Oxygen saturation/FIO2 ratio at 36 weeks’ PMA in 1005 preterm infants: Effect of gestational age and early respiratory disease patterns

2019 ◽  
Vol 54 (5) ◽  
pp. 637-643 ◽  
Author(s):  
Stefano Nobile ◽  
Paolo Marchionni ◽  
Carlo Gidiucci ◽  
Alessio Correani ◽  
Maria L. Palazzi ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Respiratory Disease ◽  
Preterm Infants ◽  
Gestational Age ◽  
Disease Patterns

scholarly journals 10 Mean Cerebral Oxygen Saturation Increases with Gestational Age in Preterm Infants

2004 ◽  
Vol 56 (3) ◽  
pp. 465-465
Author(s):  
T Austin ◽  
J Henty ◽  
J H Meek ◽  
C E Elwell ◽  
J S Wyatt
Keyword(s):  
Oxygen Saturation ◽  
Preterm Infants ◽  
Gestational Age ◽  
Cerebral Oxygen Saturation ◽  
Cerebral Oxygen

scholarly journals Impact of Carbon Dioxide on Cerebral Oxygenation and Vital Parameters in Stable Preterm and Term Infants Immediately after Birth

Neonatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Christina Helene Wolfsberger ◽  
Marlies Bruckner ◽  
Bernhard Schwaberger ◽  
Lukas Peter Mileder ◽  
Berndt Urlesberger ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Saturation ◽  
Preterm Infants ◽  
Gestational Age ◽  
Oxygen Extraction ◽  
Arterial Oxygen ◽  
Secondary Outcome ◽  
Tissue Oxygen ◽  
Term Infants ◽  
The Impact

<b><i>Introduction:</i></b> Carbon dioxide (pCO<sub>2</sub>) induces changes in the tone of cerebral vessels. The aim of the present study was to evaluate the impact of pCO<sub>2</sub> on cerebral regional tissue oxygen saturation (crSO<sub>2</sub>), cerebral fractional tissue oxygen extraction (cFTOE), and cerebral tissue oxygen extraction (cTOE), measured with near-infrared spectroscopy (NIRS), in preterm and term infants 15 min after birth. <b><i>Methods:</i></b> Post hoc analyses of secondary outcome parameters of prospective observational studies were performed. Stable preterm and term infants with cerebral NIRS monitoring (INVOS 5100C) until minute 15 after birth and a blood gas analysis, performed between minutes 14–18 after birth, were included. Heart rate (HR) and arterial oxygen saturation (SpO<sub>2</sub>) were recorded. pCO<sub>2</sub> was correlated with crSO<sub>2</sub>, cFTOE, cTOE, SpO<sub>2</sub>, HR, and partial pressure of oxygen (pO<sub>2</sub>). <b><i>Results:</i></b> Eleven preterm infants with a median (IQR) gestational age of 34.8 (32.7–36.1) weeks were analyzed. Mean ± SD pCO<sub>2</sub> was 53.5 ± 4.2 mm Hg. At minute 15 after birth, crSO<sub>2</sub> was 82.6 (74.3–91.3)%, cFTOE 0.15 ± 0.09, cTOE 14.6 ± 8.4%, SpO<sub>2</sub> 97.4 ± 2.1%, and HR 152 (136–167) bpm. pCO<sub>2</sub> correlated negatively with crSO<sub>2</sub> (<i>p</i> = 0.012) and positively with cFTOE (<i>p</i> = 0.035) and cTOE (<i>p</i> = 0.037). Eighty-four term infants with a gestational age of 39.0 (38.5–38.9) weeks were analyzed. pCO<sub>2</sub> was 53.5 ± 6.3 mm Hg. At minute 15 after birth, crSO<sub>2</sub> was 84.4 (80.8–85.1)%, cFTOE 0.14 ± 0.08, cTOE 13.6 ± 7.9%, SpO<sub>2</sub> 96.5 ± 2.6%, and HR 155 (153–163) bpm. pCO<sub>2</sub> did only negatively correlate with pO<sub>2</sub> (<i>p</i> = 0.034) in term infants. <b><i>Conclusion:</i></b> In preterm infants, higher pCO<sub>2</sub> was associated with lower crSO<sub>2</sub> and higher cFTOE/cTOE. In term infants, no associations were observed. The present findings suggest that the vasodilatative effect of pCO<sub>2</sub> is less pronounced in preterm infants during immediate postnatal transition.

