The Protective Effects of Apocynin in Hyperoxic Lung Injury in Neonatal Rats

2021 ◽  
Author(s):  
Ramazan Ozdemir ◽  
Ismail Kursat Gokce ◽  
Suat Tekin ◽  
Aslı Cetin Taslıdere ◽  
Hatice Turgut ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effects ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury

Dexpanthenol therapy reduces lung damage in a hyperoxic lung injury in neonatal rats

2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ramazan Ozdemir ◽  
Gulsum Demirtas ◽  
Hakan Parlakpinar ◽  
Alaadin Polat ◽  
Kevser Tanbag ◽  
...  
Keyword(s):  
Lung Injury ◽  
Lung Damage ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury

scholarly journals Ferroptosis is Involved in Hyperoxic Lung Injury in Neonatal Rats

2021 ◽  
Vol Volume 14 ◽  
pp. 5393-5401
Author(s):  
Danyun Jia ◽  
Jinyu Zheng ◽  
Yiyang Zhou ◽  
Jinqiu Jia ◽  
Xiaoxiao Ye ◽  
...  
Keyword(s):  
Lung Injury ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury

Protective Effects Of Hydrogen Sulphide In Hyperoxic Lung Injury

2011 ◽  
Author(s):  
Sashko G. Spassov ◽  
Simone Faller ◽  
Karl Strosing ◽  
Kornellia Zimmermann ◽  
Alexander Hoetzel
Keyword(s):  
Lung Injury ◽  
Hydrogen Sulphide ◽  
Protective Effects ◽  
Hyperoxic Lung Injury

Azithromycin Protects Against Hyperoxic Lung Injury in Neonatal Rats

2007 ◽  
Vol 55 (6) ◽  
pp. 299-305 ◽  
Author(s):  
Hubert O. Ballard ◽  
Philip Bernard ◽  
Joseph Qualls ◽  
William Everson ◽  
Lori A. Shook
Keyword(s):  
Lung Injury ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury

Beneficial Effect of Etanercept on Hyperoxic Lung Injury Model in Neonatal Rats

2015 ◽  
Vol 29 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Mehmet Yekta Oncel ◽  
Sadik Yurttutan ◽  
Evrim Alyamac Dizdar ◽  
Ismail Kursat Gokce ◽  
Ipek Isik Gonul ◽  
...  
Keyword(s):  
Lung Injury ◽  
Beneficial Effect ◽  
Neonatal Rats ◽  
Injury Model ◽  
Lung Injury Model ◽  
Hyperoxic Lung Injury

scholarly journals 171 RECOMBINANT HUMAN VEGF TREATMENT ENHANCES ALVEOLARIZATION AFTER HYPEROXIC LUNG INJURY IN NEONATAL RATS

2005 ◽  
Vol 53 (1) ◽  
pp. S108.1-S108
Author(s):  
A. Kunig ◽  
V. Balasubramaniam ◽  
N. Markham ◽  
D. Morgan ◽  
G. Montgomery ◽  
...  
Keyword(s):  
Lung Injury ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury

Carbon monoxide provides protection against hyperoxic lung injury

1999 ◽  
Vol 276 (4) ◽  
pp. L688-L694 ◽  
Author(s):  
Leo E. Otterbein ◽  
Lin L. Mantell ◽  
Augustine M. K. Choi
Keyword(s):  
Oxidative Stress ◽  
Carbon Monoxide ◽  
Lung Injury ◽  
Neutrophil Infiltration ◽  
Protein Accumulation ◽  
Protective Effects ◽  
Low Concentration ◽  
Hyperoxic Lung Injury ◽  
Significant Attenuation

Findings in recent years strongly suggest that the stress-inducible gene heme oxygenase (HO)-1 plays an important role in protection against oxidative stress. Although the mechanism(s) by which this protection occurs is poorly understood, we hypothesized that the gaseous molecule carbon monoxide (CO), a major by-product of heme catalysis by HO-1, may provide protection against oxidative stress. We demonstrate here that animals exposed to a low concentration of CO exhibit a marked tolerance to lethal concentrations of hyperoxia in vivo. This increased survival was associated with highly significant attenuation of hyperoxia-induced lung injury as assessed by the volume of pleural effusion, protein accumulation in the airways, and histological analysis. The lungs were completely devoid of lung airway and parenchymal inflammation, fibrin deposition, and pulmonary edema in rats exposed to hyperoxia in the presence of a low concentration of CO. Furthermore, exogenous CO completely protected against hyperoxia-induced lung injury in rats in which endogenous HO enzyme activity was inhibited with tin protoporphyrin, a selective inhibitor of HO. Rats exposed to CO also exhibited a marked attenuation of hyperoxia-induced neutrophil infiltration into the airways and total lung apoptotic index. Taken together, our data demonstrate, for the first time, that CO can be therapeutic against oxidative stress such as hyperoxia and highlight possible mechanism(s) by which CO may mediate these protective effects.

138 ANTI-INFLAMMATORY EFFECTS OF AZITHROMYCIN ON HYPEROXIC LUNG INJURY IN NEONATAL RATS.

2006 ◽  
Vol 54 (1) ◽  
pp. S280.4-S280
Author(s):  
H. O. Ballard ◽  
J. Qualls ◽  
W. Everson ◽  
L. A. Shook
Keyword(s):  
Lung Injury ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury ◽  
Anti Inflammatory

scholarly journals Colchicine Protects against Hyperoxic Lung Injury in Neonatal Rats

Neonatology ◽  
2012 ◽  
Vol 102 (4) ◽  
pp. 265-269 ◽  
Author(s):  
Ramazan Ozdemir ◽  
Sadık Yurttutan ◽  
Beril Talim ◽  
Bülent Uysal ◽  
Omer Erdeve ◽  
...  
Keyword(s):  
Lung Injury ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury
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