scholarly journals Functional analysis of iodotyrosine deiodinase from drosophila melanogaster

2016 ◽  
Vol 25 (12) ◽  
pp. 2187-2195 ◽  
Author(s):  
Abhishek Phatarphekar ◽  
Steven E. Rokita
Keyword(s):  
Functional Analysis ◽  
Drosophila Melanogaster ◽  
Iodotyrosine Deiodinase

Functional analysis of poly(ADP-ribose) polymerase in Drosophila melanogaster

1999 ◽  
pp. 103-107
Author(s):  
Masanao Miwa ◽  
Shuji Hanai ◽  
Palmiro Poltronieri ◽  
Masahiro Uchida ◽  
Kazuhiko Uchida
Keyword(s):  
Functional Analysis ◽  
Drosophila Melanogaster

Functional analysis of Drosophila melanogaster BRCA2 in DNA repair

DNA Repair ◽  
2008 ◽  
Vol 7 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Rachel Brough ◽  
Debbie Wei ◽  
Sophie Leulier ◽  
Christopher J. Lord ◽  
Yikang S. Rong ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Dna Repair ◽  
Drosophila Melanogaster

Genomic organization and functional analysis of a deletion variant of the 87A7 heat shock locus of Drosophila melanogaster

1982 ◽  
Vol 155 (3) ◽  
pp. 267-280 ◽  
Author(s):  
Andor Udvardy ◽  
János Sümegi ◽  
Éva Csordás Tóth ◽  
János Gausz ◽  
Henrik Gyurkovics ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Drosophila Melanogaster ◽  
Heat Shock ◽  
Genomic Organization ◽  
Deletion Variant ◽  
Shock Locus

scholarly journals Functional analysis of Aarf domain‐containing kinase 1 in Drosophila melanogaster

2019 ◽  
Vol 248 (9) ◽  
pp. 762-770 ◽  
Author(s):  
Dona R. Wisidagama ◽  
Stefan M. Thomas ◽  
Geanette Lam ◽  
Carl S. Thummel
Keyword(s):  
Functional Analysis ◽  
Drosophila Melanogaster

Functional analysis of LCR sequences from the cut locus of Drosophila melanogaster

2007 ◽  
Vol 415 (1) ◽  
pp. 217-221 ◽  
Author(s):  
N. A. Tchurikov ◽  
D. V. Sosin ◽  
O. V. Kretova ◽  
E. D. Moiseeva
Keyword(s):  
Functional Analysis ◽  
Drosophila Melanogaster ◽  
Cut Locus

Functional analysis of sepiapterin reductase in Drosophila melanogaster

Pteridines ◽  
2015 ◽  
Vol 26 (2) ◽  
pp. 63-68
Author(s):  
Kiyoung Kim ◽  
Heuijong Kim ◽  
Jeongbin Yim
Keyword(s):  
Oxidative Stress ◽  
Functional Analysis ◽  
Drosophila Melanogaster ◽  
Neurological Disorders ◽  
Biochemical Analysis ◽  
Akt Pathway ◽  
Loss Of Function ◽  
Sepiapterin Reductase ◽  
Phosphorylated Akt ◽  
Key Enzyme

AbstractSepiapterin reductase (SR) is a key enzyme involved in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of important biogenic amines, including catecholamines and serotonin. BH4 deficiencies have been implicated in several neurological disorders. Here, we characterized sepiapterin reductase (SR) loss-of-function mutants in Drosophila melanogaster and demonstrated that SR mutations are responsible for hyposensitivity to oxidative stress. Biochemical analysis further revealed that SR activity and BH4 levels in SR mutants were significantly reduced. Furthermore, we showed that the levels of phosphorylated Akt and total Akt protein were increased in SR mutants. Our findings indicate that SR plays an important role in the Akt pathway and that SR mutants will be a valuable tool for investigating the physiological functions of BH4.

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