Vitamins A, D, E status as related to supplementation and lung disease markers in young children with cystic fibrosis

2022 ◽  
Author(s):  
HuiChuan J. Lai ◽  
Lyanne H. Chin ◽  
Sangita Murali ◽  
Taiya Bach ◽  
Danielle Sander ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Lung Disease ◽  
Disease Markers

Regional differences in infection and structural lung disease in infants and young children with cystic fibrosis

2020 ◽  
Vol 19 (6) ◽  
pp. 917-922 ◽  
Author(s):  
Rosemary Carzino ◽  
Katherine B. Frayman ◽  
Louise King ◽  
Suzanna Vidmar ◽  
Sarath Ranganathan
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Lung Disease ◽  
Regional Differences ◽  
Infants And Young Children

scholarly journals PRAGMA-CF. A Quantitative Structural Lung Disease Computed Tomography Outcome in Young Children with Cystic Fibrosis

2015 ◽  
Vol 191 (10) ◽  
pp. 1158-1165 ◽  
Author(s):  
Tim Rosenow ◽  
Merel C. J. Oudraad ◽  
Conor P. Murray ◽  
Lidija Turkovic ◽  
Wieying Kuo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cystic Fibrosis ◽  
Young Children ◽  
Lung Disease

scholarly journals WS08.2 Objective diagnosis of early structural lung disease on chest CT: assessment of airway and artery dimensions in young children with cystic fibrosis

2016 ◽  
Vol 15 ◽  
pp. S13
Author(s):  
W. Kuo ◽  
T. Soffers ◽  
T. Rosenow ◽  
A. Perez-Rovira ◽  
E.R. Andinopoulou ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Lung Disease ◽  
Chest Ct

scholarly journals Genomic Diversity and Antimicrobial Resistance of Haemophilus Colonizing the Airways of Young Children with Cystic Fibrosis

mSystems ◽  
2021 ◽  
Vol 6 (4) ◽  
Author(s):  
Stephen C. Watts ◽  
Louise M. Judd ◽  
Rosemary Carzino ◽  
Sarath Ranganathan ◽  
Kathryn E. Holt
Keyword(s):  
Cystic Fibrosis ◽  
Antimicrobial Resistance ◽  
Young Children ◽  
Lung Disease ◽  
Respiratory Infections ◽  
Genomic Diversity ◽  
Disease Development ◽  
Acute Respiratory Infections ◽  
Early Disease ◽  
Advanced Stages

Cystic fibrosis (CF) lung disease begins during infancy, and acute respiratory infections increase the risk of early disease development and progression. Microbes involved in advanced stages of CF are well characterized, but less is known about early respiratory colonizers.

Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-216085
Author(s):  
Katie J Bayfield ◽  
Tonya A Douglas ◽  
Tim Rosenow ◽  
Jane Carolyn Davies ◽  
Stuart J Elborn ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Young Children ◽  
Lung Disease ◽  
Structural Changes ◽  
Safety Data ◽  
Clinical Signs ◽  
Later Life ◽  
Birth Cohorts ◽  
Research Questions

Structural and functional defects within the lungs of children with cystic fibrosis (CF) are detectable soon after birth and progress throughout preschool years often without overt clinical signs or symptoms. By school age, most children have structural changes such as bronchiectasis or gas trapping/hypoperfusion and lung function abnormalities that persist into later life. Despite improved survival, gains in forced expiratory volume in one second (FEV1) achieved across successive birth cohorts during childhood have plateaued, and rates of FEV1 decline in adolescence and adulthood have not slowed. This suggests that interventions aimed at preventing lung disease should be targeted to mild disease and commence in early life. Spirometry-based classifications of ‘normal’ (FEV1≥90% predicted) and ‘mild lung disease’ (FEV1 70%–89% predicted) are inappropriate, given the failure of spirometry to detect significant structural or functional abnormalities shown by more sensitive imaging and lung function techniques. The state and readiness of two imaging (CT and MRI) and two functional (multiple breath washout and oscillometry) tools for the detection and monitoring of early lung disease in children and adults with CF are discussed in this article.Prospective research programmes and technological advances in these techniques mean that well-designed interventional trials in early lung disease, particularly in young children and infants, are possible. Age appropriate, randomised controlled trials are critical to determine the safety, efficacy and best use of new therapies in young children. Regulatory bodies continue to approve medications in young children based on safety data alone and extrapolation of efficacy results from older age groups. Harnessing the complementary information from structural and functional tools, with measures of inflammation and infection, will significantly advance our understanding of early CF lung disease pathophysiology and responses to therapy. Defining clinical utility for these novel techniques will require effective collaboration across multiple disciplines to address important remaining research questions. Future impact on existing management burden for patients with CF and their family must be considered, assessed and minimised.To address the possible role of these techniques in early lung disease, a meeting of international leaders and experts in the field was convened in August 2019 at the Australiasian Cystic Fibrosis Conference. The meeting entitiled ‘Shaping imaging and functional testing for early disease detection of lung disease in Cystic Fibrosis’, was attended by representatives across the range of disciplines involved in modern CF care. This document summarises the proceedings, key priorities and important research questions highlighted.

scholarly journals Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography

2017 ◽  
Vol 52 (11) ◽  
pp. 1414-1423 ◽  
Author(s):  
Wieying Kuo ◽  
Thomas Soffers ◽  
Eleni-Rosalina Andrinopoulou ◽  
Tim Rosenow ◽  
Sarath Ranganathan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cystic Fibrosis ◽  
Young Children ◽  
Lung Disease ◽  
Quantitative Assessment ◽  
Cystic Fibrosis Lung ◽  
Chest Computed Tomography ◽  
Cystic Fibrosis Lung Disease ◽  
Airway Dimensions

scholarly journals Progression of early structural lung disease in young children with cystic fibrosis assessed using CT

Thorax ◽  
2011 ◽  
Vol 67 (6) ◽  
pp. 509-516 ◽  
Author(s):  
Lauren S Mott ◽  
Judy Park ◽  
Conor P Murray ◽  
Catherine L Gangell ◽  
Nicholas H de Klerk ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Lung Disease
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