Clinical applications of capillary electrophoresis coupled to mass spectrometry in biomarker discovery: Focus on bladder cancer

2013 ◽  
Vol 7 (11-12) ◽  
pp. 779-793 ◽  
Author(s):  
Agnieszka Latosinska ◽  
Maria Frantzi ◽  
Antonia Vlahou ◽  
Harald Mischak
Keyword(s):  
Mass Spectrometry ◽  
Bladder Cancer ◽  
Capillary Electrophoresis ◽  
Biomarker Discovery ◽  
Clinical Applications

Challenges of using mass spectrometry as a bladder cancer biomarker discovery platform

2008 ◽  
Vol 26 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Eric Schiffer ◽  
Harald Mischak ◽  
Dan Theodorescu ◽  
Antonia Vlahou
Keyword(s):  
Mass Spectrometry ◽  
Bladder Cancer ◽  
Biomarker Discovery ◽  
Cancer Biomarker

scholarly journals Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery

2014 ◽  
Vol 11 (1) ◽  
pp. 14 ◽  
Author(s):  
Huan Liu ◽  
Ningbo Zhang ◽  
Debin Wan ◽  
Meng Cui ◽  
Zhiqiang Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Biomarker Discovery ◽  
Clinical Applications ◽  
Cancer Biomarker

scholarly journals Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery

2017 ◽  
Vol 4 (7) ◽  
pp. 203-215
Author(s):  
Farid Abu Shammala
Keyword(s):  
Mass Spectrometry ◽  
Posttranslational Modifications ◽  
Biomarker Discovery ◽  
Global Analysis ◽  
Structural Identification ◽  
Clinical Applications ◽  
Biological Processes ◽  
Complex Sample ◽  
Systematic Identification ◽  
Glycoprotein Glycosylation

Most proteins are glycosylated, glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods for analysis of aberrant glycoproteins associated with diseases. With recent advances in proteomics, analytical and computational technologies, glycoproteomics, the global analysis of glycoproteins, is rapidly emerging as a subfield of proteomics with high biological and clinical relevance. Glycoproteomics integrates glycoprotein enrichment and proteomics technologies to support the systematic identification and quantification of glycoproteins in a complex sample. It is especially critical to develop the rapid and sensitive methods for analysis of aberrant glycoproteins associated with diseases. Mass spectrometry (MS) has become a powerful tool for mapping glycoprotein glycosylation and detailed glycan structural determination. Especially, tandem mass spectrometry can provide highly informative fragments for structural identification of glycoproteins. This review provides an overview of the development of MS technologies and their applications in identification of abnormal glycoproteins and glycans in human serum to screen cancer biomarkers in recent years.

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