scholarly journals Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2

2009 ◽  
Vol 18 (3) ◽  
pp. 657-661 ◽  
Author(s):  
Bernhard C. Lechtenberg ◽  
Mark D. Allen ◽  
Trevor J. Rutherford ◽  
Stefan M. V. Freund ◽  
Mark Bycroft
Keyword(s):  
Zinc Finger ◽  
Solution Structure ◽  
Polycomb Group ◽  
Zinc Finger Domain ◽  
Polycomb Group Protein ◽  
Protein L ◽  
Group Protein

PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene

2019 ◽  
Vol 509 (2) ◽  
pp. 469-475 ◽  
Author(s):  
Pinakin Pandya ◽  
Ronit Pasvolsky ◽  
Yael Babichev ◽  
Alex Braiman ◽  
Stephan Witte ◽  
...  
Keyword(s):  
Target Gene ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
H3k27 Methylation ◽  
Group Protein

scholarly journals Enhancer of Zeste Homolog 2 Overexpression Has a Role in the Development of Anaplastic Thyroid Carcinomas

2011 ◽  
Vol 96 (4) ◽  
pp. 1029-1038 ◽  
Author(s):  
Eleonora Borbone ◽  
Giancarlo Troncone ◽  
Angelo Ferraro ◽  
Zuzana Jasencakova ◽  
Lovorka Stojic ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Anaplastic Thyroid Carcinoma ◽  
Polycomb Group ◽  
Migration And Invasion ◽  
Polycomb Group Protein ◽  
Expression Levels ◽  
Thyroid Carcinomas ◽  
Enhancer Of Zeste ◽  
Pax8 Gene ◽  
Group Protein

Abstract Context: Enhancer of zeste homolog 2 (EZH2) is a histone lysine methyltransferase belonging to the polycomb group protein family. Overexpression of EZH2 has been found in several human malignancies including hematological and solid tumors. Objectives: In this study we investigated the expression levels of EZH2 and its polycomb group protein partners in thyroid carcinoma tissues with different degrees of malignancy to identify potential new therapeutic targets for anaplastic thyroid carcinoma (ATC). Results: We show that high EZH2 expression levels are characteristic of undifferentiated ATC, whereas no significant changes were observed in well-differentiated papillary and follicular thyroid carcinomas as compared with normal thyroid. Knockdown of EZH2 in ATC cell lines results in cell growth inhibition, loss of anchorage-independent growth, migration, and invasion properties. Moreover, we demonstrate that EZH2 directly controls differentiation of ATC cells by silencing the thyroid specific transcription factor paired-box gene 8 (PAX8). Conclusions: EZH2 is specifically overexpressed in ATC, and it directly contributes to transcriptional silencing of PAX8 gene and ATC differentiation.

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