In vivo expression and function of the sodium iodide symporter following gene transfer in the MATLyLu rat model of metastatic prostate cancer

The Prostate ◽  
2002 ◽  
Vol 50 (3) ◽  
pp. 170-178 ◽  
Author(s):  
Krista M.D. La Perle ◽  
Daniel Shen ◽  
Tara L.F. Buckwalter ◽  
Bonnie Williams ◽  
Aaron Haynam ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Transfer ◽  
Rat Model ◽  
Metastatic Prostate Cancer ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter ◽  
In Vivo Expression ◽  
And Function

scholarly journals In vivo sodium iodide symporter gene therapy of prostate cancer

Gene Therapy ◽  
2001 ◽  
Vol 8 (20) ◽  
pp. 1524-1531 ◽  
Author(s):  
C Spitzweg ◽  
AB Dietz ◽  
MK O'Connor ◽  
ER Bergert ◽  
DJ Tindall ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter

scholarly journals Forskolin, 8-Br-3′,5′-Cyclic Adenosine 5′-Monophosphate, and Catalytic Protein Kinase A Expression in the Nucleus Increase Radioiodide Uptake and Sodium/Iodide Symporter Protein Levels in RET/PTC1-Expressing Cells

2004 ◽  
Vol 89 (12) ◽  
pp. 6168-6172 ◽  
Author(s):  
Anjli Venkateswaran ◽  
Derek K. Marsee ◽  
Steven H. Green ◽  
Sissy M. Jhiang
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter ◽  
Thyroid Cells ◽  
Protein Levels ◽  
And Function ◽  
Kinase A

Abstract RET/PTC1, a thyroid-specific oncogene, has been reported to down-regulate sodium/iodide symporter (NIS) expression and function in vitro and in vivo. Recently, RET/PTC1 has been shown to interfere with TSH signaling at multiple levels in thyroid cells. The objective of this study was to investigate whether RET/PTC1-mediated NIS reduction can be rescued by activating cAMP-protein kinase A (PKA) pathways. We showed that both forskolin and 8-Br-cAMP increase radioiodide uptake and NIS protein in RET/PTC1-expressing cells to the same extent as the parental PC Cl 3 cells. We found that RET/PTC1 decreases nuclear localization of catalytic PKA, and forskolin treatment was able to counteract this RET/PTC1 effect. Furthermore, transient expression of catalytic PKA in the nucleus increased radioiodide uptake and NIS protein in RET/PTC1-expressing cells. Taken together, these studies suggest that RET/PTC1 down-regulates NIS expression by interrupting TSH/cAMP signaling, and this RET/PTC1 effect can be reversed by activating cAMP-PKA pathways.

scholarly journals Prolonged Cardiac Allograft Survival Using Iodine 131 After Human Sodium Iodide Symporter Gene Transfer in A Rat Model

2010 ◽  
Vol 42 (5) ◽  
pp. 1888-1894 ◽  
Author(s):  
D. Ricci ◽  
A.A. Mennander ◽  
N. Miyagi ◽  
V.P. Rao ◽  
H.D. Tazelaar ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Rat Model ◽  
Sodium Iodide ◽  
Cardiac Allograft ◽  
Sodium Iodide Symporter ◽  
Allograft Survival ◽  
Iodine 131

scholarly journals In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomas

Gene Therapy ◽  
2002 ◽  
Vol 9 (17) ◽  
pp. 1139-1145 ◽  
Author(s):  
J-Y Cho ◽  
D HY Shen ◽  
W Yang ◽  
B Williams ◽  
T LF Buckwalter ◽  
...  
Keyword(s):  
Animal Model ◽  
Gene Transfer ◽  
In Vivo Imaging ◽  
Sodium Iodide ◽  
Radioiodine Therapy ◽  
Sodium Iodide Symporter
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