Carbon dioxide washout during high flow nasal cannula versus nasal CPAP support: An in vitro study

2017 ◽  
Vol 52 (6) ◽  
pp. 792-798 ◽  
Author(s):  
Emidio M. Sivieri ◽  
Elizabeth E. Foglia ◽  
Soraya Abbasi
Keyword(s):  
Carbon Dioxide ◽  
In Vitro Study ◽  
High Flow ◽  
Nasal Cannula ◽  
Vitro Study ◽  
High Flow Nasal Cannula ◽  
Nasal Cpap

Noise Levels of Neonatal High-Flow Nasal Cannula Devices - An in-vitro Study

Neonatology ◽  
2013 ◽  
Vol 103 (4) ◽  
pp. 264-267 ◽  
Author(s):  
Kai König ◽  
Ellen L. Stock ◽  
Melanie Jarvis
Keyword(s):  
In Vitro Study ◽  
High Flow ◽  
Nasal Cannula ◽  
Vitro Study ◽  
Noise Levels ◽  
High Flow Nasal Cannula

scholarly journals Optimizing high-flow nasal cannula flow settings in adult hypoxemic patients based on peak inspiratory flow during tidal breathing

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jie Li ◽  
J. Brady Scott ◽  
James B. Fink ◽  
Brooke Reed ◽  
Oriol Roca ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Inspiratory Flow ◽  
High Flow ◽  
Nasal Cannula ◽  
Vitro Study ◽  
Patient Comfort ◽  
High Flow Nasal Cannula ◽  
Optimal Flow ◽  
The Individual

Abstract Background Optimal flow settings during high-flow nasal cannula (HFNC) therapy are unknown. We investigated the optimal flow settings during HFNC therapy based on breathing pattern and tidal inspiratory flows in patients with acute hypoxemic respiratory failure (AHRF). Methods We conducted a prospective clinical study in adult hypoxemic patients treated by HFNC with a fraction of inspired oxygen (FIO2) ≥ 0.4. Patient’s peak tidal inspiratory flow (PTIF) was measured and HFNC flows were set to match individual PTIF and then increased by 10 L/min every 5–10 min up to 60 L/min. FIO2 was titrated to maintain pulse oximetry (SpO2) of 90–97%. SpO2/FIO2, respiratory rate (RR), ROX index [(SpO2/FIO2)/RR], and patient comfort were recorded after 5–10 min on each setting. We also conducted an in vitro study to explore the relationship between the HFNC flows and the tracheal FIO2, peak inspiratory and expiratory pressures. Results Forty-nine patients aged 58.0 (SD 14.1) years were enrolled. At enrollment, HFNC flow was set at 45 (38, 50) L/min, with an FIO2 at 0.62 (0.16) to obtain an SpO2/FIO2 of 160 (40). Mean PTIF was 34 (9) L/min. An increase in HFNC flows up to two times of the individual patient’s PTIF, incrementally improved oxygenation but the ROX index plateaued with HFNC flows of 1.34–1.67 times the individual PTIF. In the in vitro study, when the HFNC flow was set higher than PTIF, tracheal peak inspiratory and expiratory pressures increased as HFNC flow increased but the FIO2 did not change. Conclusion Mean PTIF values in most patients with AHRF were between 30 and 40 L/min. We observed improvement in oxygenation with HFNC flows set above patient PTIF. Thus, a pragmatic approach to set optimal flows in patients with AHRF would be to initiate HFNC flow at 40 L/min and titrate the flow based on improvement in ROX index and patient tolerance. Trial registration: ClinicalTrials.gov (NCT03738345). Registered on November 13th, 2018. https://clinicaltrials.gov/ct2/show/NCT03738345?term=NCT03738345&draw=2&rank=1

In vitro evaluation of aerosol drug delivery with and without high flow nasal cannula in children

2019 ◽  
Vol 54 (12) ◽  
pp. 1968-1973 ◽  
Author(s):  
Mahmood A. Alalwan ◽  
James B. Fink ◽  
Arzu Ari
Keyword(s):  
Drug Delivery ◽  
High Flow ◽  
Nasal Cannula ◽  
High Flow Nasal Cannula ◽  
In Vitro Evaluation

IN VITRO AND IN VIVO EVALUATION OF A NEONATAL HIGH-FLOW NASAL CANNULA SYSTEM.

2007 ◽  
Vol 55 (1) ◽  
pp. S97
Author(s):  
A. L. Lampland ◽  
P. A. Meyers ◽  
C. T. Worwa ◽  
B. J. Plumm ◽  
M. C. Mammel
Keyword(s):  
High Flow ◽  
Nasal Cannula ◽  
High Flow Nasal Cannula ◽  
In Vivo Evaluation

scholarly journals In Vitro Study of the Effect of Breathing Pattern on Aerosol Delivery During High-Flow Nasal Therapy

2019 ◽  
Vol 5 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Gavin Bennett ◽  
Mary Joyce ◽  
Louise Sweeney ◽  
Ronan MacLoughlin
Keyword(s):  
Breathing Pattern ◽  
In Vitro Study ◽  
High Flow ◽  
Vitro Study ◽  
Aerosol Delivery
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