therefore, the antitumor mechanism of APP-H on DU-145 cells may involve regulation of the PI3K/AKT/mTOR signaling pathway, which eventually promotes apoptosis via mitochondrial and death receptor pathways. Thus, the hydrophobic oligopeptide (YVPGP) can be developed as an adjuvant for the prevention or treatment of prostate cancer in the future.

MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway

2021 ◽  
Author(s):  
Thanigaivelan Kanagasabai ◽  
Guoliang Li ◽  
Tian Huai Shen ◽  
Nataliya Gladoun ◽  
Mireia Castillo-Martin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Prostate Cancer Progression

CIP2A mediates prostate cancer progression via the c-MYC signaling pathway

Tumor Biology ◽  
2015 ◽  
Vol 36 (5) ◽  
pp. 3583-3589 ◽  
Author(s):  
Zexiong Guo ◽  
Dehao Liu ◽  
Zexuan Su
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Prostate Cancer Progression

Overexpression of LINC00037 represses cervical cancer progression by activating mTOR signaling pathway

2019 ◽  
Vol 234 (8) ◽  
pp. 13353-13360
Author(s):  
Li‐Yun Yuan ◽  
Xiaomin Qin ◽  
Lin Li ◽  
Jinting Zhou ◽  
Min Zhou ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway
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