scholarly journals DISOselect: Disorder predictor selection at the protein level

2019 ◽  
Vol 29 (1) ◽  
pp. 184-200 ◽  
Author(s):  
Akila Katuwawala ◽  
Christopher J. Oldfield ◽  
Lukasz Kurgan
Keyword(s):  
Protein Level ◽  
Disorder Predictor

No Association Between lck Gene Polymorphisms and Protein Level in Type 1 Diabetes

Diabetes ◽  
2002 ◽  
Vol 51 (11) ◽  
pp. 3326-3330 ◽  
Author(s):  
S. Nervi ◽  
S. Nicodeme ◽  
C. Gartioux ◽  
C. Atlan ◽  
M. Lathrop ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Protein Level ◽  
Gene Polymorphisms

Pengaruh Lama Pengasinan Terhadap Kadar Protein Putih Telur Itik

2014 ◽  
Vol 1 (1) ◽  
pp. 36 ◽  
Author(s):  
Siti Fatimah ◽  
Muji Rahayu ◽  
Siti Aminah
Keyword(s):  
Protein Level ◽  
Egg White ◽  
Special Treatment ◽  
Egg White Protein ◽  
Protein Levels ◽  
Duck Egg ◽  
Egg Period ◽  
Graph Presentation ◽  
And Control ◽  
The Impact

Background : Egg  is one of the animal protein source, which has delicious taste, easy to digest and highly nutritious. Besides its affordable price, its supply availability is unquestionable as well. However, due to its short storability, it requires special treatment, such as preserving, to store it for long period. One way to preserve the egg is by pickling egg, which generally requires seven to ten days of marinating. During the process of marinating, there will be a visual change of egg white and yolk. Their structures  will be more solid (the occurrence of thickening process) because salinization will lead to protein denaturalization. Consequently, it has an influence as well towards the content of egg white protein of duck egg. This study is aimed to explore the impact of various time of pickling egg towards egg white protein of duck egg. Method  : The study where takes place in a laboratories, is a true experimental study for the reason that the researcher must provide intervention, hence all of potentially confounding variables are manageable. Samples that had been used in this study are duck eggs which were bought from North Brebes. This study is expected to generate data from four various time of pickling egg and control (no treatment). Since there are four samples, accordingly the number of data resulted are twenty. The resulted data will be descriptively presented in table, graph, presentation, and narration. Result  : Protein level examination within duck white egg shows changes  in protein levels that occurs in every variation of pickling egg time, where the average results of the assay of duck egg white protein is 14.94% without treatment (control), in five days of pickling time is 13.68%, in seven days of pickling time is 13.29%, in nine days of pickling time is 12.87% and eleven days of pickling time is 12.78%. Conclusion  : There is a significant impact among the period of pickling time to the protein level degradation of duck white egg. Keywords : Duck egg, period of pickling time, level protein of duck white egg.

Characteristics of Insulin-degrading Enzyme in Alzheimer's Disease: A Meta-Analysis

2018 ◽  
Vol 15 (7) ◽  
pp. 610-617 ◽  
Author(s):  
Huifeng Zhang ◽  
Dan Liu ◽  
Huanhuan Huang ◽  
Yujia Zhao ◽  
Hui Zhou
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Enzyme Activity ◽  
Protein Level ◽  
Senile Plaque ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Insulin Degrading Enzyme ◽  
Degrading Enzyme ◽  
Significant Difference

Background: β-amyloid (Aβ) accumulates abnormally to senile plaque which is the initiator of Alzheimer's disease (AD). As one of the Aβ-degrading enzymes, Insulin-degrading enzyme (IDE) remains controversial for its protein level and activity in Alzheimer's brain. Methods: The electronic databases PubMed, EMBASE, The Cochrane Library, OVID and Sinomed were systemically searched up to Sep. 20th, 2017. And the published case-control or cohort studies were retrieved to perform the meta-analysis. Results: Seven studies for IDE protein level (AD cases = 293; controls = 126), three for mRNA level (AD cases = 138; controls = 81), and three for enzyme activity (AD cases = 123; controls = 75) were pooling together. The IDE protein level was significantly lower in AD cases than in controls (SMD = - 0.47, 95% CI [-0.69, -0.24], p < 0.001), but IDE mRNA and enzyme activity had no significant difference (SMD = 0.02, 95% CI [-0.40, 0.43] and SMD = 0.06, 95% CI [-0.41, 0.53] respectively). Subgroup analyses found that IDE protein level was decreased in both cortex and hippocampus of AD cases (SMD = -0.43, 95% CI [-0.71, -0.16], p = 0.002 and SMD = -0.53, 95% CI [-0.91, -0.15], p = 0.006 respectively). However, IDE mRNA was higher in cortex of AD cases (SMD = 0.71, 95% CI [0.14, 1.29], p = 0.01), not in hippocampus (SMD = -0.26, 95% CI [-0.58, 0.06]). Conclusions: Our results indicate that AD patients may have lower IDE protease level. Further relevant studies are still needed to verify whether IDE is one of the factors affecting Aβ abnormal accumulation and throw new insights for AD detection or therapy.

Covid 19 – Structural proteins and prospective drug candidates (Preprint)

2020 ◽  
Author(s):  
A.N Anoopkumar ◽  
Sharrel Rebello ◽  
Embalil Mathachan Aneesh
Keyword(s):  
Causative Agent ◽  
Protein Level ◽  
Drug Targets ◽  
Current Paper ◽  
Structural Proteins ◽  
Drug Candidates ◽  
Propagation Properties

UNSTRUCTURED Covid 19 the causative agent of the current devastating pandemic has turned out to be a notorious virus to all men-irrespective of either common to scientific calibre. Attempts to combat this deadly virus are the need of the hour and quite often the best way to defeat an opponent is to keenly study about its structural and propagation properties. The current paper describes briefly Covid 19 at the genomic, structural and protein level to the best of our knowledge. Furthermore, the prospects of possible drug targets that could aid in the control of this virus are also discussed.

scholarly journals Predictive factors of perforated appendicitis: Impact of the C-reactive protein level

2021 ◽  
Author(s):  
Shiori Yamazaki ◽  
Yusuke Shimodaira ◽  
Akira Kobayashi ◽  
Manabu Takata ◽  
Kaori Hayashibara ◽  
...  
Keyword(s):  
Predictive Factors ◽  
Protein Level ◽  
Perforated Appendicitis ◽  
C Reactive Protein ◽  
Reactive Protein
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