Epidemiologic evaluation of inhaled nitric oxide use among neonates with gestational age less than 35 weeks

2021 ◽  
Author(s):  
Allison M. Peluso ◽  
Hasan F. Othman ◽  
Sreenivas Karnati ◽  
Ibrahim Sammour ◽  
Hany Z. Aly
Keyword(s):  
Nitric Oxide ◽  
Gestational Age ◽  
Inhaled Nitric Oxide

Birth Size and Gestational Age Specific Outcomes of Inhaled Nitric Oxide Therapy in Preterm Neonates with Clinically Diagnosed Pulmonary Hypertension

2019 ◽  
Vol 36 (14) ◽  
pp. 1471-1480
Author(s):  
Carley J. Udland ◽  
William A. Carey ◽  
Amy L. Weaver ◽  
Kristin C. Mara ◽  
Reese H. Clark ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Propensity Score ◽  
Gestational Age ◽  
Early Treatment ◽  
Cox Proportional Hazards ◽  
Inhaled Nitric Oxide ◽  
Preterm Neonates ◽  
Birth Size ◽  
Inhospital Mortality

Objective Among neonates of 22 to 29 weeks' gestational age (GA) who required mechanical ventilation for the treatment of respiratory distress syndrome (RDS) and clinically diagnosed pulmonary hypertension (PH), we tested our hypothesis that the association between early treatment with inhaled nitric oxide (iNO) and survival would vary according to birth size and GA. Study Design Because iNO was not randomly prescribed to patients in this cohort, we used propensity score matching to pair a neonate who received iNO at a chronological age of ≤7 days with an unexposed neonate with similar baseline characteristics. The primary outcome was inhospital mortality, which we evaluated based on size for GA and GA strata using the Cox proportional hazards regression model. Results Among 1,531 neonates who met study criteria, we created a propensity score matched cohort of 615 pairs of neonates (iNO-exposed and unexposed). The risk of inhospital mortality for iNO-exposed neonates was observed only in the minority (<10%) who were large for GA, though this finding did not persist when matching for illness severity. Conclusion Early treatment with iNO is not associated with survival in most extremely premature neonates with RDS and clinically diagnosed PH when stratified for birth size or GA.

Cost-Effectiveness of Inhaled Nitric Oxide in the Treatment of Neonatal Respiratory Failure in the United States

PEDIATRICS ◽  
2003 ◽  
Vol 112 (6) ◽  
pp. 1351-1360 ◽  
Author(s):  
D. C. Angus ◽  
G. Clermont ◽  
R. S. Watson ◽  
W. T. Linde-Zwirble ◽  
R. H. Clark ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
United States ◽  
Cost Effectiveness ◽  
Respiratory Failure ◽  
The United States ◽  
Inhaled Nitric Oxide

Inhaled nitric oxide as rescue therapy for COVID-19 ARDS unresponsive to prone positioning: a case report

2020 ◽  
Author(s):  
Ricardo Antônio Correia Lima ◽  
Célio Cortinhas Filho ◽  
ricardo lemgruber ◽  
Júlia Falconiere Paredes Ramalho ◽  
Roberto Muniz Ferreira ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Case Report ◽  
Rescue Therapy ◽  
Inhaled Nitric Oxide ◽  
Prone Positioning

Acute Hemodynamic Responses to Inhaled Nitric Oxide in Patients With Limited Scleroderma and Isolated Pulmonary Hypertension

Circulation ◽  
1996 ◽  
Vol 94 (3) ◽  
pp. 477-482 ◽  
Author(s):  
D.J. Williamson ◽  
C. Hayward ◽  
P. Rogers ◽  
L.L. Wallman ◽  
A.D. Sturgess ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Inhaled Nitric Oxide ◽  
Hemodynamic Responses ◽  
Limited Scleroderma

Influence of Inhaled Nitric Oxide on Systemic Flow and Ventricular Filling Pressure in Patients Receiving Mechanical Circulatory Assistance

Circulation ◽  
1997 ◽  
Vol 95 (9) ◽  
pp. 2250-2253 ◽  
Author(s):  
Joshua M. Hare ◽  
Stanton K. Shernan ◽  
Simon C. Body ◽  
Erin Graydon ◽  
Wilson S. Colucci ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Filling Pressure ◽  
Inhaled Nitric Oxide ◽  
Ventricular Filling Pressure ◽  
Ventricular Filling
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