scholarly journals Carboxylic ester hydrolases: Classification and database derived from their primary, secondary, and tertiary structures

2016 ◽  
Vol 25 (11) ◽  
pp. 1942-1953 ◽  
Author(s):  
Yingfei Chen ◽  
Daniel S. Black ◽  
Peter J. Reilly
Keyword(s):  
Tertiary Structures ◽  
Carboxylic Ester ◽  
Ester Hydrolases

scholarly journals Carboxylic Ester Hydrolases in Bacteria: Active Site, Structure, Function and Application

Crystals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 597 ◽  
Author(s):  
Changsuk Oh ◽  
T. Doohun Kim ◽  
Kyeong Kyu Kim
Keyword(s):  
Acyl Chain ◽  
Data Bank ◽  
Industrial Applications ◽  
Head Group ◽  
Carboxylic Ester ◽  
Site Structure ◽  
Domains Of Life ◽  
Carboxylic Esters ◽  
Hydrolysis Of ◽  
Ester Hydrolases

Carboxylic ester hydrolases (CEHs), which catalyze the hydrolysis of carboxylic esters to produce alcohol and acid, are identified in three domains of life. In the Protein Data Bank (PDB), 136 crystal structures of bacterial CEHs (424 PDB codes) from 52 genera and metagenome have been reported. In this review, we categorize these structures based on catalytic machinery, structure and substrate specificity to provide a comprehensive understanding of the bacterial CEHs. CEHs use Ser, Asp or water as a nucleophile to drive diverse catalytic machinery. The α/β/α sandwich architecture is most frequently found in CEHs, but 3-solenoid, β-barrel, up-down bundle, α/β/β/α 4-layer sandwich, 6 or 7 propeller and α/β barrel architectures are also found in these CEHs. Most are substrate-specific to various esters with types of head group and lengths of the acyl chain, but some CEHs exhibit peptidase or lactamase activities. CEHs are widely used in industrial applications, and are the objects of research in structure- or mutation-based protein engineering. Structural studies of CEHs are still necessary for understanding their biological roles, identifying their structure-based functions and structure-based engineering and their potential industrial applications.

Carboxylic ester hydrolases in mitochondria from rat skeletal muscle

1990 ◽  
Vol 22 (2) ◽  
pp. 95-101 ◽  
Author(s):  
S. Kirkeby ◽  
D. Moe ◽  
T. Zelander
Keyword(s):  
Skeletal Muscle ◽  
Rat Skeletal Muscle ◽  
Carboxylic Ester ◽  
Ester Hydrolases

scholarly journals Carboxylic ester hydrolases from hyperthermophiles

Extremophiles ◽  
2009 ◽  
Vol 13 (4) ◽  
pp. 567-581 ◽  
Author(s):  
Mark Levisson ◽  
John van der Oost ◽  
Servé W. M. Kengen
Keyword(s):  
Carboxylic Ester ◽  
Ester Hydrolases

Aspidogaster conchicola: Histochemical localization of carboxylic ester hydrolases

1972 ◽  
Vol 32 (2) ◽  
pp. 181-190 ◽  
Author(s):  
John J. Trimble ◽  
Horace H. Bailey ◽  
Ann Sheppard
Keyword(s):  
Histochemical Localization ◽  
Carboxylic Ester ◽  
Ester Hydrolases

Preliminary characterization of some plant carboxylic ester hydrolases

1963 ◽  
Vol 2 (3) ◽  
pp. 263-271 ◽  
Author(s):  
Jasper van der W. Jooste ◽  
Donald E. Moreland
Keyword(s):  
Carboxylic Ester ◽  
Preliminary Characterization ◽  
Ester Hydrolases

scholarly journals Carboxylic ester hydrolases of rat pancreatic juice

1966 ◽  
Vol 7 (4) ◽  
pp. 536-543
Author(s):  
F.H. Mattson ◽  
R.A. Volpenhein
Keyword(s):  
Pancreatic Juice ◽  
Carboxylic Ester ◽  
Ester Hydrolases

Carboxylic Ester Hydrolases of Apple

1981 ◽  
Vol 32 (4) ◽  
pp. 741-751 ◽  
Author(s):  
IAN M. BARTLEY ◽  
WILLIAM H. STEVENS
Keyword(s):  
Carboxylic Ester ◽  
Ester Hydrolases
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