Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

William Burkitt; Paula Domann; Gavin O'Connor

doi:10.1002/pro.362

Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

Protein Science ◽

10.1002/pro.362 ◽

2010 ◽

Vol 19 (4) ◽

pp. 826-835 ◽

Cited By ~ 73

Author(s):

William Burkitt ◽

Paula Domann ◽

Gavin O'Connor

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Conformational Changes ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Hydrogen Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies

Hydrogen Exchange Mass Spectrometry of Proteins ◽

10.1002/9781118703748.ch18 ◽

2016 ◽

pp. 323-342

Author(s):

Ranajoy Majumdar ◽

C. Russell Middaugh ◽

David D. Weis ◽

David B. Volkin

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Hydrogen Exchange ◽

Analytical Tool ◽

Formulation Development ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry ◽

Therapeutic Monoclonal Antibodies

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Binding of a Diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: A hydrogen exchange mass spectrometry study

Journal of the American Society for Mass Spectrometry ◽

10.1016/j.jasms.2005.02.011 ◽

2005 ◽

Vol 16 (7) ◽

pp. 1039-1051 ◽

Cited By ~ 15

Author(s):

M. Isabel Catalina ◽

Marcel J. E. Fischer ◽

Frank J. Dekker ◽

Rob M. J. Liskamp ◽

Albert J. R. Heck

Keyword(s):

Mass Spectrometry ◽

Tyrosine Kinase ◽

Conformational Changes ◽

Hydrogen Exchange ◽

Spleen Tyrosine Kinase ◽

Exchange Mass Spectrometry ◽

Mass Spectrometry Study ◽

Hydrogen Exchange Mass Spectrometry

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Monitoring the Folding Pathway of a Protein Over Evolutionary Time using Hydrogen Exchange - Mass Spectrometry (HX-MS)

Biophysical Journal ◽

10.1016/j.bpj.2017.11.350 ◽

2018 ◽

Vol 114 (3) ◽

pp. 54a

Author(s):

Eric Bolin ◽

Shion Lim ◽

Susan Marqusee

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Folding Pathway ◽

Evolutionary Time ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Structural Differences in Aβ Amyloid Protofibrils and Fibrils Mapped by Hydrogen Exchange – Mass Spectrometry with On-line Proteolytic Fragmentation

Journal of Molecular Biology ◽

10.1016/j.jmb.2006.06.066 ◽

2006 ◽

Vol 361 (4) ◽

pp. 785-795 ◽

Cited By ~ 98

Author(s):

Indu Kheterpal ◽

Maolian Chen ◽

Kelsey D. Cook ◽

Ronald Wetzel

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Aβ Amyloid ◽

Structural Differences ◽

Hydrogen Exchange Mass Spectrometry ◽

On Line

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Label-Free, In-Solution Screening of Peptide Libraries for Binding to Protein Targets Using Hydrogen Exchange Mass Spectrometry

Journal of the American Chemical Society ◽

10.1021/jacs.5b11742 ◽

2016 ◽

Vol 138 (4) ◽

pp. 1335-1343 ◽

Cited By ~ 8

Author(s):

Walid S. Maaty ◽

David D. Weis

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Peptide Libraries ◽

Label Free ◽

Protein Targets ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody

mAbs ◽

10.1080/19420862.2015.1029217 ◽

2015 ◽

Vol 7 (3) ◽

pp. 525-539 ◽

Cited By ~ 44

Author(s):

Jayant Arora ◽

John M Hickey ◽

Ranajoy Majumdar ◽

Reza Esfandiary ◽

Steven M Bishop ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Hydrogen Exchange ◽

Dynamic Coupling ◽

Coupling Effects ◽

Exchange Mass Spectrometry ◽

Protein Interfaces ◽

Igg1 Monoclonal Antibody ◽

Hydrogen Exchange Mass Spectrometry ◽

Self Association

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Applying Hydrogen Exchange Mass Spectrometry Coupled with Numerical Simulations to Investigate Toxic Misfolding of β2-Microglobulin

Biophysical Journal ◽

10.1016/j.bpj.2018.11.2556 ◽

2019 ◽

Vol 116 (3) ◽

pp. 473a

Author(s):

Angelika Hirsch ◽

John Strahan ◽

Amy Wagaman ◽

Sheila Jaswal

Keyword(s):

Mass Spectrometry ◽

Numerical Simulations ◽

Hydrogen Exchange ◽

Β2 Microglobulin ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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ChemInform Abstract: Hydrogen Exchange Mass Spectrometry for Studying Protein Structure and Dynamics

ChemInform ◽

10.1002/chin.201123278 ◽

2011 ◽

Vol 42 (23) ◽

pp. no-no

Author(s):

Lars Konermann ◽

Jingxi Pan ◽

Yu-Hong Liu

Keyword(s):

Mass Spectrometry ◽

Protein Structure ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Structure And Dynamics ◽

Hydrogen Exchange Mass Spectrometry ◽

Protein Structure And Dynamics

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Probing Protein Structure and Dynamics by Hydrogen Exchange–Mass Spectrometry

Current Protocols in Protein Science ◽

10.1002/0471140864.ps1706s28 ◽

2002 ◽

Vol 28 (1) ◽

Cited By ~ 3

Author(s):

Lintao Wang ◽

David L. Smith

Keyword(s):

Mass Spectrometry ◽

Protein Structure ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Structure And Dynamics ◽

Hydrogen Exchange Mass Spectrometry ◽

Protein Structure And Dynamics

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Hydrogen Exchange Mass Spectrometry for Conformational Analysis of Proteins

Encyclopedia of Analytical Chemistry ◽

10.1002/9780470027318.a9201 ◽

2011 ◽

Cited By ~ 6

Author(s):

John R. Engen ◽

Thomas E. Wales ◽

Xiaomeng Shi

Keyword(s):

Mass Spectrometry ◽

Conformational Analysis ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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