Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis

2013 ◽  
Vol 7 (9-10) ◽  
pp. 648-656 ◽  
Author(s):  
Yoshihiro Kamada ◽  
Hideki Fujii ◽  
Hironobu Fujii ◽  
Yoshiyuki Sawai ◽  
Yoshinori Doi ◽  
...  
Keyword(s):  
Disease Severity ◽  
Nonalcoholic Steatohepatitis ◽  
Binding Protein ◽  
Diagnostic Biomarker ◽  
Protein Levels

scholarly journals Correction: Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205541
Author(s):  
Naim Alkhouri ◽  
Casey Johnson ◽  
Leon Adams ◽  
Sachiko Kitajima ◽  
Chikayuki Tsuruno ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Binding Protein ◽  
Protein Levels ◽  
Wisteria Floribunda

scholarly journals Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202226 ◽  
Author(s):  
Naim Alkhouri ◽  
Casey Johnson ◽  
Leon Adams ◽  
Sachiko Kitajima ◽  
Chikayuki Tsuruno ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Binding Protein ◽  
Protein Levels ◽  
Wisteria Floribunda

Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with bone disease severity in Rett syndrome

2019 ◽  
Author(s):  
Carla Caffarelli ◽  
Tomai Pitinca Maria Dea ◽  
Valentina Francolini ◽  
Roberto Canitano ◽  
felice Claudio De ◽  
...  
Keyword(s):  
Disease Severity ◽  
Rett Syndrome ◽  
Bone Disease ◽  
Binding Protein ◽  
Mecp2 Mutation ◽  
Mutation Type

Growth hormone-binding protein levels: Studies of children with short stature

Metabolism ◽  
1994 ◽  
Vol 43 (3) ◽  
pp. 357-359 ◽  
Author(s):  
Nelly Mauras ◽  
Lena M.S. Carlsson ◽  
Suzanne Murphy ◽  
Thomas J. Merimee
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Binding Protein ◽  
Hormone Binding ◽  
Protein Levels ◽  
Growth Hormone Binding Protein ◽  
Hormone Binding Protein

scholarly journals The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway

2006 ◽  
Vol 398 (2) ◽  
pp. 215-224 ◽  
Author(s):  
Sara Sánchez-Molina ◽  
José Luis Oliva ◽  
Susana García-Vargas ◽  
Ester Valls ◽  
José M. Rojas ◽  
...  
Keyword(s):  
Binding Protein ◽  
Camp Response Element Binding ◽  
Signalling Pathway ◽  
3T3 Cells ◽  
Protein Levels ◽  
3T3 Fibroblasts ◽  
Differentiation And Proliferation ◽  
Nih 3T3 ◽  
Ras Signalling ◽  
Nih 3T3 Cells

The CBP [CREB (cAMP-response-element-binding protein)-binding protein]/p300 acetyltransferases function as transcriptional co-activators and play critical roles in cell differentiation and proliferation. Accumulating evidence shows that alterations of the CBP/p300 protein levels are linked to human tumours. In the present study, we show that the levels of the CBP/p300 co-activators are decreased dramatically by continuous PDGF (platelet-derived growth factor) and Ras signalling pathway activation in NIH 3T3 fibroblasts. This effect occurs by reducing the expression levels of the CBP/p300 genes. In addition, CBP and p300 are degraded by the 26 S proteasome pathway leading to an overall decrease in the levels of the CBP/p300 proteins. Furthermore, we provide evidence that Mdm2 (murine double minute 2), in the presence of active H-Ras or N-Ras, induces CBP/p300 degradation in NIH 3T3 cells. These findings support a novel mechanism for modulating other signalling transduction pathways that require these common co-activators.

scholarly journals Methyl-CpG-binding protein 2(MECP2) mutation type is associated with disease severity in Rett syndrome

2014 ◽  
Vol 51 (3) ◽  
pp. 152-158 ◽  
Author(s):  
Vishnu Anand Cuddapah ◽  
Rajesh B Pillai ◽  
Kiran V Shekar ◽  
Jane B Lane ◽  
Kathleen J Motil ◽  
...  
Keyword(s):  
Disease Severity ◽  
Rett Syndrome ◽  
Binding Protein ◽  
Mecp2 Mutation ◽  
Mutation Type
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