The bridging bronchus: A comprehensive review of a rare, potentially life‐threatening congenital airway anomaly associated with cardiovascular defects

2019 ◽  
Vol 54 (12) ◽  
pp. 1895-1904
Author(s):  
Brandon M. Henry ◽  
Isaac Cheruiyot ◽  
Linda M. Wong ◽  
Kerri Keet ◽  
Victor Mutua ◽  
...  
Keyword(s):  
Comprehensive Review ◽  
Cardiovascular Defects ◽  
Bridging Bronchus ◽  
Life Threatening ◽  
Airway Anomaly

scholarly journals Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease

2021 ◽  
Vol 9 ◽  
Author(s):  
Rui Gao ◽  
Jie Ren
Keyword(s):  
Molecular Mechanisms ◽  
Atrioventricular Node ◽  
Conduction System ◽  
Cardiac Conduction ◽  
External Fertilization ◽  
Evolutionarily Conserved ◽  
Cardiovascular Defects ◽  
Vertebrate Model ◽  
Life Threatening ◽  
Therapeutic Research

Malfunction in the cardiac conduction system (CCS) due to congenital anomalies or diseases can cause cardiac conduction disease (CCD), which results in disturbances in cardiac rhythm, leading to syncope and even sudden cardiac death. Insights into development of the CCS components, including pacemaker cardiomyocytes (CMs), atrioventricular node (AVN) and the ventricular conduction system (VCS), can shed light on the pathological and molecular mechanisms underlying CCD, provide approaches for generating human pluripotent stem cell (hPSC)-derived CCS cells, and thus improve therapeutic treatment for such a potentially life-threatening disorder of the heart. However, the cellular and molecular mechanisms controlling CCS development remain elusive. The zebrafish has become a valuable vertebrate model to investigate early development of CCS components because of its unique features such as external fertilization, embryonic optical transparency and the ability to survive even with severe cardiovascular defects during development. In this review, we highlight how the zebrafish has been utilized to dissect the cellular and molecular mechanisms of CCS development, and how the evolutionarily conserved developmental mechanisms discovered in zebrafish could be applied to directing the creation of hPSC-derived CCS cells, therefore providing potential therapeutic strategies that may contribute to better treatment for CCD patients.

scholarly journals Rhabdomyolysis Induced by Coadministration of Fusidic Acid and Atorvastatin: A Case Report and Comprehensive Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Dimitrios Patoulias ◽  
Theodoros Michailidis ◽  
Thomas Papatolios ◽  
Rafael Papadopoulos ◽  
Petros Keryttopoulos
Keyword(s):  
Emergency Department ◽  
Fusidic Acid ◽  
Direct Consequence ◽  
Review Of The Literature ◽  
Limb Weakness ◽  
Comprehensive Review ◽  
Acute Rhabdomyolysis ◽  
Life Threatening ◽  
History Of ◽  
Life Threatening Complication

Statins are among the most widely prescribed medications worldwide. Acute rhabdomyolysis constitutes a potentially life-threatening side effect regardless of whether statins are administered alone or in combination. The potentially fatal combination of a statin and fusidic acid has been well described in the literature. Acute renal failure can be a direct consequence of this drug-drug interaction. We present a case of a 79-year-old woman who presented to our Emergency Department with a one-week history of limb weakness, myalgia, and inability to stand and walk. The patient had been given fusidic acid to treat Methicillin-Sensitive Staphylococcus Aureus (MSSA) positive dermatitis in the 3 weeks prior to admission, while she continued to take her complete therapeutic regimen, which included atorvastatin. Thus, she developed rhabdomyolysis due to the interaction between fusidic acid and atorvastatin. Herein, we report a life-threatening complication of coadministration of fusidic acid and a statin, which is preventable and predictable. The exact mechanism of the interaction is not fully understood, but coadministration of these two medications must be avoided in clinical practice.

