scholarly journals The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei

2009 ◽  
Vol 18 (12) ◽  
pp. 2578-2591 ◽  
Author(s):  
Sarah E. Dobson ◽  
Kevin D. Augustijn ◽  
James A. Brannigan ◽  
Claudia Schnick ◽  
Chris J. Janse ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Crystal Structures ◽  
Migration Inhibitory Factor ◽  
Plasmodium Berghei ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration

scholarly journals Immunohistological Characterization of Macrophage Migration Inhibitory Factor Expression in Plasmodium falciparum-Infected Placentas

2005 ◽  
Vol 73 (6) ◽  
pp. 3287-3293 ◽  
Author(s):  
Sujittra Chaisavaneeyakorn ◽  
Naomi Lucchi ◽  
Carlos Abramowsky ◽  
Caroline Othoro ◽  
Sansanee C. Chaiyaroj ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Mononuclear Cells ◽  
Placental Malaria ◽  
Inhibitory Factor ◽  
Immunoperoxidase Staining ◽  
Macrophage Migration ◽  
Human Trophoblast ◽  
Hofbauer Cells

ABSTRACT Previously, we have shown that macrophage migration inhibitory factor (MIF) was highly elevated in the placental intervillous blood (IVB) of Plasmodium falciparum-infected women. Here, we compared the expression of MIF in placental tissues obtained from P. falciparum-infected and -uninfected women. Immunoperoxidase staining showed a consistent pattern of MIF expression in syncytiotrophoblasts, extravillous trophoblasts, IVB mononuclear cells, and amniotic epithelial cells, irrespective of their malaria infection status. Cytotrophoblast, villous stroma, and Hofbauer cells showed focal staining. Only amniotic epithelial and IVB mononuclear cells from P. falciparum-infected placentas exhibited significantly higher level of MIF expression than uninfected placentas. Stimulation of syncytilized human trophoblast BeWo cells with P. falciparum-infected erythrocytes that were selected to bind these cells resulted in significant increases in MIF secretion, whereas control erythrocytes, lipopolysaccharides, and synthetic β-hematin had minimal effect. These findings suggest that placental malaria modulates MIF expression in different placental compartments.

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