scholarly journals Oligohydramnios compromises lung cells size and interferes with epithelial-endothelial development

2017 ◽  
Vol 52 (6) ◽  
pp. 746-756 ◽  
Author(s):  
Tanbir Najrana ◽  
Lauren M. Ramos ◽  
Rasha Abu Eid ◽  
Juan Sanchez-Esteban
Keyword(s):  
Lung Cells ◽  
Endothelial Development

Ciliary coordination in newt lung cells requires microtubule-based linkages between basal bodies: A correlative light and EM study

1992 ◽  
Vol 50 (1) ◽  
pp. 570-571
Author(s):  
Robert Hard ◽  
Gerald Rupp ◽  
Matthew L. Withiam-Leitch ◽  
Lisa Cardamone
Keyword(s):  
Basal Body ◽  
Untreated Control ◽  
Beat Frequency ◽  
Primary Cultures ◽  
Living Cells ◽  
Power Stroke ◽  
Ultrastructural Changes ◽  
Lung Cells ◽  
Basal Bodies ◽  
Ciliated Cells

In a coordinated field of beating cilia, the direction of the power stroke is correlated with the orientation of basal body appendages, called basal feet. In newt lung ciliated cells, adjacent basal feet are interconnected by cold-stable microtubules (basal MTs). In the present study, we investigate the hypothesis that these basal MTs stabilize ciliary distribution and alignment. To accomplish this, newt lung primary cultures were treated with the microtubule disrupting agent, Colcemid. In newt lung cultures, cilia normally disperse in a characteristic fashion as the mucociliary epithelium migrates from the tissue explant. Four arbitrary, but progressive stages of dispersion were defined and used to monitor this redistribution process. Ciliaiy beat frequency, coordination, and dispersion were assessed for 91 hrs in untreated (control) and treated cultures. When compared to controls, cilia dispersed more rapidly and ciliary coordination decreased markedly in cultures treated with Colcemid (2 mM). Correlative LM/EM was used to assess whether these effects of Colcemid were coupled to ultrastructural changes. Living cells were defined as having coordinated or uncoordinated cilia and then were processed for transmission EM.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Induction of Apoptosis by Gamma-Irradiated Apigenin in H1975 Human Non-Small Lung Cells

2015 ◽  
Vol 44 (6) ◽  
pp. 816-822 ◽  
Author(s):  
Jae-Nam Park ◽  
Eui-Baek Byun ◽  
Jwa-Jin Kim ◽  
Beon-Su Jang ◽  
Sang-Hyun Park
Keyword(s):  
Lung Cells ◽  
Induction Of Apoptosis ◽  
Gamma Irradiated

The Impact of 5-Substituted Uracil Derivatives on Immortalized Embryo Lung Cells

2017 ◽  
Vol 14 (12) ◽  
Author(s):  
Natalia N. Kabal'nova ◽  
Stanislav A. Grabovskiy ◽  
Nadezhda M. Andriayshina ◽  
Vladislav I. Egorov ◽  
Lenar R. Valiullin ◽  
...  
Keyword(s):  
Lung Cells ◽  
Uracil Derivatives ◽  
The Impact
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