scholarly journals Characterization of the renal cyst fluid proteome in autosomal dominant polycystic kidney disease (ADPKD) patients

2008 ◽  
Vol 2 (7-8) ◽  
pp. 1140-1152 ◽  
Author(s):  
Xianyin Lai ◽  
Robert L. Bacallao ◽  
Bonnie L. Blazer-Yost ◽  
David Hong ◽  
Stephen B. Mason ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Renal Cyst ◽  
Cyst Fluid ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals Renal cyst fluid proteomics in autosomal dominant polycystic kidney disease (ADPKD)

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Xianyin Lai ◽  
Robert L. Bacallao ◽  
Bonnie L. Blazer‐Yost ◽  
David Hong ◽  
Stephen B. Mason ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Renal Cyst ◽  
Cyst Fluid ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals Obacunone Retards Renal Cyst Development in Autosomal Dominant Polycystic Kidney Disease by Activating NRF2

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 38
Author(s):  
Zhiwei Qiu ◽  
Jinzhao He ◽  
Guangying Shao ◽  
Jiaqi Hu ◽  
Xiaowei Li ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Renal Cyst ◽  
Renal Diseases ◽  
Therapeutic Drug ◽  
Dependent Manner ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney ◽  
Cyst Development

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterized by progressive enlargement of fluid-filled cysts derived from renal tubular epithelial cells, which has become the fourth leading cause of end-stage renal diseases. Currently, treatment options for ADPKD remain limited. The purpose of this study was to discover an effective therapeutic drug for ADPKD. With virtual screening, Madin-Darby canine kidney (MDCK) cyst model, embryonic kidney cyst model and kidney-specific Pkd1 knockout mouse (PKD) model, we identified obacunone as a candidate compound for ADPKD drug discovery from a natural antioxidant compound library. In vitro experiments showed that obacunone significantly inhibited cyst formation and expansion of MDCK cysts and embryonic kidney cysts in a dose-dependent manner. In vivo, obacunone treatment significantly reduced the renal cyst development in PKD mice. Western blot and morphological analysis revealed that obacunone served as a NRF2 activator in ADPKD, which suppressed lipid peroxidation by up-regulating GPX4 and finally restrained excessive cell proliferation by down-regulating mTOR and MAPK signaling pathways. Experimental data demonstrated obacunone as an effective renal cyst inhibitor for ADPKD, indicating that obacunone might be developed into a therapeutic drug for ADPKD treatment.

scholarly journals Gas-forming infection in a renal cyst of a patient with autosomal dominant polycystic kidney disease

2005 ◽  
Vol 21 (2) ◽  
pp. 555-556 ◽  
Author(s):  
Reha Erkoc ◽  
Hayriye Sayarlioglu ◽  
Kadir Ceylan ◽  
Ekrem Dogan ◽  
Pinar Sonat Kara
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Renal Cyst ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney
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