Increased expression of bone morphogenetic protein-7 in bone metastatic prostate cancer

The Prostate ◽  
2003 ◽  
Vol 54 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Hiroshi Masuda ◽  
Yoshitatsu Fukabori ◽  
Katsuya Nakano ◽  
Yutaka Takezawa ◽  
Takanori cSuzuki ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Morphogenetic Protein ◽  
Metastatic Prostate Cancer ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein

Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

2011 ◽  
Vol 195 (6) ◽  
pp. i8-i8
Author(s):  
Aya Kobayashi ◽  
Hiroshi Okuda ◽  
Fei Xing ◽  
Puspa R. Pandey ◽  
Misako Watabe ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein

scholarly journals Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

2012 ◽  
Vol 209 (3) ◽  
pp. 639-639 ◽  
Author(s):  
Aya Kobayashi ◽  
Hiroshi Okuda ◽  
Fei Xing ◽  
Puspa R. Pandey ◽  
Misako Watabe ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein

scholarly journals Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

2011 ◽  
Vol 208 (13) ◽  
pp. 2641-2655 ◽  
Author(s):  
Aya Kobayashi ◽  
Hiroshi Okuda ◽  
Fei Xing ◽  
Puspa R. Pandey ◽  
Misako Watabe ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Morphogenetic Protein ◽  
Metastatic Disease ◽  
Critical Role ◽  
Metastatic Tumor ◽  
Critical Issue ◽  
Mitogen Activated Protein Kinase ◽  
Metastasis Suppressor ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein

Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant organs are a critical issue. However, how metastatic tumor cells become dormant and how and why tumors recur in target organs are not well understood. In this study, we demonstrate that BMP7 (bone morphogenetic protein 7) secreted from bone stromal cells induces senescence in prostate cancer stem-like cells (CSCs) by activating p38 mitogen-activated protein kinase and increasing expression of the cell cycle inhibitor, p21, and the metastasis suppressor gene, NDRG1 (N-myc downstream-regulated gene 1). This effect of BMP7 depended on BMPR2 (BMP receptor 2), and BMPR2 expression inversely correlated with recurrence and bone metastasis in prostate cancer patients. Importantly, this BMP7-induced senescence in CSCs was reversible upon withdrawal of BMP7. Furthermore, treatment of mice with BMP7 significantly suppressed the growth of CSCs in bone, whereas the withdrawal of BMP7 restarted growth of these cells. These results suggest that the BMP7–BMPR2–p38–NDRG1 axis plays a critical role in dormancy and recurrence of prostate CSCs in bone and suggest a potential therapeutic utility of BMP7 for recurrent metastatic disease.

Bone morphogenetic protein-7 (BMP-7) is downregulated in prostate cancer

2003 ◽  
Vol 2 (6) ◽  
pp. 87
Author(s):  
Cyrill A Rentsch ◽  
Ruth Schwaninger ◽  
Antoinette Wetterwald ◽  
Regula Markwalder ◽  
Irena Klima ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein
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