scholarly journals Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure

2020 ◽  
Vol 55 (10) ◽  
pp. 2730-2736
Author(s):  
Shan L. Ward ◽  
Mary K. Dahmer ◽  
Heidi M. Weeks ◽  
Anil Sapru ◽  
Michael W. Quasney ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Weight Status ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Epithelial Injury ◽  
Alveolar Epithelial ◽  
Alveolar Epithelial Injury ◽  
Patient Weight

scholarly journals Surfactant Protein B Deficiency Induced High Surface Tension: Relationship between Alveolar Micromechanics, Alveolar Fluid Properties and Alveolar Epithelial Cell Injury

2019 ◽  
Vol 20 (17) ◽  
pp. 4243 ◽  
Author(s):  
Nina Rühl ◽  
Elena Lopez-Rodriguez ◽  
Karolin Albert ◽  
Bradford J Smith ◽  
Timothy E Weaver ◽  
...  
Keyword(s):  
Surface Tension ◽  
Lung Injury ◽  
High Surface ◽  
Surfactant Protein ◽  
Epithelial Injury ◽  
High Surface Tension ◽  
Alveolar Epithelial ◽  
Surfactant Protein B ◽  
Fluid Properties ◽  
Alveolar Epithelial Injury

High surface tension at the alveolar air-liquid interface is a typical feature of acute and chronic lung injury. However, the manner in which high surface tension contributes to lung injury is not well understood. This study investigated the relationship between abnormal alveolar micromechanics, alveolar epithelial injury, intra-alveolar fluid properties and remodeling in the conditional surfactant protein B (SP-B) knockout mouse model. Measurements of pulmonary mechanics, broncho-alveolar lavage fluid (BAL), and design-based stereology were performed as a function of time of SP-B deficiency. After one day of SP-B deficiency the volume of alveolar fluid V(alvfluid,par) as well as BAL protein and albumin levels were normal while the surface area of injured alveolar epithelium S(AEinjure,sep) was significantly increased. Alveoli and alveolar surface area could be recruited by increasing the air inflation pressure. Quasi-static pressure-volume loops were characterized by an increased hysteresis while the inspiratory capacity was reduced. After 3 days, an increase in V(alvfluid,par) as well as BAL protein and albumin levels were linked with a failure of both alveolar recruitment and airway pressure-dependent redistribution of alveolar fluid. Over time, V(alvfluid,par) increased exponentially with S(AEinjure,sep). In conclusion, high surface tension induces alveolar epithelial injury prior to edema formation. After passing a threshold, epithelial injury results in vascular leakage and exponential accumulation of alveolar fluid critically hampering alveolar recruitability.

scholarly journals Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure

CHEST Journal ◽  
2020 ◽  
Vol 158 (3) ◽  
pp. 1027-1035 ◽  
Author(s):  
Mary K. Dahmer ◽  
Heidi Flori ◽  
Anil Sapru ◽  
Joseph Kohne ◽  
Heidi M. Weeks ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Prolonged Ventilation

Detection of alveolar epithelial injury by Tc-99m DTPA radioaerosol inhalation lung scan in rheumatoid arthritis patients

2005 ◽  
Vol 19 (6) ◽  
pp. 455-460 ◽  
Author(s):  
Berna Okudan ◽  
Mehmet Şahİn ◽  
Feride Meltem Özbek ◽  
Ali Ümit Keskİn ◽  
Erkan Cüre
Keyword(s):  
Rheumatoid Arthritis ◽  
Epithelial Injury ◽  
Alveolar Epithelial ◽  
Lung Scan ◽  
Alveolar Epithelial Injury

Alveolar Epithelial Injury Causing Respiratory Distress in Dogs

CHEST Journal ◽  
1979 ◽  
Vol 75 (6) ◽  
pp. 705-711 ◽  
Author(s):  
C. Redington Barrett ◽  
A.L. Loomis Bell ◽  
Stephen F. Ryan
Keyword(s):  
Respiratory Distress ◽  
Epithelial Injury ◽  
Alveolar Epithelial ◽  
Alveolar Epithelial Injury

scholarly journals Differential alveolar epithelial injury and protein expression in pneumococcal pneumonia

2012 ◽  
Vol 38 (5) ◽  
pp. 266-276 ◽  
Author(s):  
Christine Tyrrell ◽  
Stuart R. McKechnie ◽  
Michael F. Beers ◽  
Tim J. Mitchell ◽  
Mary C. McElroy
Keyword(s):  
Protein Expression ◽  
Pneumococcal Pneumonia ◽  
Epithelial Injury ◽  
Alveolar Epithelial ◽  
Alveolar Epithelial Injury

scholarly journals Analyses of alveolar epithelial injury via lipid-related stress in mammalian target of rapamycin inhibitor-induced lung disease

2019 ◽  
Vol 99 (6) ◽  
pp. 853-865
Author(s):  
Nariaki Kokuho ◽  
Yasuhiro Terasaki ◽  
Shinobu Kunugi ◽  
Yoshinobu Saito ◽  
Hirokazu Urushiyama ◽  
...  
Keyword(s):  
Lung Disease ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Epithelial Injury ◽  
Alveolar Epithelial ◽  
Alveolar Epithelial Injury ◽  
Related Stress
Sign in / Sign up

Export Citation Format

Share Document