scholarly journals Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

2009 ◽  
Vol 3 (6) ◽  
pp. 682-693 ◽  
Author(s):  
Marzia Perluigi ◽  
Rukhsana Sultana ◽  
Giovanna Cenini ◽  
Fabio Di Domenico ◽  
Maurizio Memo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lipid Peroxidation ◽  
Disease Pathogenesis ◽  
Redox Proteomics ◽  
Brain Proteins

scholarly journals Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

2021 ◽  
Vol 22 (7) ◽  
pp. 3330
Author(s):  
Mehdi Eshraghi ◽  
Aida Adlimoghaddam ◽  
Amir Mahmoodzadeh ◽  
Farzaneh Sharifzad ◽  
Hamed Yasavoli-Sharahi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Neurological Disorder ◽  
Inflammatory Cells ◽  
Disease Pathogenesis ◽  
Current Review ◽  
The Brain ◽  
Comprehensive Discussion

Alzheimer’s disease (AD) is a debilitating neurological disorder, and currently, there is no cure for it. Several pathologic alterations have been described in the brain of AD patients, but the ultimate causative mechanisms of AD are still elusive. The classic hallmarks of AD, including am-yloid plaques (Aβ) and tau tangles (tau), are the most studied features of AD. Unfortunately, all the efforts targeting these pathologies have failed to show the desired efficacy in AD patients so far. Neuroinflammation and impaired autophagy are two other main known pathologies in AD. It has been reported that these pathologies exist in AD brain long before the emergence of any clinical manifestation of AD. Microglia are the main inflammatory cells in the brain and are considered by many researchers as the next hope for finding a viable therapeutic target in AD. Interestingly, it appears that the autophagy and mitophagy are also changed in these cells in AD. Inside the cells, autophagy and inflammation interact in a bidirectional manner. In the current review, we briefly discussed an overview on autophagy and mitophagy in AD and then provided a comprehensive discussion on the role of these pathways in microglia and their involvement in AD pathogenesis.

The Potential Role of Rho GTPases in Alzheimer's Disease Pathogenesis

2014 ◽  
Vol 50 (2) ◽  
pp. 406-422 ◽  
Author(s):  
Silvia Bolognin ◽  
Erika Lorenzetto ◽  
Giovanni Diana ◽  
Mario Buffelli
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rho Gtpases ◽  
Potential Role ◽  
Disease Pathogenesis

Role of Cytosolic Calcium-Dependent Phospholipase A2 in Alzheimer's Disease Pathogenesis

2012 ◽  
Vol 45 (3) ◽  
pp. 596-604 ◽  
Author(s):  
M. T. Gentile ◽  
M. G. Reccia ◽  
P. P. Sorrentino ◽  
E. Vitale ◽  
G. Sorrentino ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Phospholipase A2 ◽  
Cytosolic Calcium ◽  
Disease Pathogenesis ◽  
Calcium Dependent

Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer’s disease pathogenesis

2022 ◽  
pp. JN-RM-2039-21
Author(s):  
Sadequl Islam ◽  
Yang Sun ◽  
Yuan Gao ◽  
Tomohisa Nakamura ◽  
Arshad Ali Noorani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Pathogenesis
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