In vitro cytotoxic effects of imatinib in combination with anticancer drugs in human prostate cancer cell lines

The Prostate ◽  
2004 ◽  
Vol 63 (4) ◽  
pp. 385-394 ◽  
Author(s):  
Hubert R. Kübler ◽  
Heiner van Randenborgh ◽  
Uwe Treiber ◽  
Sebastian Wutzler ◽  
Carolus Battistel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Anticancer Drugs ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Cytotoxic Effects ◽  
Prostate Cancer Cell Lines

250: In Vitro Cytotoxic Effects of Imatinib in Combination with Anticancer Drugs in Human Prostate Cancer Cell Lines

2005 ◽  
Vol 173 (4S) ◽  
pp. 68-69
Author(s):  
Hubert Kübler ◽  
Heiner van Randenborgh ◽  
Uwe Treiber ◽  
Sebastian Wutzler ◽  
Antonie Lehmer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Anticancer Drugs ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Cytotoxic Effects ◽  
Prostate Cancer Cell Lines

Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways

Planta Medica ◽  
2020 ◽  
Vol 86 (18) ◽  
pp. 1401-1410
Author(s):  
Qi Zeng ◽  
Yun Zeng ◽  
Yonghua Zhan ◽  
Xu Nie ◽  
Yingying Guo
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Inhibitory Activity ◽  
Prostate Cancer Cell ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines

AbstractBritanin, a natural pseudoguaiacane sesquiterpene lactone, has significant antioxidant and anti-inflammatory activity, but little is known about its tumor inhibitory activity and the underlying mechanism. Here, we demonstrated in vitro and in vivo that britanin inhibited the growth of human prostate cancer cell lines (PC-3, PC-3-LUC, and DU-145). Through in vitro study, the results showed that britanin significantly decreased cell proliferation, migration, and motility. The moderate toxicity of britanin was determined with an acute toxicity study. A luciferase-labeled animal tumor xenograft model and bioluminescence imaging were applied, combining with biological validation for assessing the tumor progression. In vivo results demonstrated that britanin inhibited the growth of PC-3-LUC. The interleukin-2 level in mice was upregulated by britanin, which indicated that britanin induced antitumor immune activation. In addition, britanin downregulated the expression of nuclear factor (NF)-κB p105/p50, pp65, IκBα, pIκBα, phosphoinositide 3-kinase, pPI3k, Akt (protein kinase B, PKB), and pAkt proteins and upregulated expression of Bax. We discovered that britanin inhibits the growth of prostate cancer cells both in vitro and in vivo by regulating PI3K/Akt/NF-κB-related proteins and activating immunity. These findings shed light on the development of britanin as a promising agent for prostate cancer therapy.

Antitumor effects of etodolac, a selective cyclooxygenase-II inhibitor, against human prostate cancer cell lines in vitro and in vivo

Urology ◽  
2005 ◽  
Vol 66 (6) ◽  
pp. 1239-1244 ◽  
Author(s):  
Katsumi Shigemura ◽  
Toshiro Shirakawa ◽  
Yoshitaka Wada ◽  
Sadao Kamidono ◽  
Masato Fujisawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Human Prostate Cancer ◽  
Antitumor Effects ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines

Elevated Transferrin Receptor Content in Human Prostate Cancer Cell Lines Assessed in Vitro and in Vivo

1990 ◽  
Vol 143 (2) ◽  
pp. 381-385 ◽  
Author(s):  
Harold N. Keer ◽  
James M. Kozlowski ◽  
Yvonne C. Tsai ◽  
Chung Lee ◽  
Robert N. McEwan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Transferrin Receptor ◽  
Prostate Cancer Cell ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines
Sign in / Sign up

Export Citation Format

Share Document