Effect of transfer from a paediatric to adult cystic fibrosis centre on clinical status and hospital attendance

2021 ◽  
Author(s):  
Rachel Collins ◽  
Bhajan Singh ◽  
Donald N Payne ◽  
Chrianna Bharat ◽  
William Noffsinger ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Clinical Status ◽  
Cystic Fibrosis Centre

scholarly journals Inflammation in children with cystic fibrosis: contribution of bacterial production of long-chain fatty acids

2021 ◽  
Author(s):  
Erin Felton ◽  
Aszia Burrell ◽  
Hollis Chaney ◽  
Iman Sami ◽  
Anastassios C. Koumbourlis ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Fatty Acid ◽  
Antibiotic Treatment ◽  
Bacterial Production ◽  
Clinical Status ◽  
Achromobacter Xylosoxidans ◽  
List Type ◽  
Future Studies ◽  
Long Chain

Abstract Background Cystic fibrosis (CF) affects >70,000 people worldwide, yet the microbiologic trigger for pulmonary exacerbations (PExs) remains unknown. The objective of this study was to identify changes in bacterial metabolic pathways associated with clinical status. Methods Respiratory samples were collected at hospital admission for PEx, end of intravenous (IV) antibiotic treatment, and follow-up from 27 hospitalized children with CF. Bacterial DNA was extracted and shotgun DNA sequencing was performed. MetaPhlAn2 and HUMAnN2 were used to evaluate bacterial taxonomic and pathway relative abundance, while DESeq2 was used to evaluate differential abundance based on clinical status. Results The mean age of study participants was 10 years; 85% received combination IV antibiotic therapy (beta-lactam plus a second agent). Long-chain fatty acid (LCFA) biosynthesis pathways were upregulated in follow-up samples compared to end of treatment: gondoate (p = 0.012), oleate (p = 0.048), palmitoleate (p = 0.043), and pathways of fatty acid elongation (p = 0.012). Achromobacter xylosoxidans and Escherichia sp. were also more prevalent in follow-up compared to PEx (p < 0.001). Conclusions LCFAs may be associated with persistent infection of opportunistic pathogens. Future studies should more closely investigate the role of LCFA production by lung bacteria in the transition from baseline wellness to PEx in persons with CF. Impact Increased levels of LCFAs are found after IV antibiotic treatment in persons with CF. LCFAs have previously been associated with increased lung inflammation in asthma. This is the first report of LCFAs in the airway of persons with CF. This research provides support that bacterial production of LCFAs may be a contributor to inflammation in persons with CF. Future studies should evaluate LCFAs as predictors of future PExs.

scholarly journals P091 Regularity of check-ups at the cystic fibrosis centre in the time of COVID-19 pandemic

2021 ◽  
Vol 20 ◽  
pp. S67
Author(s):  
I. Todorić ◽  
I. Bambir ◽  
I. Markelić ◽  
L. Omerza ◽  
T. Milinković ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Cystic Fibrosis Centre

scholarly journals EPS1.06 A retrospective audit of home-based spirometry quality in a large UK adult cystic fibrosis centre

2021 ◽  
Vol 20 ◽  
pp. S30-S31
Author(s):  
I. Waller ◽  
J. Daulby ◽  
H. Langman ◽  
V. Yarwood ◽  
J. Mitchell ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Retrospective Audit ◽  
Home Based ◽  
Cystic Fibrosis Centre

P070 Epidemiology of nontuberculous mycobacteria in a single adult cystic fibrosis centre

2021 ◽  
Vol 20 ◽  
pp. S60
Author(s):  
A. Kumar ◽  
D. Wat ◽  
S. Hameed ◽  
C. Baker ◽  
D. Nazareth ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Nontuberculous Mycobacteria ◽  
Cystic Fibrosis Centre
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