Influenza a (H1N1) virus pneumonia in newborns: experience of a referral level iii neonatal intensive care unit in turkey

2010 ◽  
Vol 46 (2) ◽  
pp. 201-202 ◽  
Author(s):  
Gozde Kanmaz ◽  
Omer Erdeve ◽  
Serife Suna Oguz ◽  
Nurdan Uras ◽  
Ugur Dilmen
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Influenza A ◽  
Neonatal Intensive Care ◽  
H1n1 Virus ◽  
Influenza A H1n1 ◽  
Virus Pneumonia

Influenza A/H1N1/2009 outbreak in a neonatal intensive care unit

2012 ◽  
Vol 81 (1) ◽  
pp. 36-40 ◽  
Author(s):  
V. Tsagris ◽  
A. Nika ◽  
D. Kyriakou ◽  
I. Kapetanakis ◽  
E. Harahousou ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Influenza A ◽  
Neonatal Intensive Care ◽  
Influenza A H1n1

scholarly journals Oseltamivir Pharmacokinetics and Clinical Experience in Neonates and Infants during an Outbreak of H1N1 Influenza A Virus Infection in a Neonatal Intensive Care Unit

2012 ◽  
Vol 56 (7) ◽  
pp. 3833-3840 ◽  
Author(s):  
Joseph F. Standing ◽  
Angela Nika ◽  
Vasileios Tsagris ◽  
Ioannis Kapetanakis ◽  
Helena C. Maltezou ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Influenza A ◽  
Neonatal Intensive Care ◽  
Pharmacokinetic Model ◽  
Population Pharmacokinetic ◽  
Oseltamivir Carboxylate ◽  
Influenza A H1n1 ◽  
Neonates And Infants

ABSTRACTDetailed oseltamivir pharmacokinetics have yet to be reported in neonates and infants; this group is at high risk of serious influenza-associated complications. Extrapolation of doses from older patients is complicated by rapid organ and drug-metabolizing enzyme maturation. A pharmacokinetic study has been conducted during an influenza A(H1N1) outbreak in a neonatal intensive care unit. Each included patient provided 4 samples for oseltamivir and 4 samples for its active metabolite oseltamivir carboxylate. A population pharmacokinetic model was developed with NONMEM. Allometric weight scaling and maturation functions were addeda priorito scale for size and age based on literature values. Nine neonates and infants were recruited. A physiologically parameterized pharmacokinetic model predicted typical day 1 area under the curve (AUC0-12) values of 1,966 and 2,484 μg · h/liter for neonates and infants of ≤37 weeks of postmenstrual age (PMA) and >37 weeks of PMA treated with 1 mg/kg of body weight and 2 mg/kg, respectively. The corresponding steady-state AUC0-12values were 3,670 and 4,559 μg · h/liter. Premature neonates treated with 1 mg/kg and term babies treated with 2 mg/kg should have average oseltamivir carboxylate concentrations in a range similar to that for adults treated with 75 mg, corresponding to >200-fold above the half-maximal inhibitory concentration (IC50) value for influenza A(H1N1) from the start of therapy.

Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit

2018 ◽  
Vol 48 ◽  
pp. 172-177 ◽  
Author(s):  
José Garnacho-Montero ◽  
Cristina León-Moya ◽  
Antonio Gutiérrez-Pizarraya ◽  
Angel Arenzana-Seisdedos ◽  
Loreto Vidaur ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Influenza A ◽  
Clinical Characteristics ◽  
H1n1 Virus ◽  
Related Risk ◽  
Influenza A H1n1 ◽  
Immunosuppressed Patients

Clinical course of community-acquired respiratory syncytial virus pneumonia in newborns hospitalized in neonatal intensive care unit

2013 ◽  
Vol 61 (3) ◽  
pp. 235-244 ◽  
Author(s):  
Banu AYDIN ◽  
Ayşegül ZENCİROĞLU ◽  
Dilek DİLLİ ◽  
Nurullah OKUMUŞ ◽  
M. Şah İPEK ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Respiratory Syncytial Virus ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Clinical Course ◽  
Virus Pneumonia ◽  
Syncytial Virus

An Outbreak of Influenza A in a Neonatal Intensive Care Unit

2000 ◽  
Vol 21 (7) ◽  
pp. 449-454 ◽  
Author(s):  
Robert J. Cunney ◽  
Anne Bialachowski ◽  
Diane Thornley ◽  
Fiona M. Smaill ◽  
Ross A. Pennie
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Cohort Study ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Influenza A ◽  
Neonatal Intensive Care ◽  
Twin Pregnancy ◽  
Multiple Logistic Regression Analysis

Objectives:Investigation of an outbreak of influenza A in a neonatal intensive care unit (NICU) with examination of risk factors for infection and outcomes.Design:Retrospective cohort study of infants admitted to the unit during the outbreak period. Prospective survey of NICU staff and mothers of infants in the cohort study.Setting:Level III nursery in a university-affiliated tertiary referral center.Results:Nineteen infants in the NICU were infected with influenza A. There were six symptomatic cases and one death who had evidence of virus-associated hemophagocytic syndrome at autopsy. Amantadine prophylaxis was offered to the NICU staff, and amantadine therapy was given to five of the six symptomatic infants. Mechanical ventilation, gestational age, birth weight, Clinical Risk Index for Babies score, and twin pregnancy were associated with acquisition of influenza A on univariate analysis. Mechanical ventilation (odds ratio [OR], 6.2;P=.02) and twin pregnancy (OR, 7.0;P=.04) remained as significant risk factors for infection on multiple logistic regression analysis. Only 15% of respondents to the NICU staff survey were vaccinated against influenza. There was no association between a history of an influenza-like illness during pregnancy and acquisition of influenza A by infants of mothers who responded to the maternal survey (OR, 0.91;P=1.0).Conclusions:Influenza A is an important pathogen in the neonatal population and is readily transmissible in the NICU setting.

Influenza A virus outbreak in a neonatal intensive care unit

1999 ◽  
Vol 18 (9) ◽  
pp. 811-815 ◽  
Author(s):  
FLOR M. MUNOZ ◽  
JUDITH R. CAMPBELL ◽  
ROBERT L. ATMAR ◽  
JOSEPH GARCIA-PRATS ◽  
BARBARA D. BAXTER ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Influenza A Virus ◽  
Influenza A ◽  
Neonatal Intensive Care

scholarly journals 1348 Influenza a H1N1 Virus Infection in a Pediactric Intensive Care Unit

2010 ◽  
Vol 68 ◽  
pp. 667-667
Author(s):  
P Neto ◽  
P V Silva ◽  
S Santos ◽  
C Pinto ◽  
A Dinis ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Virus Infection ◽  
Influenza A ◽  
H1n1 Virus ◽  
Influenza A H1n1 ◽  
H1n1 Virus Infection
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