A randomized single‐center controlled trial of synchronized intermittent mandatory ventilation with heliox in newborn infants with meconium aspiration syndrome

2021 ◽  
Author(s):  
Juan Ma ◽  
Shifang Tang ◽  
Leilei Shen ◽  
Long Chen ◽  
Xue Li ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Newborn Infants ◽  
Meconium Aspiration Syndrome ◽  
Single Center ◽  
Intermittent Mandatory Ventilation ◽  
Meconium Aspiration

An Investigation of the Mortality Rate and Risk Factors in Newborn Infants With Meconium Aspiration Syndrome

2016 ◽  
Vol 7 (3) ◽  
Author(s):  
Mohammad Kazem Sabzehei ◽  
Behnaz Basiri ◽  
Maryam Shokouhi ◽  
Mohammad Hossein Eslamian ◽  
Zahra Razavi
Keyword(s):  
Risk Factors ◽  
Mortality Rate ◽  
Newborn Infants ◽  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration

Coproporphyrin in urine of newborns with meconium aspiration syndrome.

1983 ◽  
Vol 29 (12) ◽  
pp. 2054-2056 ◽  
Author(s):  
J Francoual ◽  
A Lindenbaum ◽  
M Dehan ◽  
H de Verneuil ◽  
Y Nordmann ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Thin Layer ◽  
High Performance ◽  
Newborn Infants ◽  
Meconium Aspiration Syndrome ◽  
Spectrophotometric Analysis ◽  
Partial Purification ◽  
Meconium Aspiration ◽  
Urinary Coproporphyrin

Abstract We evaluated coproporphyrin in the first urine passed by newborn infants with and without meconium aspiration, by spectrophotometric analysis and thin-layer and "high-performance" liquid chromatography. Urines of newborn infants without meconium aspiration contained only very small quantities of coproporphyrin, detected, after partial purification, by "high-performance" liquid chromatography. Urines of newborn infants with meconium aspiration contained large quantities of coproporphyrin, identified by all three techniques. Urinary coproporphyrin as measured spectrophotometrically correlates well with the "urinary meconium index," and the method is simple, rapid, and reliable, even for samples containing hemoglobin.

Lung Lavage with Dilute Surfactant vs. Bolus Surfactant for Meconium Aspiration Syndrome

2019 ◽  
Vol 65 (5) ◽  
pp. 491-497 ◽  
Author(s):  
Sema Arayici ◽  
Fatma Nur Sari ◽  
Gulsum Kadioglu Simsek ◽  
Erbu Yarci ◽  
Evrim Alyamac Dizdar ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Lung Lavage ◽  
Meconium Aspiration Syndrome ◽  
Respiratory Support ◽  
High Frequency Ventilation ◽  
Clinical Trial Registration ◽  
Meconium Aspiration ◽  
Randomized Controlled ◽  
Frequency Ventilation ◽  
Respiratory Outcomes

Abstract Objective To compare the effectiveness of lung lavage with surfactant vs. bolus surfactant treatment in meconium aspiration syndrome (MAS). Patients and methods This randomized controlled trial included newborns ventilated with MAS. In lavage group (n = 17) 30 ml/kg of diluted porcine surfactant was instilled into the lung. In bolus group (n = 16) porcine surfactant (100 mg/kg) was administered as bolus. Respiratory outcomes and mortality were compared between groups. Results Duration of respiratory support was found to be similar between lavage and bolus groups (3 vs. 3.5 days, p = 0.36). Death or requirement for extracorporeal membrane oxygenation (ECMO) was 12% vs. 6%; respectively (RR: 2, 95% CI 0.16–24.48; p = 1.0). Duration of oxygen therapy, high-frequency ventilation or inhaled nitric oxide requirement did not differ among the groups. Conclusion Lung lavage did not show any advantage over bolus therapy on duration of respiratory support. The incidence of pneumothorax and surfactant re-administration decreased nonsignificantly in lavage group. Clinical Trial Registration We registered the trial to ClinicalTrials.gov (http://clinicaltrials.gov) under identifier NCT02041546. Registry name Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome.

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