Comparative proteomic analysis to discover potential therapeutic targets in human multiple myeloma

2009 ◽  
Vol 3 (11) ◽  
pp. 1348-1360 ◽  
Author(s):  
Chuan-Le Xiao ◽  
Zhi-Ping Zhang ◽  
Sheng Xiong ◽  
Chun-Hua Lu ◽  
Hong-Ping Wei ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Proteomic Analysis ◽  
Therapeutic Targets ◽  
Comparative Proteomic Analysis ◽  
Human Multiple Myeloma

scholarly journals Comparative proteomic analysis of skin fibroblasts of patients with familial Alzheimer's and healthy controls: Searching for new therapeutic targets

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Gustavo Lopez‐Toledo ◽  
Maria del Carmen Silva‐Lucero ◽  
Jose Antonio Arias‐Montaño ◽  
Mariaarmen del CCardenas‐Aguayo
Keyword(s):  
Proteomic Analysis ◽  
Therapeutic Targets ◽  
Skin Fibroblasts ◽  
Healthy Controls ◽  
Comparative Proteomic Analysis ◽  
New Therapeutic Targets

Bone sialoprotein mRNA and protein expression in human multiple myeloma cell lines and patients

2000 ◽  
Vol 111 (4) ◽  
pp. 1118-1121 ◽  
Author(s):  
A. Bellahcene ◽  
I. Van Riet ◽  
C. de Greef ◽  
N. Antoine ◽  
M. F. Young ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Protein Expression ◽  
Cell Lines ◽  
Myeloma Cell ◽  
Bone Sialoprotein ◽  
Multiple Myeloma Cell ◽  
Human Multiple Myeloma ◽  
Mrna And Protein Expression

scholarly journals Proteome Profiling of PMJ2-R and Primary Peritoneal Macrophages

2021 ◽  
Vol 22 (12) ◽  
pp. 6323
Author(s):  
Alexander L. Rusanov ◽  
Peter M. Kozhin ◽  
Olga V. Tikhonova ◽  
Victor G. Zgoda ◽  
Dmitry S. Loginov ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Living Organism ◽  
Peritoneal Macrophages ◽  
In Vitro Models ◽  
Individual Characteristics ◽  
Essential Proteins ◽  
Comparative Proteomic Analysis ◽  
Immortalized Cell ◽  
The Individual

In vitro models are often used for studying macrophage functions, including the process of phagocytosis. The application of primary macrophages has limitations associated with the individual characteristics of animals, which can lead to insufficient standardization and higher variability of the obtained results. Immortalized cell lines do not have these disadvantages, but their responses to various signals can differ from those of the living organism. In the present study, a comparative proteomic analysis of immortalized PMJ2-R cell line and primary peritoneal macrophages isolated from C57BL/6 mice was performed. A total of 4005 proteins were identified, of which 797 were quantified. Obtained results indicate significant differences in the abundances of many proteins, including essential proteins associated with the process of phagocytosis, such as Elmo1, Gsn, Hspa8, Itgb1, Ncf2, Rac2, Rack1, Sirpa, Sod1, C3, and Msr1. These findings indicate that outcomes of studies utilizing PMJ2-R cells as a model of peritoneal macrophages should be carefully validated. All MS data are deposited in ProteomeXchange with the identifier PXD022133.

scholarly journals Comparative proteomic analysis of mitochondria isolated from Euglena gracilis under aerobic and hypoxic conditions

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0227226 ◽  
Author(s):  
Shun Tamaki ◽  
Kohei Nishino ◽  
Takahisa Ogawa ◽  
Takanori Maruta ◽  
Yoshihiro Sawa ◽  
...  
Keyword(s):  
Euglena Gracilis ◽  
Proteomic Analysis ◽  
Comparative Proteomic Analysis ◽  
Hypoxic Conditions
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