Lower oxygen saturation targets in preterm infants are not associated with increased rates of pulmonary hypertension

2021 ◽  
pp. 1-8
Author(s):  
M. Niccum ◽  
F. Spyropoulos ◽  
J.C. Levin ◽  
C.R. Petty ◽  
M.P. Mullen ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Birth Weight ◽  
Oxygen Saturation ◽  
Preterm Infants ◽  
Gestational Age ◽  
Retrospective Cohort ◽  
Chi Square ◽  
Average Birth Weight ◽  
Lower Oxygen ◽  
Chi Square Test

BACKGROUND: The optimal oxygen saturation target in preterm infants is not known. In this study, we aimed to assess the effect of lower oxygen saturation targets on the rate of bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), and pulmonary hypertension (PH) in preterm infants. METHODS: Retrospective cohort study comparing BPD, ROP, and PH incidence among two cohorts of infants born at≤32 weeks gestation with different oxygen saturation targets at≥34 weeks post-menstrual age (PMA): cohort 1, 94–98% (n = 126); cohort 2, 92–97% (n = 121). Groups compared by Chi-square test, t-test, and multivariable logistic regression. RESULTS: When comparing cohort 1 (average gestational age 29.8 weeks, average birth weight 1271g) with cohort 2 (average gestational age 29.6 weeks, average birth weight 1299g), there was no difference in rate of BPD (24% vs. 19%, p = 0.38), ROP (4% vs. 3%, p = 0.49), or PH (2% vs. 4%, p = 0.44). CONCLUSION: An oxygen saturation target of 92–97% at≥34 weeks PMA was not associated with a higher rate of PH or lower rate of BPD or ROP when compared with a higher target of 94–98%.

scholarly journals The effect of automated oxygen control on clinical outcomes in preterm infants: a pre- and post-implementation cohort study

2021 ◽  
Author(s):  
H. H. Salverda ◽  
N. J. Oldenburger ◽  
M. Rijken ◽  
S. C. Pauws ◽  
P. A. Dargaville ◽  
...  
Keyword(s):  
Cohort Study ◽  
Length Of Stay ◽  
Oxygen Saturation ◽  
Preterm Infants ◽  
Gestational Age ◽  
Standard Of Care ◽  
Target Range ◽  
Invasive Ventilation ◽  
Oxygen Control ◽  
Automated Oxygen Control

AbstractSeveral studies demonstrated an increase in time spent within target range when automated oxygen control (AOC) is used. However the effect on clinical outcome remains unclear. We compared clinical outcomes of preterm infants born before and after implementation of AOC as standard of care. In a retrospective pre-post implementation cohort study of outcomes for infants of 24–29 weeks gestational age receiving respiratory support before (2012–2015) and after (2015–2018) implementation of AOC as standard of care were compared. Outcomes of interest were mortality and complications of prematurity, number of ventilation days, and length of stay in the Neonatal Intensive Care Unit (NICU). A total of 588 infants were included (293 pre- vs 295 in the post-implementation cohort), with similar gestational age (27.8 weeks pre- vs 27.6 weeks post-implementation), birth weight (1033 grams vs 1035 grams) and other baseline characteristics. Mortality and rate of prematurity complications were not different between the groups. Length of stay in NICU was not different, but duration of invasive ventilation was shorter in infants who received AOC (6.4 ± 10.1 vs 4.7 ± 8.3, p = 0.029).Conclusion: In this pre-post comparison, the implementation of AOC did not lead to a change in mortality or morbidity during admission. What is Known:• Prolonged and intermittent oxygen saturation deviations are associated with mortality and prematurity-related morbidities.• Automated oxygen controllers can increase the time spent within oxygen saturation target range.What is New:• Implementation of automated oxygen control as standard of care did not lead to a change in mortality or morbidity during admission.• In the period after implementation of automated oxygen control, there was a shift toward more non-invasive ventilation.

Behaviour at 2 years of age in very preterm infants (gestational age <32 weeks)

2003 ◽  
Vol 92 (5) ◽  
pp. 1-1 ◽  
Author(s):  
GMSJ Stoelhorst ◽  
SE Martens ◽  
M Rijken ◽  
van Zwieten PHT ◽  
AH Zwinderman ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Very Preterm Infants ◽  
Very Preterm
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