Pneumatosis From Esophagus to Rectum: A Comprehensive Review Focusing on Clinico-Radiological Differentiation Between Benign and Life-Threatening Causes

2018 ◽  
Vol 39 (2) ◽  
pp. 167-182 ◽  
Author(s):  
Ulysses S. Torres ◽  
Camila D.F.M. Fortes ◽  
Priscila S. Salvadori ◽  
Dario A. Tiferes ◽  
Giuseppe D′Ippolito
Keyword(s):  
Comprehensive Review ◽  
Life Threatening

scholarly journals Stenotic bridging bronchus: An uncommon congenital airway anomaly

Lung India ◽  
2021 ◽  
Vol 38 (4) ◽  
pp. 399
Author(s):  
Anmol Bhatia ◽  
S Raghuraman ◽  
KushaljitSingh Sodhi ◽  
JosephL Mathew ◽  
AkshayKumar Saxena
Keyword(s):  
Bridging Bronchus ◽  
Airway Anomaly

scholarly journals Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases

2021 ◽  
Vol 22 (20) ◽  
pp. 11290
Author(s):  
Mahmoud Youssef ◽  
Hanaa Y. Ahmed ◽  
Abel Zongo ◽  
Ali Korin ◽  
Fuchao Zhan ◽  
...  
Keyword(s):  
Essential Role ◽  
Functional Foods ◽  
Viral Infections ◽  
Human Life ◽  
Allergic Diseases ◽  
Immune Disorders ◽  
Close Attention ◽  
Comprehensive Review ◽  
Life Threatening ◽  
Promising Solution

Chronic diseases and viral infections have threatened human life over the ages and constitute the main reason for increasing death globally. The rising burden of these diseases extends to negatively affecting the economy and trading globally, as well as daily life, which requires inexpensive, novel, and safe therapeutics. Therefore, scientists have paid close attention to probiotics as safe remedies to combat these morbidities owing to their health benefits and biotherapeutic effects. Probiotics have been broadly adopted as functional foods, nutraceuticals, and food supplements to improve human health and prevent some morbidity. Intriguingly, recent research indicates that probiotics are a promising solution for treating and prophylactic against certain dangerous diseases. Probiotics could also be associated with their essential role in animating the immune system to fight COVID-19 infection. This comprehensive review concentrates on the newest literature on probiotics and their metabolism in treating life-threatening diseases, including immune disorders, pathogens, inflammatory and allergic diseases, cancer, cardiovascular disease, gastrointestinal dysfunctions, and COVID-19 infection. The recent information in this report will particularly furnish a platform for emerging novel probiotics-based therapeutics as cheap and safe, encouraging researchers and stakeholders to develop innovative treatments based on probiotics to prevent and treat chronic and viral diseases.

Bronchial and Nonbronchial Systemic Artery Embolization for Life-threatening Hemoptysis: A Comprehensive Review

Radiographics ◽  
2002 ◽  
Vol 22 (6) ◽  
pp. 1395-1409 ◽  
Author(s):  
Woong Yoon ◽  
Jae Kyu Kim ◽  
Yun Hyun Kim ◽  
Tae Woong Chung ◽  
Heoung Keun Kang
Keyword(s):  
Artery Embolization ◽  
Comprehensive Review ◽  
Systemic Artery ◽  
Life Threatening

Bridging bronchus: a rare airway anomaly.

Radiology ◽  
1981 ◽  
Vol 140 (1) ◽  
pp. 95-96 ◽  
Author(s):  
R J Starshak ◽  
J R Sty ◽  
G Woods ◽  
F V Kreitzer
Keyword(s):  
Bridging Bronchus ◽  
Airway Anomaly

scholarly journals Magnesium: The Forgotten Electrolyte—A Review on Hypomagnesemia

2019 ◽  
Vol 7 (4) ◽  
pp. 56 ◽  
Author(s):  
Faheemuddin Ahmed ◽  
Abdul Mohammed
Keyword(s):  
Clinical Practice ◽  
General Population ◽  
Medical Literature ◽  
Clinical Manifestations ◽  
The Body ◽  
Sodium Potassium ◽  
Comprehensive Review ◽  
Organ Systems ◽  
Life Threatening

Magnesium is the fourth most abundant cation in the body and the second most abundant intracellular cation. It plays an important role in different organ systems at the cellular and enzymatic levels. Despite its importance, it still has not received the needed attention either in the medical literature or in clinical practice in comparison to other electrolytes like sodium, potassium, and calcium. Hypomagnesemia can lead to many clinical manifestations with some being life-threatening. The reported incidence is less likely than expected in the general population. We present a comprehensive review of different aspects of magnesium physiology and hypomagnesemia which can help clinicians in understanding, identifying, and treating this disorder.

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