scholarly journals Proteome and transcriptome profiles of a Her2/Neu-driven mouse model of breast cancer

2011 ◽  
Vol 5 (3-4) ◽  
pp. 179-188 ◽  
Author(s):  
Regine M. Schoenherr ◽  
Karen S. Kelly-Spratt ◽  
ChenWei Lin ◽  
Jeffrey R. Whiteaker ◽  
Tao Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Model

Aging, Breast Cancer, and the Mouse Model

2003 ◽  
Author(s):  
Simona Parrinello ◽  
Judith Campisi
Keyword(s):  
Breast Cancer ◽  
Mouse Model

scholarly journals Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Vidya C. Sinha ◽  
Amanda L. Rinkenbaugh ◽  
Mingchu Xu ◽  
Xinhui Zhou ◽  
Xiaomei Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Mouse Model ◽  
Transition State ◽  
Tumor Cell ◽  
Single Cell ◽  
Tumor Cells ◽  
Breast Lesions ◽  
Aggressive Tumor ◽  
Insight Into

AbstractThere is an unmet clinical need for stratification of breast lesions as indolent or aggressive to tailor treatment. Here, single-cell transcriptomics and multiparametric imaging applied to a mouse model of breast cancer reveals that the aggressive tumor niche is characterized by an expanded basal-like population, specialization of tumor subpopulations, and mixed-lineage tumor cells potentially serving as a transition state between luminal and basal phenotypes. Despite vast tumor cell-intrinsic differences, aggressive and indolent tumor cells are functionally indistinguishable once isolated from their local niche, suggesting a role for non-tumor collaborators in determining aggressiveness. Aggressive lesions harbor fewer total but more suppressed-like T cells, and elevated tumor-promoting neutrophils and IL-17 signaling, disruption of which increase tumor latency and reduce the number of aggressive lesions. Our study provides insight into tumor-immune features distinguishing indolent from aggressive lesions, identifies heterogeneous populations comprising these lesions, and supports a role for IL-17 signaling in aggressive progression.

scholarly journals Tobacco mosaic virus delivery of mitoxantrone for cancer therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (34) ◽  
pp. 16307-16313 ◽  
Author(s):  
Richard D. Lin ◽  
Nicole F. Steinmetz
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Mouse Model ◽  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Triple Negative Breast Cancer ◽  
Topoisomerase Ii ◽  
Triple Negative ◽  
Topoisomerase Ii Inhibitor ◽  
Virus Delivery

Tobacco mosaic virus-nanoparticle encapsulation of the topoisomerase II inhibitor mitoxantrone enables therapy in a mouse model of triple negative breast cancer.

CD105 expression and usefulness of its targeting for antivascular alpha radioimmunotherapy in a mouse model of breast cancer

2015 ◽  
Vol 152 (1) ◽  
pp. 46
Author(s):  
L. Dorso ◽  
L. Abadie ◽  
C. Sai-Maurel ◽  
M. Cherel M ◽  
F. Davodeau
Keyword(s):  
Breast Cancer ◽  
Mouse Model
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